N-(2,4-difluorophenyl)-2-methoxybenzamide

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: To a solution of compound 3a (0.50 g, 2 mmole) in anhydrous acetone (10 mL) were added potassium carbonate (0.69 g, 5 mmole) and iodomethane (0.28 mL, 4.4 mmol) and refluxed 8 hr. After cooled to room temperature, the reaction mixture was filtered through Celite and concentrated. The residue was extracted with ethyl acetate and dried over anhydrous magnesium sulfate, then concentrated and recrystallized with hot methanol. refluxed 8 hr the reaction mixture was filtered through Celite concentrated The residue was extracted with ethyl acetate dried over anhydrous magnesium sulfate concentrated recrystallized with hot methanol