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C1=CC(=C(C(=C1)O)Cl)C#N製品情報
2-chloro-3-hydroxybenzonitrile (CAS 51786-11-9) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
想定用途
専門的研究・工業用途限定
データベース ID 21436545
安全上の注意
For professional research and industrial use only. Review the supplier safety data sheet before handling.
合成データ
12 反応 · 12 文献
反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-9d93bd9072ae42479a1b43abd088275b反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: A mixture of 2-chloro-3-hydroxybenzaldehyde [(2 g, 12.8 mmol) WO 2005007633, p 34] and hydroxyl ammonium chloride (1.33 g, 19.6 mmol) in acetic acid (20 mL) was heated under reflux for 2 hours. The reaction mixture was then cooled to room temperature and partitioned between diethyl ether and water. The organic layer was separated, washed with brine, dried over magnesium sulfate and concentrated in vacuo to give a white solid. The solid was then dissolved in ethyl acetate washed with water and brine, dried over magnesium sulfate and concentrated in vacuo to afford the title compound as a solid in quantitative yield. 1H NMR (400 MHz, CD3OD) δ: 7.18 (d, 1H), 7.26 (m, 2H) was heated under reflux for 2 hours partitioned between diethyl ether and water The organic layer was separated washed with brine dried over magnesium sulfate concentrated in vacuo to give a white solid washed with water and brine dried over magnesium sulfate concentrated in vacuo
ソース ID: ord-14087eda22ef41ffbdd22b6150a09fdc反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: A mixture of 2-chloro-3-hydroxybenzaldehyde [(2 g, 12.8 mmol) WO 2005007633, p 34] and hydroxyl ammonium chloride (1.33 g, 19.6 mmol) in acetic acid (20 mL) was heated under reflux for 2 hours. The reaction mixture was then cooled to room temperature and partitioned between diethyl ether and water. The organic layer was separated, washed with brine, dried over magnesium sulfate and concentrated in vacuo to give a white solid. The solid was then dissolved in ethyl acetate washed with water and brine, dried over magnesium sulfate and concentrated in vacuo to afford the title compound as a solid in quantitative yield. 1H NMR (400 MHz, CD3OD) δ: 7.18 (d, 1H), 7.26 (m, 2H) was heated under reflux for 2 hours partitioned between diethyl ether and water The organic layer was separated washed with brine dried over magnesium sulfate concentrated in vacuo to give a white solid washed with water and brine dried over magnesium sulfate concentrated in vacuo
ソース ID: ord-14087eda22ef41ffbdd22b6150a09fdc反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: A mixture of 2-chloro-3-hydroxybenzaldehyde [(2 g, 12.8 mmol) WO 2005007633, p34] and hydroxyl ammonium chloride (1.33 g, 19.6 mmol) in acetic acid (20 mL) was heated under reflux for 2 hours. The reaction mixture was then cooled to room temperature and partitioned between diethyl ether and water. The organic layer was separated, washed with brine, dried over magnesium sulfate and concentrated in vacuo to give a white solid. The solid was then dissolved in ethyl acetate washed with water and brine, dried over magnesium sulfate and concentrated in vacuo to afford the title compound as a solid in quantitative yield. under reflux for 2 hours partitioned between diethyl ether and water The organic layer was separated washed with brine dried over magnesium sulfate concentrated in vacuo to give a white solid washed with water and brine dried over magnesium sulfate concentrated in vacuo
ソース ID: ord-21425dcc9c6e475983e596b6a620121d反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: A mixture of 2-chloro-3-hydroxybenzaldehyde [(2 g, 12.8 mmol) WO 2005007633, p34] and hydroxyl ammonium chloride (1.33 g, 19.6 mmol) in acetic acid (20 mL) was heated under reflux for 2 hours. The reaction mixture was then cooled to room temperature and partitioned between diethyl ether and water. The organic layer was separated, washed with brine, dried over magnesium sulfate and concentrated in vacuo to give a white solid. The solid was then dissolved in ethyl acetate washed with water and brine, dried over magnesium sulfate and concentrated in vacuo to afford the title compound as a solid in quantitative yield. under reflux for 2 hours partitioned between diethyl ether and water The organic layer was separated washed with brine dried over magnesium sulfate concentrated in vacuo to give a white solid washed with water and brine dried over magnesium sulfate concentrated in vacuo
ソース ID: ord-21425dcc9c6e475983e596b6a620121d反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: A mixture of 2-chloro-3-hydroxybenzaldehyde [(2 g, 12.8 mmol) WO 2005007633, p34] and hydroxyl ammonium chloride (1.33 g, 19.6 mmol) in acetic acid (20 mL) was heated under reflux for 2 hours. The reaction mixture was then cooled to room temperature and partitioned between diethyl ether and water. The organic layer was separated, washed with brine, dried over magnesium sulfate and concentrated in vacuo to give a white solid. The solid was then dissolved in ethyl acetate washed with water and brine, dried over magnesium sulfate and concentrated in vacuo to afford the title compound as a solid in quantitative yield. under reflux for 2 hours partitioned between diethyl ether and water The organic layer was separated washed with brine dried over magnesium sulfate concentrated in vacuo to give a white solid washed with water and brine dried over magnesium sulfate concentrated in vacuo
ソース ID: ord-ada5673d3bfe4b2b954acd2604a1bd63反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: A mixture of 2-chloro-3-hydroxybenzaldehyde [(2 g, 12.8 mmol) WO 2005007633, p 34] and hydroxylammonium chloride (1.33 g, 19.6 mmol) in acetic acid (20 mL) was heated under reflux for 2 hours. The reaction mixture was then cooled to room temperature and partitioned between diethyl ether and water. The organic layer was separated, washed with brine, dried over magnesium sulfate and concentrated in vacuo to give a white solid. The solid was then dissolved in ethyl acetate washed with water and brine, dried over magnesium sulfate and concentrated in vacuo to afford the title compound as a solid in quantitative yield. was heated under reflux for 2 hours partitioned between diethyl ether and water The organic layer was separated washed with brine dried over magnesium sulfate concentrated in vacuo to give a white solid washed with water and brine dried over magnesium sulfate concentrated in vacuo
ソース ID: ord-3228a409c4a9446ebecc30f3b3fc2962反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: A mixture of 2-chloro-3-hydroxybenzaldehyde [(2 g, 12.8 mmol) WO 2005007633, p34] and hydroxyl ammonium chloride (1.33 g, 19.6 mmol) in acetic acid (20 mL) was heated under reflux for 2 hours. The reaction mixture was then cooled to room temperature and partitioned between diethyl ether and water. The organic layer was separated, washed with brine, dried over magnesium sulfate and concentrated in vacuo to give a white solid. The solid was then dissolved in ethyl acetate washed with water and brine, dried over magnesium sulfate and concentrated in vacuo to afford the title compound as a solid in quantitative yield. under reflux for 2 hours partitioned between diethyl ether and water The organic layer was separated washed with brine dried over magnesium sulfate concentrated in vacuo to give a white solid washed with water and brine dried over magnesium sulfate concentrated in vacuo
ソース ID: ord-ada5673d3bfe4b2b954acd2604a1bd63反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: A mixture of 2-chloro-3-hydroxybenzaldehyde [(2 g, 12.8 mmol) WO 2005007633, p 34] and hydroxylammonium chloride (1.33 g, 19.6 mmol) in acetic acid (20 mL) was heated under reflux for 2 hours. The reaction mixture was then cooled to room temperature and partitioned between diethyl ether and water. The organic layer was separated, washed with brine, dried over magnesium sulfate and concentrated in vacuo to give a white solid. The solid was then dissolved in ethyl acetate washed with water and brine, dried over magnesium sulfate and concentrated in vacuo to afford the title compound as a solid in quantitative yield. was heated under reflux for 2 hours partitioned between diethyl ether and water The organic layer was separated washed with brine dried over magnesium sulfate concentrated in vacuo to give a white solid washed with water and brine dried over magnesium sulfate concentrated in vacuo
ソース ID: ord-3228a409c4a9446ebecc30f3b3fc2962反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-9d93bd9072ae42479a1b43abd088275b反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: A mixture of 2-chloro-3-hydroxybenzaldehyde [(2 g, 12.8 mmol) WO 2005007633, p 34] and hydroxyl ammonium chloride (1.33 g, 19.6 mmol) in acetic acid (20 mL) was heated under reflux for 2 hours. The reaction mixture was then cooled to room temperature and partitioned between diethyl ether and water. The organic layer was separated, washed with brine, dried over magnesium sulfate and concentrated in vacuo to give a white solid. The solid was then dissolved in ethyl acetate washed with water and brine, dried over magnesium sulfate and concentrated in vacuo to afford the title compound as a solid in quantitative yield. 1H NMR (400 MHz, CD3OD) δ: 7.18 (d, 1H), 7.26 (m, 2H) was heated under reflux for 2 hours partitioned between diethyl ether and water The organic layer was separated washed with brine dried over magnesium sulfate concentrated in vacuo to give a white solid washed with water and brine dried over magnesium sulfate concentrated in vacuo
ソース ID: ord-14087eda22ef41ffbdd22b6150a09fdc反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: A mixture of 2-chloro-3-hydroxybenzaldehyde [(2 g, 12.8 mmol) WO 2005007633, p34] and hydroxyl ammonium chloride (1.33 g, 19.6 mmol) in acetic acid (20 mL) was heated under reflux for 2 hours. The reaction mixture was then cooled to room temperature and partitioned between diethyl ether and water. The organic layer was separated, washed with brine, dried over magnesium sulfate and concentrated in vacuo to give a white solid. The solid was then dissolved in ethyl acetate washed with water and brine, dried over magnesium sulfate and concentrated in vacuo to afford the title compound as a solid in quantitative yield. under reflux for 2 hours partitioned between diethyl ether and water The organic layer was separated washed with brine dried over magnesium sulfate concentrated in vacuo to give a white solid washed with water and brine dried over magnesium sulfate concentrated in vacuo
ソース ID: ord-21425dcc9c6e475983e596b6a620121dPubChem References
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