chloro-bis(phenylmethoxy)phosphane

反応条件: temp:25.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A stirred solution of N-amidino-3,5-diamino-6-chloropyrazinamide (4.6 g., 0.02 mole) and DBN (2.5 g., 0.02 mole) in dimethylformamide (150 ml) is treated with dibenzylchlorophosphite (6.6 g., 0.22 mole) in one portion. The reaction mixture is stirred at 25° C. for 18 hours, filtered and treated with water to precipitate dibenzyl N-[3,5-diamino-6-chloro-pyrazinamido)iminomethyl]phosphoramidate which melts at 187° C. filtered treated with water to precipitate dibenzyl N-[3,5-diamino-6-chloro-pyrazinamido)iminomethyl]phosphoramidate which melts at 187° C.

反応条件: temp:25.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A stirred solution of N-amidino-3,5-diamino-6-chloropyrazinamide (4.6 g., 0.02 mole) and DBN (2.5 g., 0.02 mole) in dimethylformamide (150 ml) is treated with dibenzylchlorophosphite (6.6 g., 0.22 mole) in one portion. The reaction mixture is stirred at 25° C. for 18 hours, filtered and treated with water to precipitate dibenzyl N-[3,5-diamino-6-chloro-pyrazinamido)iminomethyl]phosphoramidate which melts at 187° C. filtered treated with water to precipitate dibenzyl N-[3,5-diamino-6-chloro-pyrazinamido)iminomethyl]phosphoramidate which melts at 187° C.

反応条件: temp:25.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A stirred solution of N-amidino-3,5-diamino-6-chloropyrazinamide (4.6 g., 0.02 mole) and DBN (2.5 g., 0.02 mole) in dimethylformamide (150 ml) is treated with dibenzylchlorophosphite (6.6 g., 0.22 mole) in one portion. The reaction mixture is stirred at 25° C. for 18 hours, filtered and treated with water to precipitate dibenzyl N-[3,5-diamino-6-chloro-pyrazinamido)iminomethyl]phosphoramidate which melts at 187° C. filtered treated with water to precipitate dibenzyl N-[3,5-diamino-6-chloro-pyrazinamido)iminomethyl]phosphoramidate which melts at 187° C.

反応条件: temp:25.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A stirred solution of N-amidino-3,5-diamino-6-chloropyrazinamide (4.6 g., 0.02 mole) and DBN (2.5 g., 0.02 mole) in dimethylformamide (150 ml) is treated with dibenzylchlorophosphite (6.6 g., 0.22 mole) in one portion. The reaction mixture is stirred at 25° C. for 18 hours, filtered and treated with water to precipitate dibenzyl N-[3,5-diamino-6-chloro-pyrazinamido)iminomethyl]phosphoramidate which melts at 187° C. filtered treated with water to precipitate dibenzyl N-[3,5-diamino-6-chloro-pyrazinamido)iminomethyl]phosphoramidate which melts at 187° C.