2-morpholin-4-yl-2-phenylethanamine

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Following the procedure (preparation of rac-±-(2-chloro-3-trifluoromethyl-benzyl)-(trifluoro-phenyl-propyl)-amine) of Example 64, step (a) except rac-±-2-Morpholin4-yl-2-phenyl-ethylamine was used in step (a) instead of 2-chloro-3-(α,α,α-trifluoromethyl)benzylamine, and 2-chloro-3-trifluoromethyl benzaldehyde was used instead of (α,α,α-trifluoromethylphenylacetaldehyde, the title compound was sythesized as an oil, 0.27 g (88%); MS (ESI) 399 (M+H+).

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Following the procedure (preparation of rac-±-(2-chloro-3-trifluoromethyl-benzyl)-(trifluoro-phenyl-propyl)-amine) of Example 64, step (a) except rac-±-2-Morpholin4-yl-2-phenyl-ethylamine was used in step (a) instead of 2-chloro-3-(α,α,α-trifluoromethyl)benzylamine, and 2-chloro-3-trifluoromethyl benzaldehyde was used instead of (α,α,α-trifluoromethylphenylacetaldehyde, the title compound was sythesized as an oil, 0.27 g (88%); MS (ESI) 399 (M+H+).

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Similar procedure as described in example 1b was used, starting from 2-methylsulfanyl-5-[1-quinolin-6-yl-meth-(Z)-ylidene]-thiazol-4-one, 2-morpholin-4-yl-2-phenyl-ethylamine and DIEA to give 2-(2-morpholin-4-yl-2-phenyl-ethylamino)-5-[1-quinolin-6-yl-meth-(Z)-ylidene]-thiazol-4-one. LC-MS m/e 445 (MH+).

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Following the procedure (preparation of rac-±-(2-chloro-3-trifluoromethyl-benzyl)-(trifluoro-phenyl-propyl)-amine) of Example 64, step (a) except rac-±-2-Morpholin4-yl-2-phenyl-ethylamine was used in step (a) instead of 2-chloro-3-(α,α,α-trifluoromethyl)benzylamine, and 2-chloro-3-trifluoromethyl benzaldehyde was used instead of (α,α,α-trifluoromethylphenylacetaldehyde, the title compound was sythesized as an oil, 0.27 g (88%); MS (ESI) 399 (M+H+).