2-bromo-N-(2,4-dimethylphenyl)acetamide

反応条件: temp:0.00; pressure:0.00; stir:

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 117 g of triethylamine and 140 g of 2,4-dimethylaniline are dissolved in 2 l of methylene chloride, and a solution of 233 g of alpha-bromoacetyl bromide in 400 ml of methylene chloride is added with ice-cooling, at at most 15° C., within 30 min. After a reaction time of 30 min, the precipitate is filtered off with suction, the residue is dissolved in 3 l of methylene chloride and combined with the filtrate and washed twice with 2 l of water and 2 l of sat. sodium chloride solution. The mixture is dried over sodium sulphate, filtered off with suction and concentrated, and the residue is recrystallized from ethanol. This gives 193 g of the title compound. cooling, at at most 15° C., within 30 min After a reaction time of 30 min, the precipitate is filtered off with suction the residue is dissolved in 3 l of methylene chloride washed twice with 2 l of water and 2 l of sat. sodium chloride solution The mixture is dried over sodium sulphate filtered off with suction concentrated the residue is recrystallized from ethanol

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 117 g of triethylamine and 140 g of 2,4-dimethylaniline are dissolved in 2 l of methylene chloride, and a solution of 233 g of alpha-bromoacetyl bromide in 400 ml of methylene chloride is added with ice-cooling, at at most 15° C., within 30 min. After a reaction time of 30 min, the precipitate is filtered off with suction, the residue is dissolved in 3 l of methylene chloride and combined with the filtrate and washed twice with 2 l of water and 2 l of sat. sodium chloride solution. The mixture is dried over sodium sulphate, filtered off with suction and concentrated, and the residue is recrystallized from ethanol. This gives 193 g of the title compound. cooling, at at most 15° C., within 30 min After a reaction time of 30 min, the precipitate is filtered off with suction the residue is dissolved in 3 l of methylene chloride washed twice with 2 l of water and 2 l of sat. sodium chloride solution The mixture is dried over sodium sulphate filtered off with suction concentrated the residue is recrystallized from ethanol

反応条件: temp:0.00; pressure:0.00; stir:

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 117 g of triethylamine and 140 g of 2,4-dimethylaniline are dissolved in 21 of methylene chloride, and a solution of 233 g of alpha-bromoacetyl bromide in 400 ml of methylene chloride is added with ice-cooling, at at most 15° C., within 30 min. After a reaction time of 30 min, the precipitate is filtered off with suction, the residue is dissolved in 3 l of methylene chloride and combined with the filtrate and washed twice with 2 l of water and 2 l of sat. sodium chloride solution. The mixture is dried over sodium sulphate, filtered off with suction and concentrated, and the residue is recrystallized from ethanol. This gives 193 g of the title compound. cooling, at at most 15° C., within 30 min After a reaction time of 30 min, the precipitate is filtered off with suction the residue is dissolved in 3 l of methylene chloride washed twice with 2 l of water and 2 l of sat. sodium chloride solution The mixture is dried over sodium sulphate filtered off with suction concentrated the residue is recrystallized from ethanol

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 117 g of triethylamine and 140 g of 2,4-dimethylaniline are dissolved in 2 l of methylene chloride, and a solution of 233 g of alpha-bromoacetyl bromide in 400 ml of methylene chloride is added with ice-cooling, at at most 15° C., within 30 min. After a reaction time of 30 min, the precipitate is filtered off with suction, the residue is dissolved in 3 l of methylene chloride and combined with the filtrate and washed twice with 2 l of water and 2 l of sat. sodium chloride solution. The mixture is dried over sodium sulphate, filtered off with suction and concentrated, and the residue is recrystallized from ethanol. This gives 193 g of the title compound. cooling, at at most 15° C., within 30 min After a reaction time of 30 min, the precipitate is filtered off with suction the residue is dissolved in 3 l of methylene chloride washed twice with 2 l of water and 2 l of sat. sodium chloride solution The mixture is dried over sodium sulphate filtered off with suction concentrated the residue is recrystallized from ethanol