2,2,3,3,3-pentafluoropropanamide

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A mixture of 2,2,3,3,3-pentafluoropropanamide (2 g), Lawesson's reagent (2.98 g) and THF (30 ml) was heated under reflux overnight. Then ethyl 3-bromo-2-oxopropanoate (2.99 g) was added, and the mixture was heated at the same temperature overnight. The mixture was poured into water, and extracted with EtOAc. The extract was washed with brine, dried over MgSO4, concentrated in vacuo, and purified by silica gel column chromatography (hexane/EtOAc) to give the title compound (0.91 g) as a yellow solid. was heated under reflux overnight the mixture was heated at the same temperature overnight extracted with EtOAc The extract was washed with brine dried over MgSO4 concentrated in vacuo purified by silica gel column chromatography (hexane/EtOAc)

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A mixture of 2,2,3,3,3-pentafluoropropanamide (2 g), Lawesson's reagent (2.98 g) and THF (30 ml) was heated under reflux overnight. Then ethyl 3-bromo-2-oxopropanoate (2.99 g) was added, and the mixture was heated at the same temperature overnight. The mixture was poured into water, and extracted with EtOAc. The extract was washed with brine, dried over MgSO4, concentrated in vacuo, and purified by silica gel column chromatography (hexane/EtOAc) to give the title compound (0.91 g) as a yellow solid. was heated under reflux overnight the mixture was heated at the same temperature overnight extracted with EtOAc The extract was washed with brine dried over MgSO4 concentrated in vacuo purified by silica gel column chromatography (hexane/EtOAc)