2-bromo-1-(2,4,6-trimethylphenyl)ethanone

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 0.3 mol of 1-(2,4,6-trimethylphenyl)-1-ethanone are dissolved in 200 ml of glacial acetic acid and 31.8 g of bromine are added dropwise, while maintaining the reaction medium at a temperature below 10° C. After the addition, the reaction medium is allowed to return to room temperature and is left at this temperature for 2 hours. The reaction medium is then poured into 500 ml of ice-water and the aqueous phase is extracted with ethyl ether. The organic extracts are washed with saturated aqueous sodium bicarbonate solution and then with salted water, and are dried over anhydrous magnesium sulphate. while maintaining the reaction medium at a temperature below 10° C After the addition to return to room temperature the aqueous phase is extracted with ethyl ether The organic extracts are washed with saturated aqueous sodium bicarbonate solution with salted water, and are dried over anhydrous magnesium sulphate

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 0.3 mol of 1-(2,4,6-trimethylphenyl)-1-ethanone are dissolved in 200 ml of glacial acetic acid and 31.8 g of bromine are added dropwise, while maintaining the reaction medium at a temperature below 10° C. After the addition, the reaction medium is allowed to return to room temperature and is left at this temperature for 2 hours. The reaction medium is then poured into 500 ml of ice-water and the aqueous phase is extracted with ethyl ether. The organic extracts are washed with saturated aqueous sodium bicarbonate solution and then with salted water, and are dried over anhydrous magnesium sulphate. while maintaining the reaction medium at a temperature below 10° C After the addition to return to room temperature the aqueous phase is extracted with ethyl ether The organic extracts are washed with saturated aqueous sodium bicarbonate solution with salted water, and are dried over anhydrous magnesium sulphate

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Dissolve 0.3 mol of 1-(2,4,6-trimethylphenyl)-1-ethanone in 200 ml of glacial acetic acid, and add 31.8 g of bromine dropwise while maintaining the reaction medium at a temperature below 10° C. When the addition is complete, allow the reaction medium to return to room temperature and leave at this temperature for 2 hours. Then pour the reaction medium into 500 ml of ice-cold water and extract the aqueous phase with ethyl ether. Wash the organic extracts with saturated aqueous sodium bicarbonate solution and then with salt water, and dry over anhydrous magnesium sulphate. while maintaining the reaction medium at a temperature below 10° C When the addition to return to room temperature leave at this temperature for 2 hours extract the aqueous phase with ethyl ether Wash the organic extracts with saturated aqueous sodium bicarbonate solution with salt water, and dry over anhydrous magnesium sulphate

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Dissolve 0.3 mol of 1-(2,4,6-trimethylphenyl)-1-ethanone in 200 ml of glacial acetic acid, and add 31.8 g of bromine dropwise while maintaining the reaction medium at a temperature below 10° C. When the addition is complete, allow the reaction medium to return to room temperature and leave at this temperature for 2 hours. Then pour the reaction medium into 500 ml of ice-cold water and extract the aqueous phase with ethyl ether. Wash the organic extracts with saturated aqueous sodium bicarbonate solution and then with salt water, and dry over anhydrous magnesium sulphate. while maintaining the reaction medium at a temperature below 10° C When the addition to return to room temperature leave at this temperature for 2 hours extract the aqueous phase with ethyl ether Wash the organic extracts with saturated aqueous sodium bicarbonate solution with salt water, and dry over anhydrous magnesium sulphate

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 2-Bromo-1-mesitylethanone (2.43 g, 10.1 mmol) and thiourea (0.810 g, 10.6 mmol) were dissolved in 95% ethanol (20 mL). The reaction mixture was heated at reflux for 2.0 h. The solution was concentrated under reduced pressure, and the residue was recrystallized from 2-propanol to give the desired 4-mesitylthiazol-2-amine (2.36 g) as white solids: 1H NMR (500 MHz, CD3OD) δ 7.00 (2 H, s), 6.67 (1 H, s), 2.31 (3 H, s), 2.19 (6 H, s). The reaction mixture was heated at reflux for 2.0 h The solution was concentrated under reduced pressure the residue was recrystallized from 2-propanol

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 2-Bromo-1-mesitylethanone (2.43 g, 10.1 mmol) and thiourea (0.810 g, 10.6 mmol) were dissolved in 95% ethanol (20 mL). The reaction mixture was heated at reflux for 2.0 h. The solution was concentrated under reduced pressure, and the residue was recrystallized from 2-propanol to give the desired 4-mesitylthiazol-2-amine (2.36 g) as white solids: 1H NMR (500 MHz, CD3OD) δ 7.00 (2H, s), 6.67 (1H, s), 2.31 (3H, s), 2.19 (6H, s). The reaction mixture was heated at reflux for 2.0 h The solution was concentrated under reduced pressure the residue was recrystallized from 2-propanol

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 2-Bromo-1-mesitylethanone (2.43 g, 10.1 mmol) and thiourea (0.810 g, 10.6 mmol) were dissolved in 95% ethanol (20 mL). The reaction mixture was heated at reflux for 2.0 h. The solution was concentrated under reduced pressure, and the residue was recrystallized from 2-propanol to give the desired 4-mesitylthiazol-2-amine (2.36 g) as white solids: 1H NMR (500 MHz, CD3OD) δ 7.00 (s, 2 H), 6.67 (s, 1 H), 2.31 (s, 3 H), 2.19 (s, 6 H). The reaction mixture was heated at reflux for 2.0 h The solution was concentrated under reduced pressure the residue was recrystallized from 2-propanol

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 0.3 mol of 1-(2,4,6-trimethylphenyl)-1-ethanone are dissolved in 200 mi of glacial acetic acid and 31.8 g of bromine are added dropwise, while maintaining the reaction medium at a temperature below 10° C. After the addition, the reaction medium is allowed to return to room temperature and is left at this temperature for 2 hours. The reaction medium is then poured into 500 ml of ice-water and the aqueous phase is extracted with ethyl ether. The organic extracts are washed with saturated aqueous sodium bicarbonate solution end then with salted water, end are dried over anhydrous magnesium sulphate. are added dropwise while maintaining the reaction medium at a temperature below 10° C After the addition to return to room temperature the aqueous phase is extracted with ethyl ether The organic extracts are washed with saturated aqueous sodium bicarbonate solution end with salted water, end are dried over anhydrous magnesium sulphate

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 0.3 mol of 1-(2,4,6-trimethylphenyl)-1-ethanone are dissolved in 200 ml of glacial acetic acid and 31.8 g of bromine are added dropwise, while maintaining the reaction medium at a temperature below 10° C. After the addition, the reaction medium is allowed to return to room temperature and is left at this temperature for 2 hours. The reaction medium is then poured into 500 ml of ice-water and the aqueous phase is extracted with ethyl ether. The organic extracts are washed with saturated aqueous sodium bicarbonate solution and then with salted water, and are dried over anhydrous magnesium sulphate. while maintaining the reaction medium at a temperature below 10° C After the addition to return to room temperature the aqueous phase is extracted with ethyl ether The organic extracts are washed with saturated aqueous sodium bicarbonate solution with salted water, and are dried over anhydrous magnesium sulphate

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Dissolve 0.3 mol of 1-(2,4,6-trimethylphenyl)-1-ethanone in 200 ml of glacial acetic acid, and add 31.8 g of bromine dropwise while maintaining the reaction medium at a temperature below 10° C. When the addition is complete, allow the reaction medium to return to room temperature and leave at this temperature for 2 hours. Then pour the reaction medium into 500 ml of ice-cold water and extract the aqueous phase with ethyl ether. Wash the organic extracts with saturated aqueous sodium bicarbonate solution and then with salt water, and dry over anhydrous magnesium sulphate. while maintaining the reaction medium at a temperature below 10° C When the addition to return to room temperature leave at this temperature for 2 hours extract the aqueous phase with ethyl ether Wash the organic extracts with saturated aqueous sodium bicarbonate solution with salt water, and dry over anhydrous magnesium sulphate