2-methyldecanamide

反応条件: temp:2.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 2-Methyl decanamide (50 g, 270 mmol) was suspended in 300 ml of methylene chloride, cooled to 2° C. and aqueous HOCl (14.72 g, 280 mmol) was added over about 10 minutes. The mixture was stirred in the cold for 15 minutes, then at room temperature for 45 minutes. The methylene chloride layer was separated, dried over magnesium sulfate, and the solvent removed on a rotary evaporator in a warm water bath to give 56 g (94% yield) of white solid product, m.p. 56°-57° C. at room temperature for 45 minutes The methylene chloride layer was separated dried over magnesium sulfate the solvent removed on a rotary evaporator in a warm water bath

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 2-Methyl decanoyl chloride (68.9 g, 336 mmol) was added dropwise to rapidly stirred ammonium hydroxide (200 ml) cooled in an ice bath. The resulting white slurry was stirred at room temperature for one-half hour, then filtered through a Buchner funnel. The filter cake was washed with 100 ml of ice water, air-dried overnight, then dried in a vacuum over at 55° C. for 2 hours to give 53 g (85.5% yield) of a white solid product, m.p. 80°-81° C. (lit. m.p. 81.4° C.). cooled in an ice bath filtered through a Buchner funnel The filter cake was washed with 100 ml of ice water air-dried overnight dried in a vacuum over at 55° C. for 2 hours

反応条件: temp:2.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 2-Methyl decanamide (50 g, 270 mmol) was suspended in 300 ml of methylene chloride, cooled to 2° C. and aqueous HOCl (14.72 g, 280 mmol) was added over about 10 minutes. The mixture was stirred in the cold for 15 minutes, then at room temperature for 45 minutes. The methylene chloride layer was separated, dried over magnesium sulfate, and the solvent removed on a rotary evaporator in a warm water bath to give 56 g (94% yield) of white solid product, m.p. 56°-57° C. at room temperature for 45 minutes The methylene chloride layer was separated dried over magnesium sulfate the solvent removed on a rotary evaporator in a warm water bath

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 2-Methyl decanoyl chloride (68.9 g, 336 mmol) was added dropwise to rapidly stirred ammonium hydroxide (200 ml) cooled in an ice bath. The resulting white slurry was stirred at room temperature for one-half hour, then filtered through a Buchner funnel. The filter cake was washed with 100 ml of ice water, air-dried overnight, then dried in a vacuum over at 55° C. for 2 hours to give 53 g (85.5% yield) of a white solid product, m.p. 80°-81° C. (lit. m.p. 81.4° C.). cooled in an ice bath filtered through a Buchner funnel The filter cake was washed with 100 ml of ice water air-dried overnight dried in a vacuum over at 55° C. for 2 hours