2-bromocyclododecan-1-one

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Reaction of α-bromocyclododecanone VI with the dialkyl ester of sodium malonic acid to obtain the dialkyl ester of 2-(2-oxocyclododec-1-yl)malonic acid VII.

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Reaction of α-bromocyclododecanone VI with the dialkyl ester of sodium malonic acid to obtain the dialkyl ester of 2-(2-oxocyclododec-1-yl)malonic acid VII.

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: reacting α-bromocyclododecanone with sodium malonic acid dimethyl ester in methanol at from about 10° to 40° C. to form 2-(2-oxocyclododec-1-yl)-malonic acid dimethyl ester; at from about 10° to 40° C.

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: reacting cyclododecanone with elemental bromine in boiling methylene chloride to form α-bromocyclododecanone;

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: An amount of 183.8 gm (1.15 mol) of bromine was added dropwise with refluxing under a nitrogen atmosphere to a well agitated solution comprising 182.3 gm (1 mol) of cyclododecanone in 275 ml of methylene chloride over a period of six hours. Agitation was continued for 15 minutes and approximately one-half of the solvent was distilled off. The solution obtained by this method contained approximately 235 gm of α-bromocyclododecanone (90% yield) and was further reacted directly. with refluxing under a nitrogen atmosphere to a well agitated solution of six hours approximately one-half of the solvent was distilled off The solution obtained by this method

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Reaction of α-bromocyclododecanone VI with the dialkyl ester of sodium malonic acid to obtain the dialkyl ester of 2-(2-oxocyclododec-1-yl)malonic acid VII.