tert-butyl 3-(hydroxymethyl)-3,4-dihydro-1H-isoquinoline-2-carboxylate

反応条件: temp:0.00; pressure:0.00; stir:

反応条件: temp:0.00; pressure:0.00; stir:

反応条件: temp:0.00; pressure:0.00; stir:

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: To N-tert-Butyloxycarbonyl-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinoline (9 g) dissolved in tetrahydrofuran (200 mL) at 0° C. was added sodium hydride (60% in mineral oil 1.64 g). The mixture wa stirred for 50 minutes then, carbon disulfide (2.5 mL) was added and stirred for an additional 1 hour. Then methyl iodide (2.55 mL) was added and after two hours ammonium hydroxide (28% solution, 10.4 mL) was added. After overnight stirring, brine was added, the mixture was extracted with methylene chloride and the extract concentrated to yield the product as a solid (5.6 g). stirred for an additional 1 hour was added After overnight stirring the mixture was extracted with methylene chloride the extract concentrated

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: To N-tert-Butyloxycarbonyl-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinoline (9 g) dissolved in tetrahydrofuran (200 mL) at 0° C. was added sodium hydride (60% in mineral oil 1.64 g). The mixture wa stirred for 50 minutes then, carbon disulfide (2.5 mL) was added and stirred for an additional 1 hour. Then methyl iodide (2.55 mL) was added and after two hours ammonium hydroxide (28% solution, 10.4 mL) was added. After overnight stirring, brine was added, the mixture was extracted with methylene chloride and the extract concentrated to yield the product as a solid (5.6 g). stirred for an additional 1 hour was added After overnight stirring the mixture was extracted with methylene chloride the extract concentrated