4-[2-(trifluoromethyl)phenyl]butan-2-one

反応条件: temp:0.00; pressure:0.00; stir:

反応条件: temp:0.00; pressure:0.00; stir:

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 1.5 g of 4-(2-trifluoromethylphenyl)butan-2-one, 0.41 g of sodium cyanide and 0.56 g of ammonium chloride are dissolved in 77 ml of a 2M solution of ammonia in ethanol and the mixture is stirred at ambient temperature for 7 h. The mixture is subsequently concentrated under reduced pressure and the residue is redissolved in ethyl acetate and washed with water and three times with saturated sodium chloride solution. The organic phase is separated, dried with magnesium sulfate and evaporated under reduced pressure. After purifying the residue by flash chromatography, the title compound is thus obtained. The mixture is subsequently concentrated under reduced pressure the residue is redissolved in ethyl acetate washed with water and three times with saturated sodium chloride solution The organic phase is separated dried with magnesium sulfate evaporated under reduced pressure After purifying the residue by flash chromatography

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 200 mg of Raney nickel are added to a solution of 2.05 g of 4-(2-trifluoromethylphenyl)-3-buten-2-one in 100 ml of ethyl acetate and the mixture is stirred under a hydrogen atmosphere and at standard pressure for 7 h. The mixture is subsequently filtered and the filtrate is evaporated under reduced pressure, whereby the title compound is obtained. The mixture is subsequently filtered the filtrate is evaporated under reduced pressure, whereby the title compound is obtained

反応条件: temp:0.00; pressure:0.00; stir:

反応条件: temp:0.00; pressure:0.00; stir:

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 1.5 g of 4-(2-trifluoromethylphenyl)butan-2-one, 0.41 g of sodium cyanide and 0.56 g of ammonium chloride are dissolved in 77 ml of a 2M solution of ammonia in ethanol and the mixture is stirred at ambient temperature for 7 h. The mixture is subsequently concentrated under reduced pressure and the residue is redissolved in ethyl acetate and washed with water and three times with saturated sodium chloride solution. The organic phase is separated, dried with magnesium sulfate and evaporated under reduced pressure. After purifying the residue by flash chromatography, the title compound is thus obtained. The mixture is subsequently concentrated under reduced pressure the residue is redissolved in ethyl acetate washed with water and three times with saturated sodium chloride solution The organic phase is separated dried with magnesium sulfate evaporated under reduced pressure After purifying the residue by flash chromatography

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 200 mg of Raney nickel are added to a solution of 2.05 g of 4-(2-trifluoromethylphenyl)-3-buten-2-one in 100 ml of ethyl acetate and the mixture is stirred under a hydrogen atmosphere and at standard pressure for 7 h. The mixture is subsequently filtered and the filtrate is evaporated under reduced pressure, whereby the title compound is obtained. The mixture is subsequently filtered the filtrate is evaporated under reduced pressure, whereby the title compound is obtained

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 1.5 g of 4-(2-trifluoromethylphenyl)butan-2-one, 0.41 g of sodium cyanide and 0.56 g of ammonium chloride are dissolved in 77 ml of a 2M solution of ammonia in ethanol and the mixture is stirred at ambient temperature for 7 h. The mixture is subsequently concentrated under reduced pressure and the residue is redissolved in ethyl acetate and washed with water and three times with saturated sodium chloride solution. The organic phase is separated, dried with magnesium sulfate and evaporated under reduced pressure. After purifying the residue by flash chromatography, the title compound is thus obtained. The mixture is subsequently concentrated under reduced pressure the residue is redissolved in ethyl acetate washed with water and three times with saturated sodium chloride solution The organic phase is separated dried with magnesium sulfate evaporated under reduced pressure After purifying the residue by flash chromatography

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 200 mg of Raney nickel are added to a solution of 2.05 g of 4-(2-trifluoromethylphenyl)-3-buten-2-one in 100 ml of ethyl acetate and the mixture is stirred under a hydrogen atmosphere and at standard pressure for 7 h. The mixture is subsequently filtered and the filtrate is evaporated under reduced pressure, whereby the title compound is obtained. The mixture is subsequently filtered the filtrate is evaporated under reduced pressure, whereby the title compound is obtained