benzyl 2,2-dimethylpropanoate

反応条件: temp:0.00; pressure:0.00; stir:

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A sample of the product of step A (1.3 g, 3.0 mmol) was treated with 20% Pd(OH)2 on carbon (260 mg) and methanol (2 mL). The atmosphere in the reaction was exchanged for hydrogen by sparging the solution with a long needle for 3 minutes and the reaction was stirred under 1 atmosphere of hydrogen for 2 hours. The atmosphere was exchanged back to nitrogen by again sparging the solution with a long needle for 3 minutes. The reaction mixture was filtered through celite and the solvent was removed. The resulting oil was treated with Cbz-tBu-ala DCHA salt (1.8 g, 3.7 mmol), HATU (1.4 g, 3.8 mmol) and DMF (2 mL). The reaction was then treated with diisopropylethylamine (1.2 g, 9.2 mmol) and stirred overnight. The reaction was diluted with ethyl acetate and extracted with water twice and 1 M NaOH once. The organics were then dried over MgSO4 and the solvent was removed. The residue was purified over silica gel using a gradient of 0 to 100% ethyl acetate in hexane to afford 1.3 g (77%) of the title material as a solid; 1H NMR (CDCl3, 400 MHz) δ 0.92 (s, 9H), 1.39 (dd, 1H, J1=5.8, J2=14.4), 1.44 (s, 9H), 1.82 (dd, 1H, J1=3.7, J2=14.5), 2.51 (dd, 1H, J1=5.5, J2=16.2), 2.61 (dd, 1H, J1=4.7, J2=16.3), 2.92 (dd, 1H, J1=J2=8.2), 3.07 (dd, 1H, J1=7.4, J2=13.6), 3.17 (dd, 1H, J1=6.0, J2=13.8), 3.28-3.47 (m, 2H), 4.09-4.17 (m, 1H), 4.33-4.43 (m, 1H), 4.98-5.13 (m, 3H), 6.40 (dd, 1H, J1=4.0, J2=8.4), 6.69-6.84 (m, 3H), 7.26-7.37 (m, 5H); HPLC-MS calcd. for C31H42FN3O5 (M+H+) 556.3, found 556.5. by sparging the solution with a long needle for 3 minutes by again sparging the solution with a long needle for 3 minutes The reaction mixture was filtered through celite the solvent was removed stirred overnight extracted with water twice The organics were then dried over MgSO4 the solvent was removed The residue was purified over silica gel using a gradient of 0 to 100% ethyl acetate in hexane

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A sample of the product of step A (1.3 g, 3.0 mmol) was treated with 20% Pd(OH)2 on carbon (260 mg) and methanol (2 mL). The atmosphere in the reaction was exchanged for hydrogen by sparging the solution with a long needle for 3 minutes and the reaction was stirred under 1 atmosphere of hydrogen for 2 hours. The atmosphere was exchanged back to nitrogen by again sparging the solution with a long needle for 3 minutes. The reaction mixture was filtered through celite and the solvent was removed. The resulting oil was treated with Cbz-tBu-ala DCHA salt (1.8 g, 3.7 mmol), HATU (1.4 g, 3.8 mmol) and DMF (2 mL). The reaction was then treated with diisopropylethylamine (1.2 g, 9.2 mmol) and stirred overnight. The reaction was diluted with ethyl acetate and extracted with water twice and 1 M NaOH once. The organics were then dried over MgSO4 and the solvent was removed. The residue was purified over silica gel using a gradient of 0 to 100% ethyl acetate in hexane to afford 1.3 g (77%) of the title material as a solid; 1H NMR (CDCl3, 400 MHz) δ 0.92 (s, 9H), 1.39 (dd, 1H, J1=5.8, J2=14.4), 1.44 (s, 9H), 1.82 (dd, 1H, J1=3.7, J2=14.5), 2.51 (dd, 1H, J1=5.5, J2=16.2), 2.61 (dd, 1H, J1=4.7, J2=16.3), 2.92 (dd, 1H, J1=J2=8.2), 3.07 (dd, 1H, J1=7.4, J2=13.6), 3.17 (dd, 1H, J1=6.0, J2=13.8), 3.28-3.47 (m, 2H), 4.09-4.17 (m, 1H), 4.33-4.43 (m, 1H), 4.98-5.13 (m, 3H), 6.40 (dd, 1H, J1=4.0, J2=8.4), 6.69-6.84 (m, 3H), 7.26-7.37 (m, 5H); HPLC-MS calcd. for C31H42FN3O5 (M+H+) 556.3, found 556.5. by sparging the solution with a long needle for 3 minutes by again sparging the solution with a long needle for 3 minutes The reaction mixture was filtered through celite the solvent was removed stirred overnight extracted with water twice The organics were then dried over MgSO4 the solvent was removed The residue was purified over silica gel using a gradient of 0 to 100% ethyl acetate in hexane

反応条件: temp:0.00; pressure:0.00; stir:

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: To a suspended toluene (2 ml) solution of 2-chloro-1-methylpyridinium iodide (306 mg, 1.2 mmol) was added a mixture of benzyl alcohol (108 mg, 1.0 mmol), pivalic acid (102 mg, 1.0 mmol) and tri-n-butylamine (444 mg, 2.4 mmol) in toluene (2 ml), and the resulting mixture was refluxed for 3 hours. After evaporation of the solvent, the residue was separated by silica gel column chromatography, and benzyl pivalate was isolated in 62% yield. the resulting mixture was refluxed for 3 hours After evaporation of the solvent the residue was separated by silica gel column chromatography

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A sample of the product of step A (1.3 g, 3.0 mmol) was treated with 20% Pd(OH)2 on carbon (260 mg) and methanol (2 mL). The atmosphere in the reaction was exchanged for hydrogen by sparging the solution with a long needle for 3 minutes and the reaction was stirred under 1 atmosphere of hydrogen for 2 hours. The atmosphere was exchanged back to nitrogen by again sparging the solution with a long needle for 3 minutes. The reaction mixture was filtered through celite and the solvent was removed. The resulting oil was treated with Cbz-tBu-ala DCHA salt (1.8 g, 3.7 mmol), HATU (1.4 g, 3.8 mmol) and DMF (2 mL). The reaction was then treated with diisopropylethylamine (1.2 g, 9.2 mmol) and stirred overnight. The reaction was diluted with ethyl acetate and extracted with water twice and 1 M NaOH once. The organics were then dried over MgSO4 and the solvent was removed. The residue was purified over silica gel using a gradient of 0 to 100% ethyl acetate in hexane to afford 1.3 g (77%) of the title material as a solid; 1H NMR (CDCl3, 400 MHz) δ 0.92 (s, 9H), 1.39 (dd, 1H, J1=5.8, J2=14.4), 1.44 (s, 9H), 1.82 (dd, 1H, J1=3.7, J2=14.5), 2.51 (dd, 1H, J1=5.5, J2=16.2), 2.61 (dd, 1H, J1=4.7, J2=16.3), 2.92 (dd, 1H, J1=J2=8.2), 3.07 (dd, 1H, J1=7.4, J2=13.6), 3.17 (dd, 1H, J1=6.0, J2=13.8), 3.28-3.47 (m, 2H), 4.09-4.17 (m, 1H), 4.33-4.43 (m, 1H), 4.98-5.13 (m, 3H), 6.40 (dd, 1H, J1=4.0, J2=8.4), 6.69-6.84 (m, 3H), 7.26-7.37 (m, 5H); HPLC-MS calcd. for C31H42FN3O5 (M+H+) 556.3, found 556.5. by sparging the solution with a long needle for 3 minutes by again sparging the solution with a long needle for 3 minutes The reaction mixture was filtered through celite the solvent was removed stirred overnight extracted with water twice The organics were then dried over MgSO4 the solvent was removed The residue was purified over silica gel using a gradient of 0 to 100% ethyl acetate in hexane