methyl 3-chloro-2,2-dimethylpropanoate

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 219 g of chloropivaloyl chloride was added drop-by-drop to a chilled (0°-5° C.), stirred solution of 141.4 g of triethylamine in 320 g of anhydrous methanol. The resulting mixture was warmed to room temperature in one hour, and most of the methanol was evaporated under reduced pressure. The residue was drowned in water and extracted with ether. The extract was dried (MgSO4) and the solvent was evaporated. The residue was distilled to give methyl 3-chloro-2,2-dimethylpropionate (2A), b.p.: 40°-50° C. (14 Torr.). a chilled (0°-5° C.) most of the methanol was evaporated under reduced pressure extracted with ether The extract was dried (MgSO4) the solvent was evaporated The residue was distilled

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 219 g of chloropivaloyl chloride was added drop-by-drop to a chilled (0°-5° C.), stirred solution of 141.4 g of triethylamine in 320 g of anhydrous methanol. The resulting mixture was warmed to room temperature in one hour, and most of the methanol was evaporated under reduced pressure. The residue was drowned in water and extracted with ether. The extract was dried (MgSO4) and the solvent was evaporated. The residue was distilled to give methyl 3-chloro-2,2-dimethylpropionate (2A), b.p.: 40°-50° C. (14 Torr.). a chilled (0°-5° C.) most of the methanol was evaporated under reduced pressure extracted with ether The extract was dried (MgSO4) the solvent was evaporated The residue was distilled

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 219 g of chloropivaloyl chloride was added drop-by-drop to a chilled (0°-5° C.), stirred solution of 141.4 g of triethylamine in 320 g of anhydrous methanol. The resulting mixture was warmed to room temperature in one hour, and most of the methanol was evaporated under reduced pressure. The residue was drowned in water and extracted with ether. The extract was dried (MgSO4) and the solvent was evaporated. The residue was distilled to give methyl 3-chloro-2,2-dimethylpropionate (2A), b.p.: 40°-50° C. (14 Torr.). a chilled (0°-5° C.) most of the methanol was evaporated under reduced pressure extracted with ether The extract was dried (MgSO4) the solvent was evaporated The residue was distilled

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 219 g of chloropivaloyl chloride was added drop-by-drop to a chilled (0°-5° C.), stirred solution of 141.4 g of triethylamine in 320 g of anhydrous methanol. The resulting mixture was warmed to room temperature in one hour, and most of the methanol was evaporated under reduced pressure. The residue was mixed with water and extracted with ether. The extract was dried (MgSO4), and the solvent was evaporated. The residue was distilled to give methyl 3-chloro-2,2-dimethylpropionate (3A), b.p.: 40°-50° C. (14 Torr.). a chilled (0°-5° C.) most of the methanol was evaporated under reduced pressure The residue was mixed with water extracted with ether The extract was dried (MgSO4) the solvent was evaporated The residue was distilled