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C1CSCCC1I製品情報
4-iodothiane (CAS 281204-90-8) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
想定用途
専門的研究・工業用途限定
データベース ID 18525911
安全上の注意
For professional research and industrial use only. Review the supplier safety data sheet before handling.
合成データ
6 反応 · 6 文献
反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-25eced285fb645df8f6be1ee801d8c6d反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-25eced285fb645df8f6be1ee801d8c6d反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-25eced285fb645df8f6be1ee801d8c6d反応条件: temp:80.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: To a solution of 5-chloro-N2-(2,5-dimethyl-4-(piperidin-4-yl)phenyl)-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (30 mg, 0.073 mmol) in acetonitrile (1 mL) was added Cs2CO3 (47 mg, 0.15 mmol) and 4-iodotetrahydro-2H-thiopyran (48 mg, 0.22 mmol). This mixture was then stirred at 80° C. for 16 hr. After cooling down to room temperature, the mixture was treated with saturated aqueous NH4Cl solution (3 mL) and extracted with EtOAc (3×3 mL). The organic layers were combined and concentrated. The residue was purified by silica gel chromatography (Gradient 0˜8% MeOH/CH2Cl2 with NH3) to provide 5-chloro-N2-(2,5-dimethyl-4-(1-(tetrahydro-2H-thiopyran-4-yl)piperidin-4-yl)phenyl)-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine as a white solid. ESMS m/z 512.2 (M+H+). After cooling down to room temperature extracted with EtOAc (3×3 mL) concentrated The residue was purified by silica gel chromatography (Gradient 0˜8% MeOH/CH2Cl2 with NH3)
ソース ID: ord-338c3a76b2e54aacb0611f76936c8ef4反応条件: temp:80.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: To a solution of 5-chloro-N2-(2,5-dimethyl-4-(piperidin-4-yl)phenyl)-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (30 mg, 0.073 mmol) in acetonitrile (1 mL) was added Cs2CO3 (47 mg, 0.15 mmol) and 4-iodotetrahydro-2H-thiopyran (48 mg, 0.22 mmol). This mixture was then stirred at 80° C. for 16 hr. After cooling down to room temperature, the mixture was treated with saturated aqueous NH4Cl solution (3 mL) and extracted with EtOAc (3×3 mL). The organic layers were combined and concentrated. The residue was purified by silica gel chromatography (Gradient 0˜8% MeOH/CH2Cl2 with NH3) to provide 5-chloro-N2-(2,5-dimethyl-4-(1-(tetrahydro-2H-thiopyran-4-yl)piperidin-4-yl)phenyl)-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine as a white solid. ESMS m/z 512.2 (M+H+). After cooling down to room temperature extracted with EtOAc (3×3 mL) concentrated The residue was purified by silica gel chromatography (Gradient 0˜8% MeOH/CH2Cl2 with NH3)
ソース ID: ord-8b3cf5677340480abd95eeb30d722d87反応条件: temp:80.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: To a solution of 5-chloro-N2-(2,5-dimethyl-4-(piperidin-4-yl)phenyl)-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (30 mg, 0.073 mmol) in acetonitrile (1 mL) was added Cs2CO3 (47 mg, 0.15 mmol) and 4-iodotetrahydro-2H-thiopyran (48 mg, 0.22 mmol). This mixture was then stirred at 80° C. for 16 hr. After cooling down to room temperature, the mixture was treated with saturated aqueous NH4Cl solution (3 mL) and extracted with EtOAc (3×3 mL). The organic layers were combined and concentrated. The residue was purified by silica gel chromatography (Gradient 0˜8% MeOH/CH2Cl2 with NH3) to provide 5-chloro-N2-(2,5-dimethyl-4-(1-(tetrahydro-2H-thiopyran-4-yl)piperidin-4-yl)phenyl)-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine as a white solid. ESMS m/z 512.2 (M+H+). After cooling down to room temperature extracted with EtOAc (3×3 mL) concentrated The residue was purified by silica gel chromatography (Gradient 0˜8% MeOH/CH2Cl2 with NH3)
ソース ID: ord-338c3a76b2e54aacb0611f76936c8ef4PubChem References
化合物の公開データベース記録に掲載された情報源です。