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C1=CC=C(C=C1)CSC2=CC=CC=C2CO製品情報
(2-benzylsulfanylphenyl)methanol (CAS 4521-45-3) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
想定用途
専門的研究・工業用途限定
データベース ID 10977293
安全上の注意
For professional research and industrial use only. Review the supplier safety data sheet before handling.
合成データ
12 反応 · 12 文献
反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-1ee100ac243249858ad0e4830b4dd513反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-ca376c481349497394d5088f0c47ed45反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: A solution of (2-Benzylsulfanyl)methanol 4 (120 mg, 0.522 mmol) in anhydrous Et2O was cooled to 4° C. A solution of PBr3 (49 μL, 0.52 mmol) in anhydrous Et2O was added dropwise, keeping the temperature below 10° C. The reaction was allowed to warm to ambient temperature and stirred for one hour. The reaction was filtered through silica gel (2.0 g) and washed with Et2O. The filtrate was washed with H2O saturated aqueous sodium bicarbonate and brine. The organic layer was dried over Na2SO4, filtered and evaporated to give 95 mg of the named product as a yellow oil. the temperature below 10° C The reaction was filtered through silica gel (2.0 g) washed with Et2O The filtrate was washed with H2O saturated aqueous sodium bicarbonate and brine The organic layer was dried over Na2SO4 filtered evaporated
ソース ID: ord-dbf5729baf134b0c85e43e9d83ccc742反応条件: temp:0.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: To a solution of 2-benzylsulfanyl benzoic acid 3 (50 mg, 0.206 mmol) in THF at 0° C. was added LiAlH4 (0.62 mL of a 1.0 mL solution in THF, 0.62 mmol) and the mixture was stirred at 0° C. for 15 minutes then allowed to warm to room temperature. The solution was stirred for 2 hours. The mixture was cooled at 0° C. then methanol (MeOH) was added slowly followed by HCl (0.5N) and tetrahydrofuran (THF). The mixture was stirred at room temperature for 30 minutes. It was then concentrated to remove THF, extracted with CH2Cl2 (3×), dried over MgSO4, filtered and concentrated to give 30 mg of the product as a yellow oil. to warm to room temperature The solution was stirred for 2 hours The mixture was cooled at 0° C. The mixture was stirred at room temperature for 30 minutes It was then concentrated to remove THF extracted with CH2Cl2 (3×) dried over MgSO4 filtered concentrated
ソース ID: ord-7ac90b6a9f3b444691e04f82f4805811反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: A solution of (2-Benzylsulfanyl)methanol 4 (120 mg, 0.522 mmol) in anhydrous Et2O was cooled to 4° C. A solution of PBr3 (49 μL, 0.52 mmol) in anhydrous Et2O was added dropwise, keeping the temperature below 10° C. The reaction was allowed to warm to ambient temperature and stirred for one hour. The reaction was filtered through silica gel (2.0 g) and washed with Et2O. The filtrate was washed with H2O saturated aqueous sodium bicarbonate and brine. The organic layer was dried over Na2SO4, filtered and evaporated to give 95 mg of the named product as a yellow oil. the temperature below 10° C The reaction was filtered through silica gel (2.0 g) washed with Et2O The filtrate was washed with H2O saturated aqueous sodium bicarbonate and brine The organic layer was dried over Na2SO4 filtered evaporated
ソース ID: ord-dae2fd9bf2a242829a417f449efb103f反応条件: temp:0.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: To a solution of 2-benzylsulfanyl benzoic acid 3 (50 mg, 0.206 mmol) in THF at 0° C. was added LiAlH4 (0.62 mL of a 1.0 mL solution in THF, 0.62 mmol) and the mixture was stirred at 0° C. for 15 minutes then allowed to warm to room temperature. The solution was stirred for 2 hours. The mixture was cooled at 0° C. then methanol (MeOH) was added slowly followed by HCl (0.5N) and tetrahydrofuran (THF). The mixture was stirred at room temperature for 30 minutes. It was then concentrated to remove THF, extracted with CH2Cl2 (3X), dried over MgSO4, filtered and concentrated to give 30 mg of the product as a yellow oil. to warm to room temperature The solution was stirred for 2 hours The mixture was cooled at 0° C. The mixture was stirred at room temperature for 30 minutes It was then concentrated to remove THF extracted with CH2Cl2 (3X) dried over MgSO4 filtered concentrated
ソース ID: ord-63615ad3fdcf46798ec103c948af08a5反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-1ee100ac243249858ad0e4830b4dd513反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: A solution of (2-Benzylsulfanyl)methanol 4 (120 mg, 0.522 mmol) in anhydrous Et2O was cooled to 4° C. A solution of PBr3 (49 μL, 0.52 mmol) in anhydrous Et2O was added dropwise, keeping the temperature below 10° C. The reaction was allowed to warm to ambient temperature and stirred for one hour. The reaction was filtered through silica gel (2.0 g) and washed with Et2O. The filtrate was washed with H2O saturated aqueous sodium bicarbonate and brine. The organic layer was dried over Na2SO4, filtered and evaporated to give 95 mg of the named product as a yellow oil. the temperature below 10° C The reaction was filtered through silica gel (2.0 g) washed with Et2O The filtrate was washed with H2O saturated aqueous sodium bicarbonate and brine The organic layer was dried over Na2SO4 filtered evaporated
ソース ID: ord-dae2fd9bf2a242829a417f449efb103f反応条件: temp:0.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: To a solution of 2-benzylsulfanyl benzoic acid 3 (50 mg, 0.206 mmol) in THF at 0° C. was added LiAlH4 (0.62 mL of a 1.0 mL solution in THF, 0.62 mmol) and the mixture was stirred at 0° C. for 15 minutes then allowed to warm to room temperature. The solution was stirred for 2 hours. The mixture was cooled at 0° C. then methanol (MeOH) was added slowly followed by HCl (0.5N) and tetrahydrofuran (THF). The mixture was stirred at room temperature for 30 minutes. It was then concentrated to remove THF, extracted with CH2Cl2 (3X), dried over MgSO4, filtered and concentrated to give 30 mg of the product as a yellow oil. to warm to room temperature The solution was stirred for 2 hours The mixture was cooled at 0° C. The mixture was stirred at room temperature for 30 minutes It was then concentrated to remove THF extracted with CH2Cl2 (3X) dried over MgSO4 filtered concentrated
ソース ID: ord-63615ad3fdcf46798ec103c948af08a5反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-ca376c481349497394d5088f0c47ed45反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: A solution of (2-Benzylsulfanyl) methanol 4 (120 mg, 0.522 mmol) in anhydrous Et2O was cooled to 4° C. A solution of PBr3 (49 μL, 0.52 mmol) in anhydrous Et2O was added dropwise, keeping the temperature below 10° C. The reaction was allowed to warm to ambient temperature and stirred for one hour. The reaction was filtered through silica gel (2.0 g) and washed with Et2O. The filtrate was washed with H2O saturated aqueous sodium bicarbonate and brine. The organic layer was dried over Na2SO4, filtered and evaporated to give 95 mg of the named product as a yellow oil. the temperature below 10° C The reaction was filtered through silica gel (2.0 g) washed with Et2O The filtrate was washed with H2O saturated aqueous sodium bicarbonate and brine The organic layer was dried over Na2SO4 filtered evaporated
ソース ID: ord-41ca3d8adcca4d3899a3b8500b8ba9a3反応条件: temp:0.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: To a solution of 2-benzylsulfanyl benzoic acid 3 (50 mg, 0.206 mmol) in THF at 0° C. was added LiAlH4 (0.62 mL of a 1.0 mL solution in THF, 0.62 mmol) and the mixture was stirred at 0° C. for 15 minutes then allowed to warm to room temperature. The solution was stirred for 2 hours. The mixture was cooled at 0° C. then methanol (MeOH) was added slowly followed by HCl (0.5N) and tetrahydrofuran (THF). The mixture was stirred at room temperature for 30 minutes. It was then concentrated to remove THF, extracted with CH2Cl2 (3×), dried over MgSO4, filtered and concentrated to give 30 mg of the product as a yellow oil. to warm to room temperature The solution was stirred for 2 hours The mixture was cooled at 0° C. The mixture was stirred at room temperature for 30 minutes It was then concentrated to remove THF extracted with CH2Cl2 (3×) dried over MgSO4 filtered concentrated
ソース ID: ord-fe37c756670548ceb212b8675ce6b38dPubChem References
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