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CC1=CC=CC=C1C(=O)C2=C(C=C(C=C2)N)Cl製品情報
(4-amino-2-chlorophenyl)-(2-methylphenyl)methanone (CAS 210967-34-3) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
想定用途
専門的研究・工業用途限定
データベース ID 10988565
安全上の注意
For professional research and industrial use only. Review the supplier safety data sheet before handling.
合成データ
9 反応 · 9 文献
反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-94614714bdb6405aad2ff0a623dc52cc反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-6de737abb82e49c9ac52f4c77c54ba03反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-94614714bdb6405aad2ff0a623dc52cc反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-6de737abb82e49c9ac52f4c77c54ba03反応条件: temp:100.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: 2-Chloro-3-nitro-pyridine (0.32 g, 2.0 mmol) and 4-amino-2-chloro-2′-methylbenzophenone (compound 2) (0.49 g, 2.0 mmol) was mixed thoroughly. The reaction mixture was warmed at 100° C. for 0.5 h and then at 160° C. for 0.5 h. The reaction mixture was cooled to room temperature, and dissolved in saturated aqueous NaHCO3 (10 mL) and EtOAc (30 mL). The phases were separated, and the organic phase was washed with saturated aqueous NaHCO3 (10 mL), dried (MgSO4), filtered and concentrated in vacuo. The reaction mixture was cooled to room temperature The phases were separated the organic phase was washed with saturated aqueous NaHCO3 (10 mL) dried (MgSO4) filtered concentrated in vacuo
ソース ID: ord-e1ea0df6416d45fb92efe078ad33becf反応条件: temp:100.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: 2-Chloro-3-nitro-pyridine (0.32 g, 2.0 mmol) and 4-amino-2-chloro-2′-methylbenzophenone (compound 2) (0.49 g, 2.0 mmol) was mixed thoroughly. The reaction mixture was warmed at 100° C. for 0.5 h and then at 160° C. for 0.5 h. The reaction mixture was cooled to room temperature, and dissolved in saturated aqueous NaHCO3 (10 mL) and EtOAc (30 mL). The phases were separated, and the organic phase was washed with saturated aqueous NaHCO3 (10 mL), dried (MgSO4), filtered and concentrated in vacuo. The reaction mixture was cooled to room temperature The phases were separated the organic phase was washed with saturated aqueous NaHCO3 (10 mL) dried (MgSO4) filtered concentrated in vacuo
ソース ID: ord-e1ea0df6416d45fb92efe078ad33becf反応条件: temp:100.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: 2-Chloro-3-nitro-pyridine (0.32 g, 2.0 mmol) and 4-amino-2-chloro-2′-methylbenzophenone (compound 2) (0.49 g, 2.0 mmol) was mixed thoroughly. The reaction mixture was warmed at 100° C. for 0.5 h and then at 160° C. for 0.5 h. The reaction mixture was cooled to room temperature, and dissolved in saturated aqueous NaHCO3 (10 mL) and EtOAc (30 mL). The phases were separated, and the organic phase was washed with saturated aqueous NaHCO3 (10 mL), dried (MgSO4), filtered and concentrated in vacuo. The reaction mixture was cooled to room temperature The phases were separated the organic phase was washed with saturated aqueous NaHCO3 (10 mL) dried (MgSO4) filtered concentrated in vacuo
ソース ID: ord-e1ea0df6416d45fb92efe078ad33becf反応条件: temp:120.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: A mixture of (4-amino-2-chlorophenyl)(2-methylphenyl)methanone (61 mg. 0.25 mmol) (disclosed in WO 01/42189 A1), compound 436 (89 mg, 0.30 mmol), BINAP (5 mg), Pd2(dba)3 (5 mg) and Cs2CO3 (114 mg, 0.35 mmol) in 1,4-dioxane (5 ml) was heated to 120° C. under stirring for 3 days. The reaction mixture was filtered. The obtained solution was concentrated in vacuo. The residue was purified by chromatography (petroleum ether/ethyl acetate 1:1) to provide the desired product, which was not pure. The impure product was further purified by preparative TLC (petroleum ether/ethyl acetate 2:1) to give the pure title compound as brownish oil. The reaction mixture was filtered The obtained solution was concentrated in vacuo The residue was purified by chromatography (petroleum ether/ethyl acetate 1:1)
ソース ID: ord-8c01a3d927a24472a597fc8e4b75397c反応条件: temp:100.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: Compound 420 (3.39 g, 10.3 mmol) was dissolved in 15 mL dry 1,4-dioxane in a schlenk tube under an argon atmosphere. (4-Amino-2-chlorophenyl)(2-methylphenyl)methanone (disclosed in WO 01/42189) was added and dissolved in the solvent. Rac-BINAP (0.26 g, 0.42 mmol), Pd2(dba)3 (0.19 g, 0.20 mmol) and Cs2CO3 (4.7 g, 14.4 mmol) were added, and the reaction mixture was stirred under an argon atmosphere at 100° C. for 18 h. The reaction mixture was diluted with H2O and EtOAc, and the water phase was extracted twice with EtOAc. The combined organic phases were washed with brine, dried (MgSO4) and evaporated in vacuo. The crude product was purified by flash chromatography using DCM/acetone 100:1 as the eluent to afford the title compound as an oil. dissolved in the solvent the water phase was extracted twice with EtOAc The combined organic phases were washed with brine dried (MgSO4) evaporated in vacuo The crude product was purified by flash chromatography
ソース ID: ord-e5ecc4e888d04b2e8fbe7ba37f5302f0PubChem References
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