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C1CCC(CC1)(CN)N製品情報
1-(aminomethyl)cyclohexan-1-amine (CAS 5062-67-9) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
想定用途
専門的研究・工業用途限定
データベース ID 21150
安全上の注意
For professional research and industrial use only. Review the supplier safety data sheet before handling.
合成データ
6 反応 · 6 文献
反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-9356846964eb4c36bb1dd15bd3546d76反応条件: temp:180.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: A mixture of 5-chloro-6-ethyl-3-{[3-(methylsulfonyl)phenyl]amino}pyrazine-2-carboxamide (Preparation Example 353) (150 mg), 1-(aminomethyl)cyclohexaneamine (163 mg) and NMP (1 mL) was heated at 180° C. for 20 minutes using a microwave reaction system. The reaction liquid was cooled, and ethyl acetate and water were added and stirred for 30 minutes. Thereafter, the precipitated powder was collected by filtration. This powder was heated with ethanol-water (1:1) and washed to give 5-{[(1-aminocyclohexyl)methyl]amino}-6-ethyl-3-{[3-(methylsulfonyl)phenyl]amino}pyrazine-2-carboxamide (112 mg) as a white solid. a microwave reaction system The reaction liquid was cooled Thereafter, the precipitated powder was collected by filtration This powder was heated with ethanol-water (1:1) washed
ソース ID: ord-c13fa5b3628040a1ac1bebae7bb831a6反応条件: temp:80.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: A mixture of 4-{[3-(methylcarbamoyl)phenyl]amino}-2-(methylsulfinyl)-6-oxo-1,6-dihydropyrimidine-5-carboxamide (Preparation Example 311) (234 mg), 1-(aminomethyl)cyclohexaneamine (172 mg) and NMP (2 mL) was stirred at 80° C. for 30 minutes. After cooling, the reaction liquid was diluted with ethyl acetate, and the precipitated solid was collected by filtration. This solid was heated with ethanol-water and washed to give 2-{[(1-aminocyclohexyl)methyl]amino}-4-{[3-(methylcarbamoyl)phenyl]amino}-6-oxo-1,6-dihydropyrimidine-5-carboxamide (215 mg) as a white solid. After cooling the reaction liquid the precipitated solid was collected by filtration This solid was heated with ethanol-water washed
ソース ID: ord-bbfc9d00c43c45e39b88ead7400fd8b8反応条件: temp:80.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: A mixture of 4-{[3-(methylcarbamoyl)phenyl]amino}-2-(methylsulfinyl)-6-oxo-1,6-dihydropyrimidine-5-carboxamide (Preparation Example 311) (234 mg), 1-(aminomethyl)cyclohexaneamine (172 mg) and NMP (2 mL) was stirred at 80° C. for 30 minutes. After cooling, the reaction liquid was diluted with ethyl acetate, and the precipitated solid was collected by filtration. This solid was heated with ethanol-water and washed to give 2-{[(1-aminocyclohexyl)methyl]amino}-4-{[3-(methylcarbamoyl)phenyl]amino}-6-oxo-1,6-dihydropyrimidine-5-carboxamide (215 mg) as a white solid. After cooling the reaction liquid the precipitated solid was collected by filtration This solid was heated with ethanol-water washed
ソース ID: ord-bbfc9d00c43c45e39b88ead7400fd8b8反応条件: temp:180.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: A mixture of 5-chloro-6-ethyl-3-{[3-(methylsulfonyl)phenyl]amino}pyrazine-2-carboxamide (Preparation Example 353) (150 mg), 1-(aminomethyl)cyclohexaneamine (163 mg) and NMP (1 mL) was heated at 180° C. for 20 minutes using a microwave reaction system. The reaction liquid was cooled, and ethyl acetate and water were added and stirred for 30 minutes. Thereafter, the precipitated powder was collected by filtration. This powder was heated with ethanol-water (1:1) and washed to give 5-{[(1-aminocyclohexyl)methyl]amino}-6-ethyl-3-{[3-(methylsulfonyl)phenyl]amino}pyrazine-2-carboxamide (112 mg) as a white solid. a microwave reaction system The reaction liquid was cooled Thereafter, the precipitated powder was collected by filtration This powder was heated with ethanol-water (1:1) washed
ソース ID: ord-c13fa5b3628040a1ac1bebae7bb831a6反応条件: temp:80.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: A mixture of 4-{[3-(methylcarbamoyl)phenyl]amino}-2-(methylsulfinyl)-6-oxo-1,6-dihydropyrimidine-5-carboxamide (Preparation Example 311) (234 mg), 1-(aminomethyl)cyclohexaneamine (172 mg) and NMP (2 mL) was stirred at 80° C. for 30 minutes. After cooling, the reaction liquid was diluted with ethyl acetate, and the precipitated solid was collected by filtration. This solid was heated with ethanol-water and washed to give 2-{[(1-aminocyclohexyl)methyl]amino}-4-{[3-(methylcarbamoyl)phenyl]amino}-6-oxo-1,6-dihydropyrimidine-5-carboxamide (215 mg) as a white solid. After cooling the reaction liquid the precipitated solid was collected by filtration This solid was heated with ethanol-water washed
ソース ID: ord-bbfc9d00c43c45e39b88ead7400fd8b8PubChem References
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