2,2,2-trifluoro-N-(1,1,1,3,3,3-hexafluoropropan-2-ylidene)acetamide

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 3-Trifluoromethylbenzonitrile (5.8 g, 3.39 mmol) and 2,2,2-trifluoro-N-{2,2,2-trifluoro-1-(trifluoromethyl) ethylidene}acetamide (1.8 g, 6.90 mmol) were dissolved in dichloromethane (3 mL) and stirred in a sealed vial at room temperature for three days. The solvent and excess reagent were distilled off to give a colorless oil that was chromatographed on silica gel using 5 percent ethyl acetate/hexanes as eluent. The desired product was present as an oil (0.92 g, 63 percent yield) in the first eluted fraction. EIMS (m/z): 432 (M+), 413 (M−F), 363 (M-CF3). The solvent and excess reagent were distilled off to give a colorless oil that was chromatographed on silica gel using 5 percent ethyl acetate/hexanes as eluent

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 3-Trifluoromethylbenzonitrile (5.8 g, 3.39 mmol) and 2,2,2-trifluoro-N-{2,2,2-trifluoro-1-(trifluoromethyl) ethylidene}acetamide (1.8 g, 6.90 mmol) were dissolved in dichloromethane (3 mL) and stirred in a sealed vial at room temperature for three days. The solvent and excess reagent were distilled off to give a colorless oil that was chromatographed on silica gel using 5 percent ethyl acetate/hexanes as eluent. The desired product was present as an oil (0.92 g, 63 percent yield) in the first eluted fraction. EIMS (m/z): 432 (M+), 413 (M−F), 363 (M-CF3). The solvent and excess reagent were distilled off to give a colorless oil that was chromatographed on silica gel using 5 percent ethyl acetate/hexanes as eluent

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 3-Trifluoromethylbenzonitrile (5.8 g, 3.39 mmol) and 2,2,2-trifluoro-N-{2,2,2-trifluoro-1-(trifluoromethyl) ethylidene}acetamide (1.8 g, 6.90 mmol) were dissolved in dichloromethane (3 mL) and stirred in a sealed vial at room temperature for three days. The solvent and excess reagent were distilled off to give a colorless oil that was chromatographed on silica gel using 5 percent ethyl acetate/hexanes as eluent. The desired product was present as an oil (0.92 g, 63 percent yield) in the first eluted fraction. EIMS (m/z): 432 (M+), 413 (M−F), 363 (M-CF3). The solvent and excess reagent were distilled off to give a colorless oil that was chromatographed on silica gel using 5 percent ethyl acetate/hexanes as eluent