1,4-dichloro-2-fluorobenzene

反応条件: temp:0.00; pressure:0.00; stir:

反応条件: temp:0.00; pressure:0.00; stir:

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: The title compound was prepared according to the method of Example 3 step (b) but using 2,5-dichlorofluorobenzene and (3-hydroxyhexyl)methylcarbamic acid, 1,1-dimethylethyl ester.

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 1,4-Dichloro-2-fluorobenzene (165 mg, 1.00 mmol) and (3-cyclopropyl-3-hydroxypropyl)methylcarbamic acid, 1,1-dimethylethyl ester (230 mg, 1.00 mmol) were dissolved in dimethylsulfoxide (10 ml) under nitrogen at room temperature. To the resulting solution was added sodium hydride (60% in oil) (80 mg, 2.00 mmol). The solution was then allowed to stir at room temperature under nitrogen for 24 h. The mixture was then poured into water and extracted with diethyl ether three times. The combined organic fractions were washed with brine and dried over magnesium sulfate. The solvent was evaporated and the residue eluted down a flash chromatography column using 10% ethyl acetate/isohexane as eluent to give 175 mg (47%) of the title compound as an oil. extracted with diethyl ether three times The combined organic fractions were washed with brine dried over magnesium sulfate The solvent was evaporated the residue eluted down a flash chromatography column

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: The title compound was prepared from the product from Example 56 (b) and 1,4-dichloro-2-fluoro-benzene using similar procedures to Example 56 (c). Final purification was by recrystallisation (2-propanol/methanol/diethyl ether) to afford a beige solid. Final purification was by recrystallisation (2-propanol/methanol/diethyl ether) to afford a beige solid

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: The same method as in Example 3 was conducted using 7-methyl-5,6,7,8-tetrahydro-4H-furo[2,3-c]azepin-4-ol (Reference Example 19) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 2,5-dichloro-1-fluorobenzene instead of 1,3-difluorobenzene to give the objective compound. to give the objective compound