(3R)-3-cyclohexyl-4-methoxy-4-oxobutanoic acid

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: To a suspension of (3R)-3-cyclohexyl-4-methoxy-4-oxobutanoic acid (0.21 g), 4-chloroaniline (0.13 g) and HOBt (0.23 g) in acetonitrile (10 ml) were added WSC (0.29 g) and N-methylmorpholine (0.10 g), and mixed at room temperature for 15 hours. The reaction mixture was concentrated under reduced pressure, and the residue was dissolved in ethyl acetate. The ethyl acetate solution was washed sequentially with an aqueous sodium hydrogen carbonate solution, water, a 5% aqueous citric acid solution and saturated brine, and dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure to obtain the title compound as a pale brown solid (0.30 g, 93%). mixed at room temperature for 15 hours The reaction mixture was concentrated under reduced pressure the residue was dissolved in ethyl acetate The ethyl acetate solution was washed sequentially with an aqueous sodium hydrogen carbonate solution, water a 5% aqueous citric acid solution and saturated brine, and dried over anhydrous sodium sulfate The solvent was distilled off under reduced pressure