3-Fluoro-1,2-propanediol

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: As another example, 2-fluoromethyl-1,1,4,4-tetrafluorobutane may be prepared by oxidizing commercially available 3-fluoro-1,2-propanediol to form a product which may then be reacted with CF2 carbene to form 2-fluoromethyl-1,1,4,4-tetrafluoro-1,3-butadiene which may then be hydrogenated to form 2-fluoromethyl-1,1,4,4-tetrafluorobutane. to form a product which

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: As another example, 2-fluoromethyl-1,1,4,4-tetrafluorobutane may be prepared by oxidizing commercially available 3-fluoro-1,2-propanediol to form a product which may then be reacted with CF2 carbene to form 2-fluoromethyl-1,1,4,4-tetrafluoro-1,3-butadiene which may then be hydrogenated to form 2-fluoromethyl-1,1,4,4-tetrafluorobutane. to form a product which

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: As another example, 2-methyl-1,1,3-trifluoropropane may be prepared by reacting commercially available fluoroacetone with a CF2 carbene to form 2-fluoromethyl-1,1-difluoro-1-propene which may then be hydrogenated to form 2-methyl-1,1,3-trifluoropropane. As another example, 2-fluoromethyl-1,1,4,4-tetrafluorobutane may be prepared by oxidizing commercially available 3-fluoro-1,2-propanediol to form a product which may then be reacted with a CF2 carbene to form 2-fluoromethyl-1,1,4,4-tetrafluoro-1,3-butadiene; the 2-fluoromethyl-1,1,4,4-tetrafluoro-1,3-butadiene may then be hydrogenated to form 2-fluoromethyl-1,1,4,4-tetrafluorobutane. to form a product which

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: As another example, 2-methyl-1,1,3-trifluoropropane may be prepared by reacting commercially available fluoroacetone with a CF2 carbene to form 2-fluoromethyl-1,1-difluoro-1-propene which may then be hydrogenated to form 2-methyl-1,1,3-trifluoropropane. As another example, 2-fluoromethyl-1,1,4,4-tetrafluorobutane may be prepared by oxidizing commercially available 3-fluoro-1,2-propanediol to form a product which may then be reacted with a CF2 carbene to form 2-fluoromethyl-1,1,4,4-tetrafluoro-1,3-butadiene; the 2-fluoromethyl-1,1,4,4-tetrafluoro-1,3-butadiene may then be hydrogenated to form 2-fluoromethyl-1,1,4,4-tetrafluorobutane. to form a product which

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: As another example, 2-fluoromethyl-1,1,4,4-tetrafluorobutane may be prepared by oxidizing commercially available 3-fluoro-1,2-propanediol to form a product which may then be reacted with CF2 carbene to form 2-fluoromethyl-1,1,4,4-tetrafluoro-1,3-butadiene which may then be hydrogenated to form 2-fluoromethyl-1,1,4,4-tetrafluorobutane. to form a product which

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: To a mixture of 3-fluoropropane-1,2-diol (from Sigma, 0.750 g, 7.97 mmol) and triethylamine (1.39 mL, 9.96 mmol) in DCM (20 mL) was added p-toluenesulfonyl chloride (1.60 g, 8.37 mmol). The reaction was stirred at RT for 2 h. The mixture was concentrated to dryness and used in next step. The mixture was concentrated to dryness

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: As another example, 2-fluoromethyl-1,1,4,4-tetrafluorobutane may be prepared by oxidizing commercially available 3-fluoro-1,2-propanediol to form a product which may then be reacted with CF2 carbene to form 2-fluoromethyl-1,1,4,4-tetrafluoro-1,3-butadiene which may then be hydrogenated to form 2-fluoromethyl-1,1,4,4-tetrafluorobutane. to form a product which

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: As another example, 2-methyl-1,1,3-trifluoropropane may be prepared by reacting commercially available fluoroacetone with a CF2 carbene to form 2-fluoromethyl-1,1-difluoro-1-propene which may then be hydrogenated to form 2-methyl-1,1,3-trifluoropropane. As another example, 2-fluoromethyl-1,1,4,4-tetrafluorobutane may be prepared by oxidizing commercially available 3-fluoro-1,2-propanediol to form a product which may then be reacted with a CF2 carbene to form 2-fluoromethyl-1,1,4,4-tetrafluoro-1,3-butadiene; the 2-fluoromethyl-1,1,4,4-tetrafluoro-1,3-butadiene may then be hydrogenated to form 2-fluoromethyl-1,1,4,4-tetrafluorobutane. to form a product which

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: As another example, 2-fluoromethyl-1,1,4,4-tetrafluorobutane may be prepared by oxidizing commercially available 3-fluoro-1,2-propanediol to form a product which may then be reacted with CF2 carbene to form 2-fluoromethyl-1,1,4,4-tetrafluoro-1,3-butadiene which may then be hydrogenated to form 2-fluoromethyl-1,1,4,4-tetrafluorobutane. to form a product which