methyl 2-aminocyclohexane-1-carboxylate

反応条件: temp:0.00; pressure:0.00; stir:

反応条件: temp:0.00; pressure:0.00; stir:

反応条件: temp:0.00; pressure:0.00; stir:

反応条件: temp:0.00; pressure:0.00; stir:

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: The title compound was synthesized in analogy to Example 1, using 6-cyclohexyl-pyridine-2-carboxylic acid (Example 7 b) and methyl 2-aminocyclohexane-1-carboxylate (CAN 40015-88-1) as starting materials, MS (EI): m/e=345.2 [M+H]+.

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: The title compound was synthesized in analogy to Example 1, using 6-cyclohexyl-pyridine-2-carboxylic acid (Example 7 b) and methyl 2-aminocyclohexane-1-carboxylate (CAN 40015-88-1) as starting materials, MS (EI): m/e=345.2 [M+H]+.

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: The title compound was synthesized in analogy to Example 1, using 6-cyclohexyl-pyridine-2-carboxylic acid (Example 7 b) and methyl 2-aminocyclohexane-1-carboxylate (CAN 40015-88-1) as starting materials, MS (EI): m/e=345.2 [M+H]+.

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: The title compound was synthesized in analogy to Example 1, using 6-cyclohexyl-pyridine-2-carboxylic acid (Example 7 b) and methyl 2-aminocyclohexane-1-carboxylate (CAN 40015-88-1) as starting materials, MS (EI): m/e=345.2 [M+H]+.

反応条件: temp:0.00; pressure:0.00; stir:

反応条件: temp:0.00; pressure:0.00; stir:

反応条件: temp:0.00; pressure:0.00; stir:

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: As described for example 78, 2-amino-cyclohexanecarboxylic acid-methyl ester, 4-nitrophenyl chloroformate, diisopropyl(ethyl)amine, and 7-chloro-4-(1-piperazinyl)-2-quinolinamine are reacted to afford the product as a light yellow solid. LC-MS: 446 (M++1). 1H NMR (CD3OD) δ 1.20–1.40 (m, 4H), 1.90 (m, 3H), 2.10 (m, 1H), 2.45 (m, 1H), 3.30 (m, 4H), 3.70 (m, 8H), 6.35 (s, 1H), 7.38 (d, 1H), 7.60 (s, 1H), 790 (d, 1H). are reacted