N-[1-(4-fluorophenyl)ethylidene]hydroxylamine

反応条件: temp:20.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A mixture of 1-(4-fluorophenyl)ethanone oxime (8.00 g) and caesium carbonate (20.4 g) in acetonitrile was stirred at 20° C. for 30 minutes. Then ethyl bromoacetate (12.2 g) and potassium iodide (8.7 g) were added thereto and the mixture was stirred at 82° C. for 3 hours. Then the reaction mixture was filtered. The solvent was removed from the filtrate under reduced pressure. Purification by column chromatography gave ethyl({[1-(4-fluorophenyl)ethylidene]amino}oxy)acetate (8.7 g). the mixture was stirred at 82° C. for 3 hours Then the reaction mixture was filtered The solvent was removed from the filtrate under reduced pressure Purification by column chromatography

反応条件: temp:20.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A mixture of 1-(4-fluorophenyl)ethanone oxime (8.00 g) and caesium carbonate (20.4 g) in acetonitrile was stirred at 20° C. for 30 minutes. Then ethyl bromoacetate (12.2 g) and potassium iodide (8.7 g) were added thereto and the mixture was stirred at 82° C. for 3 hours. Then the reaction mixture was filtered. The solvent was removed from the filtrate under reduced pressure. Purification by column chromatography gave ethyl({[1-(4-fluorophenyl)ethylidene]amino}oxy)acetate (8.7 g). the mixture was stirred at 82° C. for 3 hours Then the reaction mixture was filtered The solvent was removed from the filtrate under reduced pressure Purification by column chromatography

反応条件: temp:20.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A mixture of 1-(4-fluorophenyl)ethanone oxime (8.00 g) and caesium carbonate (20.4 g) in acetonitrile was stirred at 20° C. for 30 minutes. Then ethyl bromoacetate (12.2 g) and potassium iodide (8.7 g) were added thereto and the mixture was stirred at 82° C. for 3 hours. Then the reaction mixture was filtered. The solvent was removed from the filtrate under reduced pressure. Purification by column chromatography gave ethyl({[1-(4-fluorophenyl)ethylidene]amino}oxy)acetate (8.7 g). the mixture was stirred at 82° C. for 3 hours Then the reaction mixture was filtered The solvent was removed from the filtrate under reduced pressure Purification by column chromatography