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C1=C(C(=CC(=C1S(=O)(=O)N)F)Br)F製品情報
4-bromo-2,5-difluorobenzenesulfonamide (CAS 214209-98-0) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
想定用途
専門的研究・工業用途限定
データベース ID 2773293
安全上の注意
For professional research and industrial use only. Review the supplier safety data sheet before handling.
合成データ
9 反応 · 9 文献
反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-8645ab2a846a4bd2a88d60f89029b9b9反応条件: temp:80.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: Prepared according to the method described in Example 12) from (1S,2R)-4-(2-hydroxy-1-methyl-4-pyridin-3-ylbutoxy)benzeneboronic acid (0.2 g, Example 33), 4-bromo-2,5-difluorobenzenesulfonamide (0.19 g, Example 37a)), ethanol (3 ml), 2M aqueous sodium carbonate (0.7 ml) and tetrakis(triphenylphosphine)palladium (0) (0.03 g) with heating at 80° C. for 3 hours. After work-up, the residue was purified by normal-phase HPLC eluting with a gradient of 0-25% ethanol in dichloromethane to give the title compound as a foam (0.11 g). Prepared After work-up, the residue was purified by normal-phase HPLC eluting with a gradient of 0-25% ethanol in dichloromethane
ソース ID: ord-40aa2691177f42fb8a7f311de55bd7c5反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: Ammonium hydroxide (5 ml) was added to a solution of 2,5-difluoro-4-bromophenylsulfonyl chloride (4.3 g) in tetrahydrofuran (20 ml) at room temperature (CARE:exotherm) and stirred for 10 min. The reaction mixture was poured into water and extracted with ethyl acetate. The ethyl acetate was dried over anhydrous magnesium sulfate and filtered. The filtrate was evaporated and the residue triturated with 20% diethyl ether in isohexane to give the sub-title compound as a solid (4.3 g). extracted with ethyl acetate The ethyl acetate was dried over anhydrous magnesium sulfate filtered The filtrate was evaporated the residue triturated with 20% diethyl ether in isohexane
ソース ID: ord-80781d6e4daf441a96141ea53578b925反応条件: temp:80.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: Prepared according to the method described in Example 12) from (1S,2R)-4-(2-hydroxy-1-methyl-4-pyridin-3-ylbutoxy)benzeneboronic acid (0.2 g, Example 33), 4-bromo-2,5-difluorobenzenesulfonamide (0.19 g, Example 37a)), ethanol (3 ml), 2M aqueous sodium carbonate (0.7 ml) and tetrakis(triphenylphosphine)palladium (0) (0.03 g) with heating at 80° C. for 3 hours. After work-up, the residue was purified by normal-phase HPLC eluting with a gradient of 0-25% ethanol in dichloromethane to give the title compound as a foam (0.11 g). Prepared After work-up, the residue was purified by normal-phase HPLC eluting with a gradient of 0-25% ethanol in dichloromethane
ソース ID: ord-40aa2691177f42fb8a7f311de55bd7c5反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: Ammonium hydroxide (5 ml) was added to a solution of 2,5-difluoro-4-bromophenylsulfonyl chloride (4.3 g) in tetrahydrofuran (20 ml) at room temperature (CARE:exotherm) and stirred for 10 min. The reaction mixture was poured into water and extracted with ethyl acetate. The ethyl acetate was dried over anhydrous magnesium sulfate and filtered. The filtrate was evaporated and the residue triturated with 20% diethyl ether in isohexane to give the sub-title compound as a solid (4.3 g). extracted with ethyl acetate The ethyl acetate was dried over anhydrous magnesium sulfate filtered The filtrate was evaporated the residue triturated with 20% diethyl ether in isohexane
ソース ID: ord-80781d6e4daf441a96141ea53578b925反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-8645ab2a846a4bd2a88d60f89029b9b9反応条件: temp:80.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: Prepared according to the method described in Example 12) from (1S,2R)-4-(2-hydroxy-1-methyl-4-pyridin-3-ylbutoxy)benzeneboronic acid (0.2 g, Example 33), 4-bromo-2,5-difluorobenzenesulfonamide (0.19 g, Example 37a)), ethanol (3 ml), 2M aqueous sodium carbonate (0.7 ml) and tetrakis(triphenylphosphine)palladium (0) (0.03 g) with heating at 80° C. for 3 hours. After work-up, the residue was purified by normal-phase HPLC eluting with a gradient of 0-25% ethanol in dichloromethane to give the title compound as a foam (0.11 g). Prepared After work-up, the residue was purified by normal-phase HPLC eluting with a gradient of 0-25% ethanol in dichloromethane
ソース ID: ord-40aa2691177f42fb8a7f311de55bd7c5反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: Ammonium hydroxide (5 ml) was added to a solution of 2,5-difluoro-4-bromophenylsulfonyl chloride (4.3 g) in tetrahydrofuran (20 ml) at room temperature (CARE:exotherm) and stirred for 10 min. The reaction mixture was poured into water and extracted with ethyl acetate. The ethyl acetate was dried over anhydrous magnesium sulfate and filtered. The filtrate was evaporated and the residue triturated with 20% diethyl ether in isohexane to give the sub-title compound as a solid (4.3 g). extracted with ethyl acetate The ethyl acetate was dried over anhydrous magnesium sulfate filtered The filtrate was evaporated the residue triturated with 20% diethyl ether in isohexane
ソース ID: ord-80781d6e4daf441a96141ea53578b925反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-8645ab2a846a4bd2a88d60f89029b9b9PubChem References
化合物の公開データベース記録に掲載された情報源です。
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