(2S)-N-methyl-1-phenylpropan-2-amine

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: The polarization value for a sample is compared to a standard curve prepared using calibrators of known amphetamine or d-methamphetamine content. prepared

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: The polarization value for a sample is compared to a standard curve prepared using calibrators of known amphetamine or d-methamphetamine content. prepared

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A solution of 11.9 g (0.05 mole) of 5-(4-nitrophenyl)furfuryl chloride and 14.9 g (0.10 mole) of d-N,a-dimethylphenethylamine in 60 ml of benzene was heated under reflux for 7 hrs. After standing overnight, the solid N,a-dimethylphenethylamine hydrochloride (9 g, 97%) was collected by filtration and washed with benzene. The benzene filtrate was washed with 10% Na2CO3 and water and dried over MgSO4. The solvent was removed on a rotary evaporator, and the residual oil was dissolved in 100 ml of anhydrous ether and 35 ml of nhydrous MeOH. The solution was treated with 20 ml of ethereal HCl and diluted with ether to give an oil. The solvent was removed on a rotary evaporator, and the residual oil was dissolved in ethyl acetate with heating. Cooling gave an oil which was dissolved by the addition of MeOH and 10 ml of etheral HCl. After cooling and dilution with ether, the yellow solid which was deposited was collected by filtration to give 13 g (67%) of N-methyl-5-(4-nitrophenyl)-N-(a-methylphenethyl)furfurylamine hydrochloride; m.p. 168°-175°. under reflux for 7 hrs the solid N,a-dimethylphenethylamine hydrochloride (9 g, 97%) was collected by filtration washed with benzene The benzene filtrate was washed with 10% Na2CO3 and water dried over MgSO4 The solvent was removed on a rotary evaporator the residual oil was dissolved in 100 ml of anhydrous ether The solution was treated with 20 ml of ethereal HCl diluted with ether to give an oil The solvent was removed on a rotary evaporator the residual oil was dissolved in ethyl acetate with heating Cooling gave an oil which After cooling dilution with ether, the yellow solid which was deposited was collected by filtration

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A solution of 11.9 g (0.05 mole) of 5-(4-nitrophenyl)furfuryl chloride and 14.9 g (0.10 mole) of d-N,a-dimethylphenethylamine in 60 ml of benzene was heated under reflux for 7 hrs. After standing overnight, the solid N,a-dimethylphenethylamine hydrochloride (9 g, 97%) was collected by filtration and washed with benzene. The benzene filtrate was washed with 10% Na2CO3 and water and dried over MgSO4. The solvent was removed on a rotary evaporator, and the residual oil was dissolved in 100 ml of anhydrous ether and 35 ml of nhydrous MeOH. The solution was treated with 20 ml of ethereal HCl and diluted with ether to give an oil. The solvent was removed on a rotary evaporator, and the residual oil was dissolved in ethyl acetate with heating. Cooling gave an oil which was dissolved by the addition of MeOH and 10 ml of etheral HCl. After cooling and dilution with ether, the yellow solid which was deposited was collected by filtration to give 13 g (67%) of N-methyl-5-(4-nitrophenyl)-N-(a-methylphenethyl)furfurylamine hydrochloride; m.p. 168°-175°. under reflux for 7 hrs the solid N,a-dimethylphenethylamine hydrochloride (9 g, 97%) was collected by filtration washed with benzene The benzene filtrate was washed with 10% Na2CO3 and water dried over MgSO4 The solvent was removed on a rotary evaporator the residual oil was dissolved in 100 ml of anhydrous ether The solution was treated with 20 ml of ethereal HCl diluted with ether to give an oil The solvent was removed on a rotary evaporator the residual oil was dissolved in ethyl acetate with heating Cooling gave an oil which After cooling dilution with ether, the yellow solid which was deposited was collected by filtration

反応条件: temp:100.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Amphetamine free base (100 mg, 0.71 mmol) was dissolved in ethyl formate (10 mL). The solution was heated under pressure in an ACE pressure reactor for 2 hours at 100° C. The reaction mixture was cooled to ambient temperature, and the solvent was evaporated under reduced pressure. The resulting carbamate derivative was dissolved in dried diethyl ether (5 mL). The solution was added dropwise to a suspension of lithium aluminium hydride (40.4 mg, 1.07 mmol) in dry diethyl ether (10 mL). The reaction mixture was refluxed for 5 hours. Thereafter, water was carefully added after the reaction mixture had been cooled down to 0° C. on an ice bath. The lithium salt was filtered over Celite™ diatomaceous earth in a Buchner funnel. The granules obtained were washed thoroughly with excess diethyl ether. The combined ether phases were washed with 5% sodium hydroxide and brine before being dried over magnesium sulfate. The solvent was evaporated to yield 96 mg methamphetamine free base. The reaction mixture was cooled to ambient temperature the solvent was evaporated under reduced pressure The resulting carbamate derivative was dissolved in dried diethyl ether (5 mL) The reaction mixture was refluxed for 5 hours had been cooled down to 0° C. on an ice bath The lithium salt was filtered over Celite™ diatomaceous earth in a Buchner funnel The granules obtained were washed thoroughly with excess diethyl ether The combined ether phases were washed with 5% sodium hydroxide and brine before being dried over magnesium sulfate The solvent was evaporated

反応条件: temp:100.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Amphetamine free base (100 mg, 0.71 mmol) was dissolved in ethyl formate (10 mL). The solution was heated under pressure in an ACE pressure reactor for 2 hours at 100° C. The reaction mixture was cooled to ambient temperature, and the solvent was evaporated under reduced pressure. The resulting carbamate derivative was dissolved in dried diethyl ether (5 mL). The solution was added dropwise to a suspension of lithium aluminium hydride (40.4 mg, 1.07 mmol) in dry diethyl ether (10 mL). The reaction mixture was refluxed for 5 hours. Thereafter, water was carefully added after the reaction mixture had been cooled down to 0° C. on an ice bath. The lithium salt was filtered over Celite™ diatomaceous earth in a Buchner funnel. The granules obtained were washed thoroughly with excess diethyl ether. The combined ether phases were washed with 5% sodium hydroxide and brine before being dried over magnesium sulfate. The solvent was evaporated to yield 96 mg methamphetamine free base. The reaction mixture was cooled to ambient temperature the solvent was evaporated under reduced pressure The resulting carbamate derivative was dissolved in dried diethyl ether (5 mL) The reaction mixture was refluxed for 5 hours had been cooled down to 0° C. on an ice bath The lithium salt was filtered over Celite™ diatomaceous earth in a Buchner funnel The granules obtained were washed thoroughly with excess diethyl ether The combined ether phases were washed with 5% sodium hydroxide and brine before being dried over magnesium sulfate The solvent was evaporated

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: The polarization value for a sample is compared to a standard curve prepared using calibrators of known amphetamine or d-methamphetamine content. prepared

反応条件: temp:100.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Amphetamine free base (100 mg, 0.71 mmol) was dissolved in ethyl formate (10 mL). The solution was heated under pressure in an ACE pressure reactor for 2 hours at 100° C. The reaction mixture was cooled down, and the solvent was evaporated under reduced pressure. The resulting carbamate derivative was dissolved in dried diethyl ether (5 mL). The solution was added dropwise to a suspension of lithium aluminium hydride (40.4 mg, 1.07 mmol) in diethyl ether (10 mL). The reaction mixture was refluxed for 5 hours. Thereafter, water was carefully added after the reaction mixture had been cooled down to 0° C. on an ice bath. The lithium salt was filtered over Celite™ diatomaceous earth in Buchner funnel. The granules obtained were washed thoroughly with excess diethyl ether. The combined ether phases were washed with 5% sodium hydroxide and brine before being dried with magnesium sulfate. The solvent was evaporated to yield 96 mg methamphetamine free base. The reaction mixture was cooled down the solvent was evaporated under reduced pressure The resulting carbamate derivative was dissolved in dried diethyl ether (5 mL) The reaction mixture was refluxed for 5 hours had been cooled down to 0° C. on an ice bath The lithium salt was filtered over Celite™ diatomaceous earth in Buchner funnel The granules obtained were washed thoroughly with excess diethyl ether The combined ether phases were washed with 5% sodium hydroxide and brine before being dried with magnesium sulfate The solvent was evaporated

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: In the dissolving metal reduction method of methamphetamine synthesis, the ephedrine or pseudo-ephedrine starting ingredient is obtained, often by extraction from over-the-counter cold medication. Anhydrous ammonia is obtained, typically by theft from agricultural supplies. Lithium metal is obtained from lithium batteries. Lithium metal is dissolved in the liquid, anhydrous ammonia to give a blue colored solution, to which ephedrine is added. The ammonia is allowed to boil off leaving the crude, free-base methamphetamine product, which is typically purified by common practice and converted to the hydrochloride salt. to give a blue colored solution

反応条件: temp:100.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Amphetamine free base (100 mg, 0.71 mmol) was dissolved in ethyl formate (10 mL). The solution was heated under pressure in an ACE pressure reactor for 2 hours at 100° C. The reaction mixture was cooled down, and the solvent was evaporated under reduced pressure. The resulting carbamate derivative was dissolved in dried diethyl ether (5 mL). The solution was added dropwise to a suspension of lithium aluminium hydride (40.4 mg, 1.07 mmol) in diethyl ether (10 mL). The reaction mixture was refluxed for 5 hours. Thereafter, water was carefully added after the reaction mixture had been cooled down to 0° C. on an ice bath. The lithium salt was filtered over Celite™ diatomaceous earth in Buchner funnel. The granules obtained were washed thoroughly with excess diethyl ether. The combined ether phases were washed with 5% sodium hydroxide and brine before being dried with magnesium sulfate. The solvent was evaporated to yield 96 mg methamphetamine free base. The reaction mixture was cooled down the solvent was evaporated under reduced pressure The resulting carbamate derivative was dissolved in dried diethyl ether (5 mL) The reaction mixture was refluxed for 5 hours had been cooled down to 0° C. on an ice bath The lithium salt was filtered over Celite™ diatomaceous earth in Buchner funnel The granules obtained were washed thoroughly with excess diethyl ether The combined ether phases were washed with 5% sodium hydroxide and brine before being dried with magnesium sulfate The solvent was evaporated

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: In the dissolving metal reduction method of methamphetamine synthesis, the ephedrine or pseudo-ephedrine starting ingredient is obtained, often by extraction from over-the-counter cold medication. Anhydrous ammonia is obtained, typically by theft from agricultural supplies. Lithium metal is obtained from lithium batteries. Lithium metal is dissolved in the liquid, anhydrous ammonia to give a blue colored solution, to which ephedrine is added. The ammonia is allowed to boil off leaving the crude, free-base methamphetamine product, which is typically purified by common practice and converted to the hydrochloride salt. to give a blue colored solution

反応条件: temp:120.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: To a 100 ml 3-neck flask fitted with a mechanical stirrer was added 17.10 g (0.1145 moles) of methamphetamine, 14.50 g (0.1368 mole) of sodium carbonate and 10.60 g of toluene. The reaction mass was heated to 120° C. and 16.18 g (0.1265 mole) of benzyl chloride was added over 180 minutes. The reaction was continued for a total of 6.75 hr. The reaction mass was cooled and transferred to a 500 ml flask equipped with a mechanical stirrer. To this flask was added 45 ml of toluene and 90 ml of water. The mixture was aggressively stirred to dissolve the salt. The layers were separated and the water layer was washed twice with 20 ml portions of toluene. The combined toluene layers were washed with 20 ml of water. Then to the stirred toluene layer was added 11.33 g of concentrated hydrochloric acid. The flask was equipped with a Dean-Stark trap and condenser and the water was removed by azeotropic distillation. There was 8.9 g of water recovered from the Dean-Stark trap. The organic material crystallized upon cooling between about 60° C. to about 40° C. affording 19.79 g of crude benzphetamine hydrochloride which is a 70% yield. To a 100 ml 3-neck flask fitted with a mechanical stirrer was continued for a total of 6.75 hr The reaction mass was cooled transferred to a 500 ml flask equipped with a mechanical stirrer to dissolve the salt The layers were separated the water layer was washed twice with 20 ml portions of toluene The combined toluene layers were washed with 20 ml of water Then to the stirred toluene layer was added 11.33 g of concentrated hydrochloric acid The flask was equipped with a Dean-Stark trap and condenser the water was removed by azeotropic distillation recovered from the Dean-Stark trap The organic material crystallized upon cooling between about 60° C. to about 40° C.