magnesium;octadecanoate

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Metformin hydrochloride is screened through 1 mm sieve. Screened metformin hydrochloride and hydroxypropylmethylcellulose are granulated in fluid bed granulator with demineralized water and dried in the same device. Dried granulate is screened through 1 mm sieve. Obtained granulate and microcrystalline cellulose are homogenously blended in a bin blender. Pre-sieved magnesium stearate is added to the obtained blend and blended in a bin blender so that the final blend is obtained. dried in the same device Dried granulate Obtained granulate is obtained

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Separately, prochlorperazine was added to and blended with the mannitol (Part B). Parts A and B were then combined and mixed for about 5 minutes in a V-shaped blender. Next, magnesium stearate was added to the blender, followed by continued blending for about 2 minutes. mixed for about 5 minutes in a V-shaped blender

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: In a twin shell blender were placed 369.6 grams of the dried wet granulation of Example 3, 369.6 grams glyceryl monostearate (Myvaplex® 600, Eastman Chemical Co.), 33.2 grams of aspartame (The NutraSweet Co.), 21.6 grams of apple cinnamon durarome #860.310/TD 05.91 (Firminich Inc.), and 27.6 grams of an artificial special compound flavor (Firminish Inc.). This mixture was blended for 10 minutes after which 138.6 grams of Pregelatinized Starch (Starch 1500 Colorcon), 969.8 grams of granular mannitol, and 27.6 grams of crosslinked sodium carboxymethylcellulose (Accelerate™, FMC Corporation) were added to the blender. Mixing was continued for 10 more minutes, and then 19.4 grams of magnesium stearate was added to the blender. Mixing was completed in five minutes. Prior to adding each material to the blender, it was passed through a Number 30 US Standard Sieve. This mixture was then compressed into a tablet. The particle size distribution of the granulation used in this formulation was determined by using a Sonic Sifter, a vibrated stack of U.S. Standard Sieves in which each succeeding sieve is finer in mesh than the one above it. The amount of product retained on each sieve provides the percentage of particles larger than that sieve, but smaller then the next higher sieve. Particles having sizes in each mesh range were: 48.23%>297 microns (>50 mesh); 29.657% 177-297 microns (50-80 mesh); 5.39% 149-177 microns (80-100 mesh); 13.57% 74-149 microns (100-200 mesh); 3.17% 53-74 microns (200-270 mesh); and 5.00%<53 microns (<270 mesh). The loose bulk density of this material was 0.6164 grams/mL. The water content of the granulation was 1.50%. Properties of the chewable tablets include tablet thickness (3.25 mm, 0.1279 inch), hardness (5.37 kiloponds), and disintegration time in 37° C. purified water (184 seconds). All of these measurements were taken on ten tablets except disintegration time which used six tablets. The unpleasant flavor of ibuprofen was effectively masked by using the wet granulation in combination with other excipients. Mixing Mixing was completed in five minutes Prior to adding each material to the blender, it provides the percentage of particles larger than that sieve in 37° C. purified water (184 seconds)

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Fentanyl citrate, croscarmellose sodium and silicified microcrystalline cellulose, and then magnesium stearate, were all added and admixed under the same conditions as those described in Examples 1 and 2 above. The mixture was compressed as described in Example 2. all added

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Fentanyl citrate, croscarmellose sodium and silicified microcrystalline cellulose, and then magnesium stearate, were all added and admixed under the same conditions as those described in Examples 1 and 2 above. The mixture was compressed as described in Example 2. all added

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Fentanyl citrate was added to the carrier material in amounts corresponding to a batch size of 300 tablets. Mixing was carried out under the same conditions as those described in Example 1. Croscarmellose sodium and silicified microcrystalline cellulose, and then magnesium stearate, were added and admixed under the same conditions as those described in Example 1. Mixing

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Basically 0.1 mg (base equivalent) of clonidine hydrochloride was blended with 13 mg of calcium phosphate dibasic, with 15 mg of microcrystalline cellulose, with 40 mg of hydroxypropyl methyl cellulose, 1 mg of colloidal silica and 0.9 mg of magnesium stearate.

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: An oxindole hydrazine derivative of formula (I) is admixed as a dry powder with a dry gelatin binder in an approximate 1:2 weight ratio. A minor amount of magnesium stearate is added as a lubricant. The mixture is formed into 240-270 mg tablets (80-90 mg of active oxindole hydrazide compound per tablet) in a tablet press.

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: The procedure is similar to that of Example 1, except that the amounts of the components used are: bazedoxifene acetate (1,128 g), AVICEL PH101® (microcrystalline cellulose) (4,036 g), lactose NF (fast flow; 4,036 g), ascorbic acid (300 g), sodium starch glycolate (400 g) and magnesium stearate (100 g).

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: The procedure is similar to that of Example 1, except that the amounts of the components used are: bazedoxifene acetate (1,128 g), AVICEL PH101® (microcrystalline cellulose) (4,036 g), lactose NF (fast flow; 4,036 g), ascorbic acid (300 g), sodium starch glycolate (400 g) and magnesium stearate (100 g).

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Stearic acid and magnesium oxide were reacted to yield a reaction product of magnesium stearate, water and an excess of magnesium oxide. To this end 50 grams of 60-70 micron, technical grade (95% purity) magnesium oxide, known to exhibit medium reactivity with stearic acid, was introduced into the open-topped reactor.

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Stearic acid and magnesium oxide were reacted to yield a reaction product of magnesium stearate, water and an excess of magnesium oxide. To this end 50 grams of 60-70 micron, technical grade (95% purity) magnesium oxide, known to exhibit medium reactivity with stearic acid, was introduced into the open-topped reactor.