pentadecan-2-one

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Pentadecanone (200 g) was added a 3-litre three-necked flask under nitrogen, to which diethyl ether (1000 ml) was slowly added from a dropping funnel. Sodium borohydride (63.54 g) was then slowly added and the mixture stirred for two days at room temperature under nitrogen. Toluene was added to the reaction vessel and the contents transferred to a separating funnel. The organic layer was washed with water and the aqueous layer was collected. The aqueous layer was washed with toluene, which was combined with the previous organic layer. The product was dried with magnesium sulphate and filtered under vacuum. The solvent was then stripped on a rotary evaporator at 100° C. to yield the title compound. the contents transferred to a separating funnel The organic layer was washed with water the aqueous layer was collected The aqueous layer was washed with toluene, which The product was dried with magnesium sulphate filtered under vacuum The solvent was then stripped on a rotary evaporator at 100° C.

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: The title compound was prepared from 2-pentadecanone (0.54 g, 0.0023 mol), 2,4,6-trimethoxyphenyl isocyanate (prepared from 2,4,6-trimethoxyaniline hydrochloride and phosgene (2.5 eq)) and lithium diisopropylamide (0.0023 mol) using the procedure described in Example 1.

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: The title compound was prepared from 2-pentadecanone (3.0 g, 0.013 mol), 2,6-diisopropylphenyl isocyanate (2.64 g, 0.013 mol), and lithium diisopropylamide (0.013 mol) using the procedure described in Example 1. Purification by flash chromatography (silica gel, 15% EtOAc/hexane) yielded 1.92 g (0.004, 34%) of the desired product. Purification by flash chromatography (silica gel, 15% EtOAc/hexane)