N'-propylpropane-1,3-diamine

反応条件: temp:0.00; pressure:0.00; stir:

反応条件: temp:0.00; pressure:0.00; stir:

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: To a stirred solution of 1,5-diazaoctane (16) (0.58 g, 0.005 mol) in dry benzene (20 mL) was added dropwise pyridine-2-carboxaldehyde (0.535 g, 0.005 mol) in dry benzene (10 mL). The resulting solution was refluxed for 2 hr using a Dean-Stark trap to remove water. Finally, the solvent was removed completely by distillation to give compound (17) in quantitative yield (1.0 g). The resulting solution was refluxed for 2 hr to remove water Finally, the solvent was removed completely by distillation

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 22.6 Parts of o-benzoyl-benzoic acid and 11.6 parts of N-propyl-1,3-propanediamine are haeted within 11/2 hours with 50 parts by volume of o-dichlorobenzene until the boiling point of the latter is attained. Almost the theoretical amount of reaction water is azeotropically distilled off. The clear solution is evaporated to dryness in vacuo, the oily residue is dissolved in ethyl acetate and crystallised by the dropwise addition of pentane. In this way, 1-propyl-10b-phenyl-1,3,4,10b-tetrahydro-pyrimido[2,1-a]isoindol-6(2H)-one is obtained of the formula ##STR19## M.P. 135°-137°. 1-Ethyl-10b-phenyl-1,3,4,10b-tetrahydro-pyrimido[2,1-a]isoindol -6(2H)-one is obtained in the same manner from o-benzoyl-benzoic acid and N-ethyl-1,3-propanediamine. M.P. 131°-133°. 2 hours is azeotropically distilled off The clear solution is evaporated to dryness in vacuo the oily residue is dissolved in ethyl acetate crystallised by the dropwise addition of pentane