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C1CNC(CN1)CO製品情報
piperazin-2-ylmethanol (CAS 28795-50-8) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
想定用途
専門的研究・工業用途限定
データベース ID 11788288
安全上の注意
For professional research and industrial use only. Review the supplier safety data sheet before handling.
合成データ
12 反応 · 12 文献
反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-30bde693615b45d890b93d03a7122179反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-96eb1b5c72fc48bc81cab929fb019c3f反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: Following a procedure similar to that described in Preparation 8, but using 10.0 g of (2S,4S)-4-(4-methoxybenzylthio)-1-(4-nitrobenzyloxycarbonyl)-2-pyrrolidinecarboxylic acid, 4.4 g of N,N'-carbonyldiimidazole and 4.0 g of 2-hydroxymethylpiperazine, 6.9 g of the title compound were obtained, as a powder. that described in Preparation 8
ソース ID: ord-eed6d9c61d834727a20f1d86b7fa8fed反応条件: temp:130.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: A mixture of 2 g of 2-hydroxymethylpiperazine, 1 g of 7-chloro-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid and 8 ml of pyridine was heated at 130° C. in a sealed bottle, under argon, overnight. The solvent was removed and the residue adsorbed onto silica gel, then added to a column of flash grade silica gel. The column was eluted with methanol:water (95:5). The product fraction was collected, dissolved in methanoldichloromethane and converted to the hydrochloride salt, mp>275° C. The solvent was removed added to a column of flash grade silica gel The column was eluted with methanol:water (95:5) The product fraction was collected dissolved in methanoldichloromethane
ソース ID: ord-0e7d464895b94570a0d7b9c91f1bdccd反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: Following a procedure similar to that described in Preparation 8, but using 10.0 g of (2S,4S)-4-(4-methoxybenzylthio)-1-(4-nitrobenzyloxycarbonyl)-2-pyrrolidinecarboxylic acid, 4.4 g of N,N'-carbonyldiimidazole and 4.0 g of 2-hydroxymethylpiperazine, 6.9 g of the title compound were obtained, as a powder. that described in Preparation 8
ソース ID: ord-aac61d426ebd406eaea7aa2c717b9d49反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: Following a procedure similar to that described in Preparation 8, but using 10.0 g of (2S,4S)-4-(4-methoxybenzylthio)-1-(4-nitrobenzyloxycarbonyl)-2-pyrrolidinecarboxylic acid, 4.4 g of N,N'-carbonyldiimidazole and 4.0 g of 2-hydroxymethylpiperazine, 6.9 g of the title compound were obtained, as a powder. that described in Preparation 8
ソース ID: ord-aac61d426ebd406eaea7aa2c717b9d49反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: B13 was prepared following the procedure reported for B1 using A1 and rac-2-(hydroxymethyl)piperazine. MS (ES) C15H21N7O3S requires: 379. found: 380 (M+H)+. B13 was prepared
ソース ID: ord-3e2e7ef0c7134ccfba4a21ef0af0a8ef反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: B13 was prepared following the procedure reported for B1 using A1 and rac-2-(hydroxymethyl)piperazine. MS (ES) C15H21N7O3S requires: 379. found: 380 (M+H)+. B13 was prepared
ソース ID: ord-3e2e7ef0c7134ccfba4a21ef0af0a8ef反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: Following a procedure similar to that described in Preparation 8, but using 10.0 g of (2S,4S)-4-(4-methoxybenzylthio)-1-(4-nitrobenzyloxycarbonyl)-2-pyrrolidinecarboxylic acid, 4.4 g of N,N'-carbonyldiimidazole and 4.0 g of 2-hydroxymethylpiperazine, 6.9 g of the title compound were obtained, as a powder. that described in Preparation 8
ソース ID: ord-eed6d9c61d834727a20f1d86b7fa8fed反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: Following a procedure similar to that described in Preparation 8, but using 10.0 g of (2S,4S)-4-(4-methoxybenzylthio)-1-(4-nitrobenzyloxycarbonyl)-2-pyrrolidinecarboxylic acid, 4.4 g of N,N'-carbonyldiimidazole and 4.0 g of 2-hydroxymethylpiperazine, 6.9 g of the title compound were obtained, as a powder. that described in Preparation 8
ソース ID: ord-eed6d9c61d834727a20f1d86b7fa8fed反応条件: temp:130.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: A mixture of 2 g of 2-hydroxymethylpiperazine, 1 g of 7-chloro-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid and 8 ml of pyridine was heated at 130° C. in a sealed bottle, under argon, overnight. The solvent was removed and the residue adsorbed onto silica gel, then added to a column of flash grade silica gel. The column was eluted with methanol:water (95:5). The product fraction was collected, dissolved in methanoldichloromethane and converted to the hydrochloride salt, mp>275° C. The solvent was removed added to a column of flash grade silica gel The column was eluted with methanol:water (95:5) The product fraction was collected dissolved in methanoldichloromethane
ソース ID: ord-0e7d464895b94570a0d7b9c91f1bdccd反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-30bde693615b45d890b93d03a7122179PubChem References
化合物の公開データベース記録に掲載された情報源です。