2-phenylethylhydrazine;hydrochloride

反応条件: temp:90.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: To a solution of 5.7 g. 2,2-dichloropropionic acid and 2.8 g. potassium carbonate in 40 ml water is added a solution of 6.9 g. phenethylhydrazine hydrochloride and 5.6 g. potassium carbonate in 20 ml water. The mixture is heated with stirring to 90° C., a further solution of 5.6 g. potassium carbonate in 20 ml water is dropped in over 30 minutes and further stirred for 60 minutes at 90° C. Afterwards the still alkaline solution is cooled to ambient temperature, shaken out with ether and acidified with concentrated hydrochloric acid. 2-(phenethylhydrazono)-propionic acid crystallizes out and is recrystallized from toluene. The yield is 3.3 g. (40% of theory); m.p. 74°-76° C. The mixture is heated further stirred for 60 minutes at 90° C Afterwards the still alkaline solution is cooled to ambient temperature 2-(phenethylhydrazono)-propionic acid crystallizes out is recrystallized from toluene

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 3.4 g. Phenethylhydrazine hydrochloride are dissolved in 10 ml. water and mixed with 1.7 g. pyruvamide dissolved in 50 ml. water. 2.1 g. sodium acetate trihydrate are added thereto and the reaction mixture well shaken up. 2-(Phenethylhydrazono)-propionamide crystallizes out. It is filtered off and recrystallized from a mixture of cyclohexane and toluene. The yield is 2.0 g. (50% of theory); m.p. 78° C. (decomp.). 2-(Phenethylhydrazono)-propionamide crystallizes out It is filtered off recrystallized from a mixture of cyclohexane and toluene

反応条件: temp:0.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 3.6 g. Phenethylhydrazine hydrochloride and 2.0 g. methyl pyruvate are dissolved in 20 ml. methanol and left to stand at ambient temperature for 30 minutes, followed by cooling to 0° C., whereafter 30 ml. water are added thereto. 2.8 g. (61% of theory) methyl 2-(phenethylhydrazono)-propionate crystallizes out; m.p. 59°-60° C. (decomp.). (61% of theory) methyl 2-(phenethylhydrazono)-propionate crystallizes out