N-[(4-chlorophenyl)methyl]butan-2-amine

反応条件: temp:0.00; pressure:0.00; stir:

反応条件: temp:0.00; pressure:0.00; stir:

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 20 g of N-(4-chlorobenzyl)-N-sec.-butylamine were dissolved in 500 ml of ether. To the resulting solution, a solution of 14 g of phenyl isothiocyanate in 50 ml of ether was added dropwise, under cooling and stirring. After the dropwise addition, the temperature of the solution was gradually raised, and the solution was then stirred at room temperature for about 10 hours. The crystals which had been formed were separated by filtration. After recrystallization with a solvent mixture of hexane and ethyl alcohol, 30 g of N-(4-chlorobenzyl)-N-sec.-butyl-N'-phenylthiourea were obtained. Yield: 91%. Melting point: 134°-134.5° C. under cooling After the dropwise addition the temperature of the solution was gradually raised the solution was then stirred at room temperature for about 10 hours The crystals which had been formed were separated by filtration After recrystallization with a solvent mixture of hexane and ethyl alcohol

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 20 g of N-(4-chlorobenzyl)-N-sec.-butylamine were dissolved in 500 ml of ether. To the resulting solution, a solution of 14 g of phenyl isothiocyanate in 50 ml of ether was added dropwise, under cooling and stirring. After the dropwise addition, the temperature of the solution was gradually raised, and the solution was then stirred at room temperature for about 10 hours. The crystals which had been formed were separated by filtration. After recrystallization with a solvent mixture of hexane and ethyl alcohol, 30 g of N-(4-chlorobenzyl)-N-sec.-butyl-N'-phenylthiourea were obtained. Yield: 91%. Melting point: 134°-134.5° C. under cooling After the dropwise addition the temperature of the solution was gradually raised the solution was then stirred at room temperature for about 10 hours The crystals which had been formed were separated by filtration After recrystallization with a solvent mixture of hexane and ethyl alcohol

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 30 g (0.15 mole) of N-(4-chlorobenzyl)N-sec.-butylamine were dissolved in 500 ml of ether. To the resulting solution, a solution of 18 g (0.15 mole) of phenyl isocyanate in 50 ml of ether was added dropwise, under cooling and stirring. After the dropwise addition, the temperature of the solution was gradually raised, and the solution was then stirred at room temperature for about 10 hours. The crystals which had been formed were separated by filtration. After recrystallization with a solvent mixture of hexane and ethyl alcohol, 44 g of N-(4-chlorobenzyl)-N-sec.-butyl-N'-phenylurea were obtained. Yield: 93%. Melting point: 80°-81.5° C. under cooling After the dropwise addition the temperature of the solution was gradually raised the solution was then stirred at room temperature for about 10 hours The crystals which had been formed were separated by filtration After recrystallization with a solvent mixture of hexane and ethyl alcohol

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 30 g (0.15 mole) of N-(4-chlorobenzyl)N-sec.-butylamine were dissolved in 500 ml of ether. To the resulting solution, a solution of 18 g (0.15 mole) of phenyl isocyanate in 50 ml of ether was added dropwise, under cooling and stirring. After the dropwise addition, the temperature of the solution was gradually raised, and the solution was then stirred at room temperature for about 10 hours. The crystals which had been formed were separated by filtration. After recrystallization with a solvent mixture of hexane and ethyl alcohol, 44 g of N-(4-chlorobenzyl)-N-sec.-butyl-N'-phenylurea were obtained. Yield: 93%. Melting point: 80°-81.5° C. under cooling After the dropwise addition the temperature of the solution was gradually raised the solution was then stirred at room temperature for about 10 hours The crystals which had been formed were separated by filtration After recrystallization with a solvent mixture of hexane and ethyl alcohol

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 20 g of N-(4-chlorobenzyl)-N-sec.-butylamine were dissolved in 500 ml of ether. To the resulting solution, a solution of 14 g of phenyl isothiocyanate in 50 ml of ether was added dropwise, under cooling and stirring. After the dropwise addition, the temperature of the solution was gradually raised, and the solution was then stirred at room temperature for about 10 hours. The crystals which had been formed were separated by filtration. After recrystallization with a solvent mixture of hexane and ethyl alcohol, 30 g of N-(4-chlorobenzyl)-N-sec.-butyl-N'-phenylthiourea were obtained. Yield: 91%. Melting point: 134°-134.5° C. under cooling After the dropwise addition the temperature of the solution was gradually raised the solution was then stirred at room temperature for about 10 hours The crystals which had been formed were separated by filtration After recrystallization with a solvent mixture of hexane and ethyl alcohol

反応条件: temp:0.00; pressure:0.00; stir:

反応条件: temp:0.00; pressure:0.00; stir:

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 30 g (0.15 mole) of N-(4-chlorobenzyl)N-sec.-butylamine were dissolved in 500 ml of ether. To the resulting solution, a solution of 18 g (0.15 mole) of phenyl isocyanate in 50 ml of ether was added dropwise, under cooling and stirring. After the dropwise addition, the temperature of the solution was gradually raised, and the solution was then stirred at room temperature for about 10 hours. The crystals which had been formed were separated by filtration. After recrystallization with a solvent mixture of hexane and ethyl alcohol, 44 g of N-(4-chlorobenzyl)-N-sec.-butyl-N'-phenylurea were obtained. Yield: 93%. Melting point: 80°-81.5° C. under cooling After the dropwise addition the temperature of the solution was gradually raised the solution was then stirred at room temperature for about 10 hours The crystals which had been formed were separated by filtration After recrystallization with a solvent mixture of hexane and ethyl alcohol

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 20 g of N-(4-chlorobenzyl)-N-sec.-butylamine were dissolved in 500 ml of ether. To the resulting solution, a solution of 14 g of phenyl isothiocyanate in 50 ml of ether was added dropwise, under cooling and stirring. After the dropwise addition, the temperature of the solution was gradually raised, and the solution was then stirred at room temperature for about 10 hours. The crystals which had been formed were separated by filtration. After recrystallization with a solvent mixture of hexane and ethyl alcohol, 30 g of N-(4-chlorobenzyl)-N-sec.-butyl-N'-phenylthiourea were obtained. Yield: 91%. Melting point: 134°-134.5° C. under cooling After the dropwise addition the temperature of the solution was gradually raised the solution was then stirred at room temperature for about 10 hours The crystals which had been formed were separated by filtration After recrystallization with a solvent mixture of hexane and ethyl alcohol

反応条件: temp:0.00; pressure:0.00; stir: