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CC(C)NNC(=O)OC製品情報
methyl N-(propan-2-ylamino)carbamate (CAS 31457-71-3) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
想定用途
専門的研究・工業用途限定
データベース ID 57863323
安全上の注意
For professional research and industrial use only. Review the supplier safety data sheet before handling.
合成データ
12 反応 · 12 文献
反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-b35d93f197614ab9998b359c1600c52f反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-d54637179cf94589bffdde3817216fcd反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-e769a70bbbfd4b9cb8201706cfd325e9反応条件: temp:0.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: Triphosgene (1.05 g) was dissolved in DCM (17 mL) and stirred at 0° C. N′-Isopropyl-hydrazine-carboxylic acid methyl ester (1.00 g) and DIPEA (1.5 mL) were dissolved in DCM (25 mL), and mixture was added to triphosgene solution and stirred for 10 minutes. 5-(4-Bromo-phenyl)-2-pyrrolidin-2-yl-1H-imidazole (2.65 g) was added. Reaction was stirred at room temperature for 1 hour and extracted twice with water (10 mL), once with brine (10 mL), and evaporated under vacuum. The resulting oil was subjected to silica gel chromatography using a 40 g ISCO column and effluent of 0-100% ethyl acetate:hexanes. The fractions containing product were combined and the solvent was removed under vacuum, giving N′-{2-[5-(4-Bromo-phenyl)-1H-imidazol-2-yl]-pyrrolidine-1-carbonyl}-N′-isopropyl-hydrazine-carboxylic acid methyl ester (533 mg, 16%). stirred for 10 minutes Reaction was stirred at room temperature for 1 hour extracted twice with water (10 mL), once with brine (10 mL) evaporated under vacuum The fractions containing product the solvent was removed under vacuum
ソース ID: ord-bee61f2e6526477a82092aa5eb90bb80反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: N′-Isopropylidene-hydrazine-carboxylic acid methyl ester (6.45 g) were dissolved in ethanol (50 mL) and acetic acid (50 mL). PtO2 (0.231 g) was added, and reaction was stirred at room temperature for 22 hours under an atmosphere of hydrogen. Mixture was evaporated under vacuum, giving N′-Isopropyl-hydrazine-carboxylic acid methyl ester (5.08 g, 77%) as a white solid. reaction Mixture was evaporated under vacuum
ソース ID: ord-3d4be84114a5432786f6919c3c67770e反応条件: temp:0.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: Triphosgene (1.05 g) was dissolved in DCM (17 mL) and stirred at 0° C. N′-Isopropyl-hydrazine-carboxylic acid methyl ester (1.00 g) and DIPEA (1.5 mL) were dissolved in DCM (25 mL), and mixture was added to triphosgene solution and stirred for 10 minutes. 5-(4-Bromo-phenyl)-2-pyrrolidin-2-yl-1H-imidazole (2.65 g) was added. Reaction was stirred at room temperature for 1 hour and extracted twice with water (10 mL), once with brine (10 mL), and evaporated under vacuum. The resulting oil was subjected to silica gel chromatography using a 40 g ISCO column and effluent of 0-100% ethyl acetate:hexanes. The fractions containing product were combined and the solvent was removed under vacuum, giving N′-{2-[5-(4-Bromo-phenyl)-1H-imidazol-2-yl]-pyrrolidine-1-carbonyl}-N′-isopropyl-hydrazine-carboxylic acid methyl ester (533 mg, 16%). stirred for 10 minutes Reaction was stirred at room temperature for 1 hour extracted twice with water (10 mL), once with brine (10 mL) evaporated under vacuum The fractions containing product the solvent was removed under vacuum
ソース ID: ord-bee61f2e6526477a82092aa5eb90bb80反応条件: temp:0.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: Triphosgene (1.05 g) was dissolved in DCM (17 mL) and stirred at 0° C. N′-Isopropyl-hydrazine-carboxylic acid methyl ester (1.00 g) and DIPEA (1.5 mL) were dissolved in DCM (25 mL), and mixture was added to triphosgene solution and stirred for 10 minutes. 5-(4-Bromo-phenyl)-2-pyrrolidin-2-yl-1H-imidazole (2.65 g) was added. Reaction was stirred at room temperature for 1 hour and extracted twice with water (10 mL), once with brine (10 mL), and evaporated under vacuum. The resulting oil was subjected to silica gel chromatography using a 40 g ISCO column and effluent of 0-100% ethyl acetate:hexanes. The fractions containing product were combined and the solvent was removed under vacuum, giving N′-{2-[5-(4-Bromo-phenyl)-1H-imidazol-2-yl]-pyrrolidine-1-carbonyl}-N′-isopropyl-hydrazine-carboxylic acid methyl ester (533 mg, 16%). stirred for 10 minutes Reaction was stirred at room temperature for 1 hour extracted twice with water (10 mL), once with brine (10 mL) evaporated under vacuum The fractions containing product the solvent was removed under vacuum
ソース ID: ord-bee61f2e6526477a82092aa5eb90bb80反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: N′-Isopropylidene-hydrazine-carboxylic acid methyl ester (6.45 g) were dissolved in ethanol (50 mL) and acetic acid (50 mL). PtO2 (0.231 g) was added, and reaction was stirred at room temperature for 22 hours under an atmosphere of hydrogen. Mixture was evaporated under vacuum, giving N′-Isopropyl-hydrazine-carboxylic acid methyl ester (5.08 g, 77%) as a white solid. reaction Mixture was evaporated under vacuum
ソース ID: ord-3d4be84114a5432786f6919c3c67770e反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: N′-Isopropylidene-hydrazine-carboxylic acid methyl ester (6.45 g) were dissolved in ethanol (50 mL) and acetic acid (50 mL). PtO2 (0.231 g) was added, and reaction was stirred at room temperature for 22 hours under an atmosphere of hydrogen. Mixture was evaporated under vacuum, giving N′-Isopropyl-hydrazine-carboxylic acid methyl ester (5.08 g, 77%) as a white solid. reaction Mixture was evaporated under vacuum
ソース ID: ord-3d4be84114a5432786f6919c3c67770e反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-d54637179cf94589bffdde3817216fcd反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-e769a70bbbfd4b9cb8201706cfd325e9反応条件: temp:0.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: Triphosgene (1.05 g) was dissolved in DCM (17 mL) and stirred at 0° C. N′-Isopropyl-hydrazine-carboxylic acid methyl ester (1.00 g) and DIPEA (1.5 mL) were dissolved in DCM (25 mL), and mixture was added to triphosgene solution and stirred for 10 minutes. 5-(4-Bromo-phenyl)-2-pyrrolidin-2-yl-1H-imidazole (2.65 g) was added. Reaction was stirred at room temperature for 1 hour and extracted twice with water (10 mL), once with brine (10 mL), and evaporated under vacuum. The resulting oil was subjected to silica gel chromatography using a 40 g ISCO column and effluent of 0-100% ethyl acetate:hexanes. The fractions containing product were combined and the solvent was removed under vacuum, giving N′-{2-[5-(4-Bromo-phenyl)-1H-imidazol-2-yl]-pyrrolidine-1-carbonyl}-N′-isopropyl-hydrazine-carboxylic acid methyl ester (533 mg, 16%). stirred for 10 minutes Reaction was stirred at room temperature for 1 hour extracted twice with water (10 mL), once with brine (10 mL) evaporated under vacuum The fractions containing product the solvent was removed under vacuum
ソース ID: ord-1f8a8a2855f74cd48d84cde69e8738dbPubChem References
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