2-[2-aminoethyl(2-hydroxyethyl)amino]ethanol

反応条件: temp:0.00; pressure:0.00; stir:

反応条件: temp:0.00; pressure:0.00; stir:

反応条件: temp:0.00; pressure:0.00; stir:

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A mixture of N,N-dioctadecylcarbamyl chloride (2.9 g.), N,N-bis-(2-hydroxyethyl)-1,2-ethanediamine (4.0 g.) and benzene (50 ml.) is refluxed and stirred for three hours. The mixture is then cooled, concentrated in vacuo and the residue taken up on chloroform (100 ml.). The chloroform solution is washed successively with water (2 × 50 ml.), aqueous sodium hydroxide (1 × 50 ml. of 1N) and water (2 × 50 ml.), then dried (Na2SO4). Removal of the chloroform in vacuo leaves the crude product as an oil (3.3 g.). is refluxed The mixture is then cooled concentrated in vacuo The chloroform solution is washed successively with water (2 × 50 ml.), aqueous sodium hydroxide (1 × 50 ml. of 1N) and water (2 × 50 ml.) dried (Na2SO4) Removal of the chloroform in vacuo

反応条件: temp:0.00; pressure:0.00; stir:

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A mixture of N,N-dioctadecylcarbamyl chloride (2.9 g.), N,N-bis(2-hydroxyethyl)-1,2-ethanediamine (4.0 g.) and benzene (50 ml.) is refluxed and stirred for three hours. The mixture is then cooled, concentrated in vacuo and the residue taken up on chloroform (100 ml.). The chloroform solution is washed successively with water (2× 50 ml.), aqueous sodium hydroxide (1× 50 ml. of 1 N) and water (2× 50 ml.), then dried (Na2SO4). Removal of the chloroform in vacuo leaves the crude product as an oil (3.3 g.). is refluxed The mixture is then cooled concentrated in vacuo The chloroform solution is washed successively with water (2× 50 ml.), aqueous sodium hydroxide (1× 50 ml. of 1 N) and water (2× 50 ml.) dried (Na2SO4) Removal of the chloroform in vacuo

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A mixture of N,N-dioctadecylcarbamyl chloride (2.9 g.), N,N-bis(2-hydroxyethyl)-1,2-ethanediamine (4.0 g.) and benzene (50 ml.) is refluxed and stirred for three hours. The mixture is then cooled, concentrated in vacuo and the residue taken up on chloroform (100 ml.). The chloroform solution is washed successively with water (2× 50 ml.), aqueous sodium hydroxide (1× 50 ml. of 1 N) and water (2× 50 ml.), then dried (Na2SO4). Removal of the chloroform in vacuo leaves the crude product as an oil (3.3 g.). is refluxed The mixture is then cooled concentrated in vacuo The chloroform solution is washed successively with water (2× 50 ml.), aqueous sodium hydroxide (1× 50 ml. of 1 N) and water (2× 50 ml.) dried (Na2SO4) Removal of the chloroform in vacuo

反応条件: temp:60.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 5 g of para-fluoronitrobenzene were added to a solution of 60 ml of N-methylpyrrolidinone, 6.29 g of N,N-bis(2-hydroxyethyl)ethylenediamine, and 4.3 g of triethylamine. The reaction medium was heated at 60° C. for 15 hours and, after cooling to room temperature, was poured into a water/ice mixture. A yellow precipitate formed, which was filtered off, reslurried in water, and then dried over P2O5. 7.5 g of 2-[[2-(4-nitrophenylamino)ethyl]-(2-hydroxyethyl)amino]ethanol (19) were obtained. after cooling to room temperature A yellow precipitate formed which was filtered off dried over P2O5

反応条件: temp:80.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 2 g of 2-fluoro-5-nitrotoluene were added to a solution of 30 ml of N-methylpyrrolidinone, 2.29 g of N,N-bis(2-hydroxyethyl)ethylenediamine, and 1.72 g of triethylamine. The reaction medium was heated at 80° C. for 10 hours and, after cooling to room temperature, was poured into a water/ice mixture. The resulting medium was extracted with ethyl acetate and the organic phase was then concentrated under vacuum. 1.5 g of 2[[2-(4-nitro-2-methylphenylamino)ethyl]-(2-hydroxyethyl)amino]ethanol (17) were obtained. after cooling to room temperature The resulting medium was extracted with ethyl acetate the organic phase was then concentrated under vacuum

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A mixture of N,N-dioctadecylcarbamyl chloride (2.9 g.), N,N-bis-(2-hydroxyethyl)-1,2-ethanediamine (4.0 g.) and benzene (50 ml.) is refluxed and stirred for three hours. The mixture is then cooled, concentrated in vacuo and the residue taken up on chloroform (100 ml.). The chloroform solution is washed successively with water (2 × 50 ml.), aqueous sodium hydroxide (1 × 50 ml. of 1N) and water (2 × 50 ml.), then dried (Na2SO4). Removal of the chloroform in vacuo leaves the crude product as an oil (3.3 g.). is refluxed The mixture is then cooled concentrated in vacuo The chloroform solution is washed successively with water (2 × 50 ml.), aqueous sodium hydroxide (1 × 50 ml. of 1N) and water (2 × 50 ml.) dried (Na2SO4) Removal of the chloroform in vacuo

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A mixture of N,N-dioctadecylcarbamyl chloride (2.9 g.), N,N-bis-(2-hydroxyethyl)-1,2-ethanediamine (4.0 g.) and benzene (50 ml.) is refluxed and stirred for three hours. The mixture is then cooled, concentrated in vacuo and the residue taken up on chloroform (100 ml.). The chloroform solution is washed successively with water (2 × 50 ml.), aqueous sodium hydroxide (1 × 50 ml. of 1N) and water (2 × 50 ml.), then dried (Na2SO4). Removal of the chloroform in vacuo leaves the crude product as an oil (3.3 g.). is refluxed The mixture is then cooled concentrated in vacuo The chloroform solution is washed successively with water (2 × 50 ml.), aqueous sodium hydroxide (1 × 50 ml. of 1N) and water (2 × 50 ml.) dried (Na2SO4) Removal of the chloroform in vacuo

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A mixture of N,N-dioctadecylcarbamyl chloride (2.9 g.), N,N-bis(2-hydroxyethyl)-1,2-ethanediamine (4.0 g.) and benzene (50 ml.) is refluxed and stirred for three hours. The mixture is then cooled, concentrated in vacuo and the residue taken up on chloroform (100 ml.). The chloroform solution is washed successively with water (2× 50 ml.), aqueous sodium hydroxide (1× 50 ml. of 1 N) and water (2× 50 ml.), then dried (Na2SO4). Removal of the chloroform in vacuo leaves the crude product as an oil (3.3 g.). is refluxed The mixture is then cooled concentrated in vacuo The chloroform solution is washed successively with water (2× 50 ml.), aqueous sodium hydroxide (1× 50 ml. of 1 N) and water (2× 50 ml.) dried (Na2SO4) Removal of the chloroform in vacuo