N-(4-chlorophenyl)formamide

反応条件: temp:0.00; pressure:0.00; stir:

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Was prepared according to Example 3 from N-(4-chloro-phenyl)-formamide and 2,6-dichloro-7-methyl-7H-purine. Was prepared

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Was prepared according to Example 3 from N-(4-chloro-phenyl)-formamide and 2,6-dichloro-7-methyl-7H-purine. Was prepared

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Was prepared according to Example 3 from N-(4-chloro-phenyl)-formamide and 2,6-dichloro-9-(2-ethoxy-ethyl)-9H-purine. Was prepared

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Was prepared according to Example 3 from N-(4-chloro-phenyl)-formamide and 2,6-dichloro-9-isobutyl-9H-purine. Was prepared

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Was prepared according to Example 3 from N-(4-chloro-phenyl)-formamide and 2,6-dichloro-9-isobutyl-9H-purine. Was prepared

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Was prepared according to Example 3 from N-(4-chloro-phenyl)-formamide and 2,6-dichloro-9-ethyl-9H-purine. Was prepared

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Was prepared according to Example 3 from N-(4-chloro-phenyl)-formamide and 2,6-dichloro-9-ethyl-9H-purine. Was prepared

反応条件: temp:80.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: N-(4-Chloro-phenyl)-formamide (766 mg, 4.93 mmol) was dissolved in N,N-dimethylformamide (10 mL). Sodium hydride (60% in mineral oil, 240 mg, 5.91 mmol) was added and the mixture was stirred for 30 min. 2,6-Dichloro-9-methyl-9H-purine (1.0 g, 4.93 mmol) was added and the reaction mixture was heated at 80° C. for 2 hours, cooled to room temperature and poured into water. The resulting precipitate was collected by filtration, washed with water and dried to give (2-chloro-9-methyl-9H-purin-6-yl)-(4-chloro-phenyl)-amine (1.2 g, 4.08 mmol, 83%). cooled to room temperature The resulting precipitate was collected by filtration washed with water dried

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 4-Chloroaniline (15 g, 117 mmol) and formic acid (25 mL, 663 mmol) were heated to reflux for 2 hours. The mixture was concentrated in vacuo. Saturated aqueous sodium hydrogen carbonate was added and the aqueous phase was extracted twice with ethyl acetate. The combined organic phases were dried over magnesium sulphate, filtered and concentrated in vacuo to give N-(4-chloro-phenyl)-formamide (17.6 g, 97%) as a grey crystalline compound. to reflux for 2 hours The mixture was concentrated in vacuo Saturated aqueous sodium hydrogen carbonate was added the aqueous phase was extracted twice with ethyl acetate The combined organic phases were dried over magnesium sulphate filtered concentrated in vacuo

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 4-Chloroaniline (15 g, 117 mmol) and formic acid (25 mL, 663 mmol) were heated to reflux for 2 hours. The mixture was concentrated in vacuo. Saturated aqueous sodium hydrogen carbonate was added and the aqueous phase was extracted twice with ethyl acetate. The combined organic phases were dried over magnesium sulphate, filtered and concentrated in vacuo to give N-(4-chloro-phenyl)-formamide (17.6 g, 97%) as a grey crystalline compound. to reflux for 2 hours The mixture was concentrated in vacuo Saturated aqueous sodium hydrogen carbonate was added the aqueous phase was extracted twice with ethyl acetate The combined organic phases were dried over magnesium sulphate filtered concentrated in vacuo

反応条件: temp:0.00; pressure:0.00; stir: