4,4-dimethylpyrazolidin-3-one

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 4,4-dimethyl-3-pyrazolidinone [1.42 g] and benzyl bromide [1.78 mL] and NaHCO3 [1.26 g] were combined in 5 mL ethanol. The mixture was heated at reflux for 30 minutes. The reaction mixture was cooled to room temperature, diluted with diethyl ether (50 mL), dried with MgSO4, filtered and evaporated. The resulting oil was chromatographed on silica gel to yield 1.22 g (52%) of 1-Benzyl-4,4-dimethyl-3-pyrazolidinone as a light oil. 1H NMR: 7.6-7.2 (5H, m), 3.8-3.4 (4H, m), 1.2 (6H, s). The mixture was heated at reflux for 30 minutes dried with MgSO4 filtered evaporated The resulting oil was chromatographed on silica gel