piperazin-1-yl(piperidin-1-yl)methanone

反応条件: temp:0.00; pressure:0.00; stir:

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 2-Methylsulfanyl-5,6,7,8-tetrahydro-3H-quinazolin-4-one (100 mg; 0.51 mmol) and piperazin-1-ylpiperidin-1-ylmethanone (100.5 mg; 0.51 mmol) are reacted in isoamyl alcohol (1 ml) in accordance with the procedure for Example 1. After a reaction time of 4 h, piperazin-1-ylpiperidin-1-ylmethanone (50.3 mg; 0.26 mmol) and isoamyl alcohol (0.5 ml) are again added, and the mixture is again irradiated in the microwave for 4 h. The crystals obtained after conventional work-up are dissolved in acetonitrile and water and freeze-dried; yield: 17 mg (9%), crystals; the mixture is again irradiated in the microwave for 4 h The crystals obtained after conventional work-up water and freeze-dried

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: The title compound was synthesized in analogy to example 1, from 5-(4-isopropyl-piperazine-1-carbonyl)-1H-indole-2-carboxylic acid hydrochloride (example 1, intermediate b) and piperazin-1-yl-piperidin-1-yl-methanone to afford the desired product as a light-brown foam (95%). MS (ISP): 495.5 (M+H)+

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: In like manner, 1-chloro-6,7-diethoxyisoquinoline and 1-(piperidinocarbonyl)piperazine react to afford 1-(4-piperidinocarbonyl-1-piperazinyl)-6,7-diethoxyisoquinoline, while 4-chloro-6,7-dimethoxyquinazoline and 1-(piperidinocarbonyl)piperazine react to afford 4-(4-piperidinocarbonyl-1-piperazinyl)-6,7-dimethoxyquinazoline respectively. The latter compound is, of course, identical in every respect with the product of Example V.

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: In like manner, 1-chloro-6,7-diethoxyisoquinoline and 1-(piperidinocarbonyl)piperazine react to afford 1-(4-piperidinocarbonyl-1-piperazinyl)-6,7-diethoxyisoquinoline, while 4-chloro-6,7-dimethoxyquinazoline and 1-(piperidinocarbonyl)piperazine react to afford 4-(4-piperidinocarbonyl-1-piperazinyl)-6,7-dimethoxyquinazoline respectively. The latter compound is, of course, identical in every respect with the product of Example V.

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 2-Methylsulfanyl-5,6,7,8-tetrahydro-3H-quinazolin-4-one (100 mg; 0.51 mmol) and piperazin-1-ylpiperidin-1-ylmethanone (100.5 mg; 0.51 mmol) are reacted in isoamyl alcohol (1 ml) in accordance with the procedure for Example 1. After a reaction time of 4 h, piperazin-1-ylpiperidin-1-ylmethanone (50.3 mg; 0.26 mmol) and isoamyl alcohol (0.5 ml) are again added, and the mixture is again irradiated in the microwave for 4 h. The crystals obtained after conventional work-up are dissolved in acetonitrile and water and freeze-dried; yield: 17 mg (9%), crystals; the mixture is again irradiated in the microwave for 4 h The crystals obtained after conventional work-up water and freeze-dried