1-(cyclopropylmethyl)piperidin-4-amine

反応条件: temp:0.00; pressure:0.00; stir:

反応条件: temp:0.00; pressure:0.00; stir:

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 5-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)thiophene-2-sulfonyl chloride is reacted with (1-cyclopropylmethylpiperidin-4-yl)amine as described in Steps 5 and 6, Example 24 to give the title compound as a white solid (58% yield). LC/MS: RT 2.07 min; m/e 436; 1H NMR (δ, ppm): 11.85 (1H, br), 10.18 (1H, br), 8.30 (1H, d), 7.57 (1H, d), 7.34 (1H, s), 7.17 (1H, d), 3.30-3.58 (2H, m), 2.80-3.08 (2H, m), 2.40 (2H, q), 2.33 (3H, s), 1.72-2.18 (4H, m), 1.00-1.20 (4H, m), 0.60 (2H, m), 0.35 (2H, m).