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FC(C1=CC=CC=C1C(C)N)(F)F製品情報
1-(2-Trifluoromethylphenyl)ethylamine (CAS 273384-78-4) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
想定用途
専門的研究・工業用途限定
データベース ID 2782450
安全上の注意
For professional research and industrial use only. Review the supplier safety data sheet before handling.
合成データ
12 反応 · 12 文献
反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-c5677cf3287e4d37a109b1d9dccdefb5反応条件: temp:25.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: Sodium borohydride (1.17 g) is added slowly to a flask containing zirconium tetrachloride (1.8 g) in tetrahydrofuran (27 mL). A solution of 1-(2-trifluoromethyl-phenyl)-ethanone O-methyl-oxime (1.34 g) in tetrahydrofuran (7.7 mL) is added and the resulting solution is stirred at 25° C. for 12 hours. The reaction mixture is then cooled to 0° C. and water (16 mL) is slowly added. Excess ammonium hydroxide is added and the solution is extracted twice with ethyl acetate. The organic portion is washed twice with 1N hydrochloric acid. The aqueous (acid) layer is basified with sodium hydroxide and extracted twice with ethyl acetate. The organic layer is then washed with saturated aqueous sodium chloride and dried over anhydrous magnesium sulfate. The solvent is removed under reduced pressure to provide the desired product as a yellow oil (0.20 g). The reaction mixture is then cooled to 0° C. the solution is extracted twice with ethyl acetate The organic portion is washed twice with 1N hydrochloric acid extracted twice with ethyl acetate The organic layer is then washed with saturated aqueous sodium chloride dried over anhydrous magnesium sulfate The solvent is removed under reduced pressure
ソース ID: ord-4b3bf6f75ef34627bf30faadf092c1bc反応条件: temp:25.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: Sodium borohydride (1.17 g) is added slowly to a flask containing zirconium tetrachloride (1.8 g) in tetrahydrofuran (27 mL). A solution of 1-(2-trifluoromethyl-phenyl)-ethanone O-methyl-oxime (1.34 g) in tetrahydrofuran (7.7 mL) is added and the resulting solution is stirred at 25° C. for 12 hours. The reaction mixture is then cooled to 0° C. and water (16 mL) is slowly added. Excess ammonium hydroxide is added and the solution is extracted twice with ethyl acetate. The organic portion is washed twice with 1N hydrochloric acid. The aqueous (acid) layer is basified with sodium hydroxide and extracted twice with ethyl acetate. The organic layer is then washed with saturated aqueous sodium chloride and dried over anhydrous magnesium sulfate. The solvent is removed under reduced pressure to provide the desired product as a yellow oil (0.20 g). The reaction mixture is then cooled to 0° C. the solution is extracted twice with ethyl acetate The organic portion is washed twice with 1N hydrochloric acid extracted twice with ethyl acetate The organic layer is then washed with saturated aqueous sodium chloride dried over anhydrous magnesium sulfate The solvent is removed under reduced pressure
ソース ID: ord-3e697578ba174cbc989e02fcea4015bc反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-c5677cf3287e4d37a109b1d9dccdefb5反応条件: temp:25.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: Sodium borohydride (1.17 g) is added slowly to a flask containing zirconium tetrachloride (1.8 g) in tetrahydrofuran (27 mL). A solution of 1-(2-trifluoromethyl-phenyl)-ethanone O-methyl-oxime (1.34 g) in tetrahydrofuran (7.7 mL) is added and the resulting solution is stirred at 25° C. for 12 hours. The reaction mixture is then cooled to 0° C. and water (16 mL) is slowly added. Excess ammonium hydroxide is added and the solution is extracted twice with ethyl acetate. The organic portion is washed twice with 1N hydrochloric acid. The aqueous (acid) layer is basified with sodium hydroxide and extracted twice with ethyl acetate. The organic layer is then washed with saturated aqueous sodium chloride and dried over anhydrous magnesium sulfate. The solvent is removed under reduced pressure to provide the desired product as a yellow oil (0.20 g). The reaction mixture is then cooled to 0° C. the solution is extracted twice with ethyl acetate The organic portion is washed twice with 1N hydrochloric acid extracted twice with ethyl acetate The organic layer is then washed with saturated aqueous sodium chloride dried over anhydrous magnesium sulfate The solvent is removed under reduced pressure
ソース ID: ord-0e6c22c4780947d696294e3786e6dc6f反応条件: temp:25.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: Sodium borohydride (1.17 g) is added slowly to a flask containing zirconium tetrachloride (1.8 g) in tetrahydrofuran (27 mL). A solution of 1-(2-trifluoromethyl-phenyl)-ethanone O-methyl-oxime (1.34 g) in tetrahydrofuran (7.7 mL) is added and the resulting solution is stirred at 25° C. for 12 hours. The reaction mixture is then cooled to 0° C. and water (16 mL) is slowly added. Excess ammonium hydroxide is added and the solution is extracted twice with ethyl acetate. The organic portion is washed twice with 1N hydrochloric acid. The aqueous (acid) layer is basified with sodium hydroxide and extracted twice with ethyl acetate. The organic layer is then washed with saturated aqueous sodium chloride and dried over anhydrous magnesium sulfate. The solvent is removed under reduced pressure to provide the desired product as a yellow oil (0.20 g). The reaction mixture is then cooled to 0° C. the solution is extracted twice with ethyl acetate The organic portion is washed twice with 1N hydrochloric acid extracted twice with ethyl acetate The organic layer is then washed with saturated aqueous sodium chloride dried over anhydrous magnesium sulfate The solvent is removed under reduced pressure
ソース ID: ord-0e6c22c4780947d696294e3786e6dc6f反応条件: temp:25.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: Sodium borohydride (1.17 g) is added slowly to a flask containing zirconium tetrachloride (1.8 g) in tetrahydrofuran (27 mL). A solution of 1-(2-trifluoromethyl-phenyl)-ethanone O-methyl-oxime (1.34 g) in tetrahydrofuran (7.7 mL) is added and the resulting solution is stirred at 25° C. for 12 hours. The reaction mixture is then cooled to 0° C. and water (16 mL) is slowly added. Excess ammonium hydroxide is added and the solution is extracted twice with ethyl acetate. The organic portion is washed twice with 1N hydrochloric acid. The aqueous (acid) layer is basified with sodium hydroxide and extracted twice with ethyl acetate. The organic layer is then washed with saturated aqueous sodium chloride and dried over anhydrous magnesium sulfate. The solvent is removed under reduced pressure to provide the desired product as a yellow oil (0.20 g). The reaction mixture is then cooled to 0° C. the solution is extracted twice with ethyl acetate The organic portion is washed twice with 1N hydrochloric acid extracted twice with ethyl acetate The organic layer is then washed with saturated aqueous sodium chloride dried over anhydrous magnesium sulfate The solvent is removed under reduced pressure
ソース ID: ord-407cc49ac6b64d318e0955a94bd911d2反応条件: temp:25.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: Sodium borohydride (1.17 g) is added slowly to a flask containing zirconium tetrachloride (1.8 g) in tetrahydrofuran (27 mL). A solution of 1-(2-trifluoromethyl-phenyl)-ethanone O-methyl-oxime (1.34 g) in tetrahydrofuran (7.7 mL) is added and the resulting solution is stirred at 25° C. for 12 hours. The reaction mixture is then cooled to 0° C. and water (16 mL) is slowly added. Excess ammonium hydroxide is added and the solution is extracted twice with ethyl acetate. The organic portion is washed twice with 1N hydrochloric acid. The aqueous (acid) layer is basified with sodium hydroxide and extracted twice with ethyl acetate. The organic layer is then washed with saturated aqueous sodium chloride and dried over anhydrous magnesium sulfate. The solvent is removed under reduced pressure to provide the desired product as a yellow oil (0.20 g). The reaction mixture is then cooled to 0° C. the solution is extracted twice with ethyl acetate The organic portion is washed twice with 1N hydrochloric acid extracted twice with ethyl acetate The organic layer is then washed with saturated aqueous sodium chloride dried over anhydrous magnesium sulfate The solvent is removed under reduced pressure
ソース ID: ord-1fdcf0bbd2564ef0940884fac4edcba1反応条件: temp:25.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: 5 Sodium borohydride (1.17 g) is added slowly to a flask containing zirconium tetrachloride (1.8 g) in tetrahydrofuran (27 mL). A solution of 1-(2-trifluoromethyl-phenyl)-ethanone O-methyl-oxime (1.34 g) in tetrahydrofuran (7.7 mL) is added and the resulting solution is stirred at 25° C. for 12 hours. The reaction mixture is then cooled to 0° C. and water (16 mL) is slowly added. Excess ammonium hydroxide is added and the solution is extracted twice with ethyl acetate. The organic portion is washed twice with IN hydrochloric acid. The aqueous (acid) layer is basified with sodium hydroxide and extracted twice with ethyl acetate. The organic layer is then washed with saturated aqueous sodium chloride and dried over anhydrous magnesium sulfate. The solvent is removed under reduced pressure to provide the desired product as a yellow oil (0.20 g) The reaction mixture is then cooled to 0° C. the solution is extracted twice with ethyl acetate The organic portion is washed twice with IN hydrochloric acid extracted twice with ethyl acetate The organic layer is then washed with saturated aqueous sodium chloride dried over anhydrous magnesium sulfate The solvent is removed under reduced pressure
ソース ID: ord-f68d87eb7f324c3ea19bc2f1e5eccb06反応条件: temp:25.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: Sodium borohydride (1.17 g) is added slowly to a flask containing zirconium tetrachloride (1.8 g) in tetrahydrofuran (27 mL). A solution of 1-(2-trifluoromethyl-phenyl)-ethanone O-methyl-oxime (1.34 g) in tetrahydrofuran (7.7 mL) is added and the resulting solution is stirred at 25° C. for 12 hours. The reaction mixture is then cooled to 0° C. and water (16 mL) is slowly added. Excess ammonium hydroxide is added and the solution is extracted twice with ethyl acetate. The organic portion is washed twice with 1N hydrochloric acid. The aqueous (acid) layer is basified with sodium hydroxide and extracted twice with ethyl acetate. The organic layer is then washed with saturated aqueous sodium chloride and dried over anhydrous magnesium sulfate. The solvent is removed under reduced pressure to provide the desired product as a yellow oil (0.20 g). The reaction mixture is then cooled to 0° C. the solution is extracted twice with ethyl acetate The organic portion is washed twice with 1N hydrochloric acid extracted twice with ethyl acetate The organic layer is then washed with saturated aqueous sodium chloride dried over anhydrous magnesium sulfate The solvent is removed under reduced pressure
ソース ID: ord-774a45b8eaa04f5bb093ceb700f6a576反応条件: temp:25.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: Sodium borohydride (1.17 g) is added slowly to a flask containing zirconium tetrachloride (1.8 g) in tetrahydrofuran (27 mL). A solution of 1-(2-trifluoromethyl-phenyl)-ethanone O-methyl-oxime (1.34 g) in tetrahydrofuran (7.7 mL) is added and the resulting solution is stirred at 25° C. for 12 hours. The reaction mixture is then cooled to 0° C. and water (16 mL) is slowly added. Excess ammonium hydroxide is added and the solution is extracted twice with ethyl acetate. The organic portion is washed twice with 1N hydrochloric acid. The aqueous (acid) layer is basified with sodium hydroxide and extracted twice with ethyl acetate. The organic layer is then washed with saturated aqueous sodium chloride and dried over anhydrous magnesium sulfate. The solvent is removed under reduced pressure to provide the desired product as a yellow oil (0.20 g). The reaction mixture is then cooled to 0° C. the solution is extracted twice with ethyl acetate The organic portion is washed twice with 1N hydrochloric acid extracted twice with ethyl acetate The organic layer is then washed with saturated aqueous sodium chloride dried over anhydrous magnesium sulfate The solvent is removed under reduced pressure
ソース ID: ord-14a1e8e04be849c9998f38d1254365c0反応条件: temp:25.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: Sodium borohydride (1.17 g) is added slowly to a flask containing zirconium tetrachloride (1.8 g) in tetrahydrofuran (27 mL). A solution of 1-(2-trifluoromethyl-phenyl)-ethanone O-methyl-oxime (1.34 g) in tetrahydrofuran (7.7 mL) is added and the resulting solution is stirred at 25° C. for 12 hours. The reaction mixture is then cooled to 0° C. and water (16 mL) is slowly added. Excess ammonium hydroxide is added and the solution is extracted twice with ethyl acetate. The organic portion is washed twice with 1N hydrochloric acid. The aqueous (acid) layer is basified with sodium hydroxide and extracted twice with ethyl acetate. The organic layer is then washed with saturated aqueous sodium chloride and dried over anhydrous magnesium sulfate. The solvent is removed under reduced pressure to provide the desired product as a yellow oil (0.20 g). The reaction mixture is then cooled to 0° C. the solution is extracted twice with ethyl acetate The organic portion is washed twice with 1N hydrochloric acid extracted twice with ethyl acetate The organic layer is then washed with saturated aqueous sodium chloride dried over anhydrous magnesium sulfate The solvent is removed under reduced pressure
ソース ID: ord-bf198f1bc95f4917a42738ced1ef6e3dPubChem References
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