methyl 8-(furan-2-yl)octanoate

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 6.13 g of phosphorous oxychloride were added, while stirring, to 2.93 g of dimethyl formamide at 5°-10° C for 5 minutes. The mixture was kept at 0°-5° C for 40 minutes and then heated to room temperature. Immediately, and with vigorous stirring, 8.96 g of 8-(2-furyl)-octanoic acid methyl ester were added, whereupon the mixture was cooled to 5°-10° C in an ice-salt bath during 1 hour. After further 1 hour at room temperature, 40 g of ice were added, whereupon the mixture was neutralized with 10 g of sodium carbonate. The two phases were then separated, and the aqueous phase was extracted with ether. The combined organic phases were dried and then distilled. Boiling point 144° C at 0.2 mm Hg. was cooled to 5°-10° C in an ice-salt bath during 1 hour After further 1 hour at room temperature The two phases were then separated the aqueous phase was extracted with ether The combined organic phases were dried distilled

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 6.13 g of phosphorous oxychloride were added, while stirring, to 2.93 g of dimethyl formamide at 5°-10° C for 5 minutes. The mixture was kept at 0°-5° C for 40 minutes and then heated to room temperature. Immediately, and with vigorous stirring, 8.96 g of 8-(2-furyl)-octanoic acid methyl ester were added, whereupon the mixture was cooled to 5°-10° C in an ice-salt bath during 1 hour. After further 1 hour at room temperature, 40 g of ice were added, whereupon the mixture was neutralized with 10 g of sodium carbonate. The two phases were then separated, and the aqueous phase was extracted with ether. The combined organic phases were dried and then distilled. Boiling point 144° C at 0.2 mm Hg. was cooled to 5°-10° C in an ice-salt bath during 1 hour After further 1 hour at room temperature The two phases were then separated the aqueous phase was extracted with ether The combined organic phases were dried distilled

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 19 g of 8-(2-furyl)-octanoic acid were refluxed for 4 hours with 100 ml of methanol and 1.5 ml of sulphuric acid. The mixture was then evaporated to one third of its original volume. 100 g. of ice-water were then added, whereupon the mixture was extracted with ether. The mixture was then evaporated to one third of its original volume of ice-water were then added, whereupon the mixture was extracted with ether

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 6.13 g of phosphorous oxychloride were added, while stirring, to 2.93 g of dimethyl formamide at 5°-10° C for 5 minutes. The mixture was kept at 0°-5° C for 40 minutes and then heated to room temperature. Immediately, and with vigorous stirring, 8.96 g of 8-(2-furyl)-octanoic acid methyl ester were added, whereupon the mixture was cooled to 5°-10° C in an ice-salt bath during 1 hour. After further 1 hour at room temperature, 40 g of ice were added, whereupon the mixture was neutralized with 10 g of sodium carbonate. The two phases were then separated, and the aqueous phase was extracted with ether. The combined organic phases were dried and then distilled. Boiling point 144° C at 0.2 mm Hg. was cooled to 5°-10° C in an ice-salt bath during 1 hour After further 1 hour at room temperature The two phases were then separated the aqueous phase was extracted with ether The combined organic phases were dried distilled

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 19 g of 8-(2-furyl)-octanoic acid were refluxed for 4 hours with 100 ml of methanol and 1.5 ml of sulphuric acid. The mixture was then evaporated to one third of its original volume. 100 g. of ice-water were then added, whereupon the mixture was extracted with ether. The mixture was then evaporated to one third of its original volume of ice-water were then added, whereupon the mixture was extracted with ether