1-amino-3-butylurea

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 3 g of 6,7-dimethoxy-4-chloro-quinazoline were stirred with 3.5 g of 4-n-butyl-semicarbazide in 100 ml of n-amyl alcohol for 2 hours at 100° C. Then, the precipitate which had formed was suction-filtered off, suspended while in hot ethanol and brought to pH 5 by the addition of 2N hydrochloric acid. The clear solution was filtered through charcoal, cooled, suction-filtered and dried in a circulating air drier. The hydrochloride of 4-n-butyl-4-(6,7-dimethoxyquinazol-4-yl)-semi-carbazide, which was obtained with a 70% yield, melted at 216°-217° C. The following compounds were obtained analogously. Then, the precipitate which had formed was suction-filtered off brought to pH 5 by the addition of 2N hydrochloric acid The clear solution was filtered through charcoal cooled suction-filtered dried in a circulating air drier

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 3 g of 6,7-dimethoxy-4-chloro-quinazoline were stirred with 3.5 g of 4-n-butyl-semicarbazide in 100 ml of n-amyl alcohol for 2 hours at 100° C. Then, the precipitate which had formed was suction-filtered off, suspended while in hot ethanol and brought to pH 5 by the addition of 2N hydrochloric acid. The clear solution was filtered through charcoal, cooled, suction-filtered and dried in a circulating air drier. The hydrochloride of 4-n-butyl-4-(6,7-dimethoxyquinazol-4-yl)-semi-carbazide, which was obtained with a 70% yield, melted at 216°-217° C. The following compounds were obtained analogously. Then, the precipitate which had formed was suction-filtered off brought to pH 5 by the addition of 2N hydrochloric acid The clear solution was filtered through charcoal cooled suction-filtered dried in a circulating air drier

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 3 g of 6,7-dimethoxy-4-chloro-quinazoline were stirred with 3.5 g of 4-n-butyl-semicarbazide in 100 ml of n-amyl alcohol for 2 hours at 100° C. Then, the precipitate which had formed was suction-filtered off, suspended while in hot ethanol and brought to pH 5 by the addition of 2N hydrochloric acid. The clear solution was filtered through charcoal, cooled, suction-filtered and dried in a circulating air drier. The hydrochloride of 4-n-butyl-4-(6,7-dimethoxyquinazol-4-yl)-semi-carbazide, which was obtained with a 70% yield, melted at 216°-217° C. The following compounds were obtained analogously. Then, the precipitate which had formed was suction-filtered off brought to pH 5 by the addition of 2N hydrochloric acid The clear solution was filtered through charcoal cooled suction-filtered dried in a circulating air drier