1-isothiocyanatohexane

反応条件: temp:0.00; pressure:0.00; stir:

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: The title compound was prepared from 2-amino-4-chlorobenzenesulfonamide and hexyl isothiocyanate by a method analogous to the one described in Example 4; m.p. 244-247° C. (ethyl acetate); 1H-NMR (DMSO-d6): δ 0.88 (distorted t, 3H, CH3), 1.31 (m, 6H, 3×CH2), 1.53 (m, 2H, CH2), 3.22 (q, 2H, NHCH2), 7.2-7.4 (m, 3H, ArH+NH), 7.68 (d, 1H, ArH), 10.55 (br.s, 1H, NH); MS: m/e 315/317 (M+); (C13H18N3Cl1O2S1) caic. C, 49.44; H, 5.74 N, 13.31; found C, 49.59; H, 6.01; N, 13.25.

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: The equipment, procedure and reactants were the same as in Example 31 with the exception that 10.01 g (0.07 mole) of n-hexylisothiocyanate, 8.05 g (0.07 mole) 2-aminoheptane, 35 ml ethanol 2B, 11.7 g (0.075 mole) ethyl iodide, 200 ml of toluene and a one percent solution sodium hydroxide (0.08 mole) were used as reactants and reagents in the procedure. The reaction produced 19.6 g (98 weight percent of theory yield of a clear liquid having a nD30 of 1.4765. The product was identified as the title product by IR and NMR spectra analyses. The reaction produced 19.6 g (98 weight percent of theory yield of a clear liquid

反応条件: temp:0.00; pressure:0.00; stir:

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: The equipment, procedure and reactants were the same as in Example 31 with the exception that 10.01 g (0.07 mole) of n-hexylisothiocyanate, 8.05 g (0.07 mole) 2-aminoheptane, 35 ml ethanol 2B, 11.7 g (0.075 mole) ethyl iodide, 200 ml of toluene and a one percent solution sodium hydroxide (0.08 mole) were used as reactants and reagents in the procedure. The reaction produced 19.6 g (98 weight percent of theory yield of a clear liquid having a nD30 of 1.4765. The product was identified as the title product by IR and NMR spectra analyses. The reaction produced 19.6 g (98 weight percent of theory yield of a clear liquid

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: The title compound was prepared from 3-amino-5-chlorothiophene-2-sulfonamide hydrochloride and n-hexyl isothiocyanate by a procedure analogous to the procedure described in example 3Bc-d; mp 207°-209° C.; 1H-NMR (DMSO-d6): δ 0.87 (distorted t, 3H), 1.28 (m, 6H), 1.51 (m, 2H), 3.17 (q, 2H), 7.05 (s, 1H), 7.30 (br. s, 1H), 11.01 (s, 1H).

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: The title compound was prepared from 2-amino-4-chlorobenzenesulfonamide and hexyl isothiocyanate by a method analogous to the one described in Example 4; m.p. 244-247° C. (ethyl acetate); 1H-NMR (DMSO-d6): δ 0.88 (distorted t, 3H, CH3), 1.31 (m, 6H, 3×CH2), 1.53 (m, 2H, CH2), 3.22 (q, 2H, NHCH2), 7.2-7.4 (m, 3H, ArH+NH), 7.68 (d, 1H, ArH), 10.55 (br.s, 1H, NH); MS: m/e 315/317 (M+); (C13H18N3Cl1O2S1) caic. C, 49.44; H, 5.74 N, 13.31; found C, 49.59; H, 6.01; N, 13.25.

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: The equipment, procedure and reactants were the same as in Example 31 with the exception that 10.01 g (0.07 mole) of n-hexylisothiocyanate, 8.05 g (0.07 mole) 2-aminoheptane, 35 ml ethanol 2B, 11.7 g (0.075 mole) ethyl iodide, 200 ml of toluene and a one percent solution sodium hydroxide (0.08 mole) were used as reactants and reagents in the procedure. The reaction produced 19.6 g (98 weight percent of theory yield of a clear liquid having a nD30 of 1.4765. The product was identified as the title product by IR and NMR spectra analyses. The reaction produced 19.6 g (98 weight percent of theory yield of a clear liquid