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COC(=O)C1=CC(=CC(=C1)I)N製品情報
methyl 3-amino-5-iodobenzoate (CAS 217314-45-9) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
想定用途
専門的研究・工業用途限定
データベース ID 11000339
安全上の注意
For professional research and industrial use only. Review the supplier safety data sheet before handling.
合成データ
9 反応 · 9 文献
反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-ffaf44600227481584c50f63abdc3465反応条件: temp:100.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: To a flask containing methyl 3-amino-5-iodobenzoate (500 mg, 1.81 mmol) was added a solution of 2-chloro-4-(trifluoromethyl)pyrimidine (379 mg, 2.08 mmol) in dioxane (5.6 mL). Methanesulfonic acid (199 mg, 2.08 mmol) was added and the reaction was heated at 100° C. overnight. The reaction was cooled, diluted with ethyl acetate, washed with water, dried over magnesium sulfate, filtered and concentrated. Flash chromatography was used for purification to yield methyl 3-iodo-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}benzoate (538 mg, 1.27 mmol, 71% yield). MS ESI: [M+H]+ m/z 424.0. The reaction was cooled washed with water dried over magnesium sulfate filtered concentrated Flash chromatography was used for purification
ソース ID: ord-18d3fbf6a18a45d099a0e9c5545dd968反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-ffaf44600227481584c50f63abdc3465反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-ffaf44600227481584c50f63abdc3465反応条件: temp:100.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: To a flask containing methyl 3-amino-5-iodobenzoate (500 mg, 1.81 mmol) was added a solution of 2-chloro-4-(trifluoromethyl)pyrimidine (379 mg, 2.08 mmol) in dioxane (5.6 mL). Methanesulfonic acid (199 mg, 2.08 mmol) was added and the reaction was heated at 100° C. overnight. The reaction was cooled, diluted with ethyl acetate, washed with water, dried over magnesium sulfate, filtered and concentrated. Flash chromatography was used for purification to yield methyl 3-iodo-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}benzoate (538 mg, 1.27 mmol, 71% yield). MS ESI: [M+H]+ m/z 424.0. The reaction was cooled washed with water dried over magnesium sulfate filtered concentrated Flash chromatography was used for purification
ソース ID: ord-f4b85e409a644cbea607150d732c1996反応条件: temp:100.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: To a flask containing methyl 3-amino-5-iodobenzoate (500 mg, 1.81 mmol) was added a solution of 2-chloro-4-(trifluoromethyl)pyrimidine (379 mg, 2.08 mmol) in dioxane (5.6 mL). Methanesulfonic acid (199 mg, 2.08 mmol) was added and the reaction was heated at 100° C. overnight. The reaction was cooled, diluted with ethyl acetate, washed with water, dried over magnesium sulfate, filtered and concentrated. Flash chromatography was used for purification to yield methyl 3-iodo-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}benzoate (538 mg, 1.27 mmol, 71% yield). MS ESI: [M+H]+ m/z 424.0. The reaction was cooled washed with water dried over magnesium sulfate filtered concentrated Flash chromatography was used for purification
ソース ID: ord-18d3fbf6a18a45d099a0e9c5545dd968反応条件: temp:100.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: To a flask containing methyl 3-amino-5-iodobenzoate (500 mg, 1.81 mmol) was added a solution of 2-chloro-4-(trifluoromethyl)pyrimidine (379 mg, 2.08 mmol) in dioxane (5.6 mL). Methanesulfonic acid (199 mg, 2.08 mmol) was added and the reaction was heated at 100° C. overnight. The reaction was cooled, diluted with ethyl acetate, washed with water, dried over magnesium sulfate, filtered and concentrated. Flash chromatography was used for purification to yield methyl 3-iodo-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}benzoate (538 mg, 1.27 mmol, 71% yield). MS ESI: [M+H]+ m/z 424.0. The reaction was cooled washed with water dried over magnesium sulfate filtered concentrated Flash chromatography was used for purification
ソース ID: ord-18d3fbf6a18a45d099a0e9c5545dd968反応条件: temp:100.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: To a flask containing methyl 3-amino-5-iodobenzoate (500 mg, 1.81 mmol) was added a solution of 2-chloro-4-(trifluoromethyl)pyrimidine (379 mg, 2.08 mmol) in dioxane (5.6 mL). Methanesulfonic acid (199 mg, 2.08 mmol) was added and the reaction was heated at 100° C. overnight. The reaction was cooled, diluted with ethyl acetate, washed with water, dried over magnesium sulfate, filtered and concentrated. Flash chromatography was used for purification to yield methyl 3-iodo-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}benzoate (538 mg, 1.27 mmol, 71% yield). MS ESI: [M+H]+ m/z 424.0. The reaction was cooled washed with water dried over magnesium sulfate filtered concentrated Flash chromatography was used for purification
ソース ID: ord-f4b85e409a644cbea607150d732c1996反応条件: temp:100.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: To a flask containing methyl 3-amino-5-iodobenzoate (500 mg, 1.81 mmol) was added a solution of 2-chloro-4-(trifluoromethyl)pyrimidine (379 mg, 2.08 mmol) in dioxane (5.6 mL). Methanesulfonic acid (199 mg, 2.08 mmol) was added and the reaction was heated at 100° C. overnight. The reaction was cooled, diluted with ethyl acetate, washed with water, dried over magnesium sulfate, filtered and concentrated. Flash chromatography was used for purification to yield methyl 3-iodo-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}benzoate (538 mg, 1.27 mmol, 71% yield). MS ESI: [M+H]+ m/z 424.0. The reaction was cooled washed with water dried over magnesium sulfate filtered concentrated Flash chromatography was used for purification
ソース ID: ord-18d3fbf6a18a45d099a0e9c5545dd968PubChem References
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