1,4,7,10,13-Pentaoxa-16-azacyclooctadecane

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Analogously to Example 14 from 1-aza-4,7,10,13,16-pentaoxacyclooctadecane and 3,3-dimethylbutyryl chloride.

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Analogously to Example 14 from 1-aza-4,7,10,13,16-pentaoxacyclooctadecane and 2,2-dimethylbutyryl chloride.

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Analogously to Example 14 from 1-aza-4,7,10,13,16-pentaoxacyclooctadecane and (1-adamantyl) acetyl chloride.

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Analogously to Example 14 from 1-aza-4,7,10,13,16-pentaoxacyclooctadecane and 1-adamantylcarbonyl chloride.

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Analogously to Example 14 from 1-aza-4,7,10,13,16-pentaoxacyclooctadecane and pivalyl chloride.

反応条件: temp:80.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A mixture of 26.3 g of 1-aza-18-crown-6, 19.9 g of 2-chloroethyl benzoate, 21.0 g of potassium carbonate, and 60 g of N,N-dimethylformamide was stirred for 10 hours at 80° C. The reaction mixture was subjected to conventional aqueous work-up and purification by column chromatography. There was obtained 320 g of 2-(1,4,7,10,13-pentaoxa-16-azacyclo-octadecan-16-yl)ethyl benzoate (yield 75%). The reaction mixture was subjected to conventional aqueous work-up and purification by column chromatography