3-(1,3-dioxoisoindol-2-yl)propanethioamide

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 2-Bromo-1-indanone, 3-phthalimidopropanethioamide

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 2-Bromo-1-indanone, 3-phthalimidopropanethioamide

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 2-Bromo-1-indanone, 3-phthalimidopropanethioamide

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: To a suspension of 3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-thiopropionamide (2.13 g, 9.09 mmol) in acetone (30 mL) was added iodomethane (3.87 g, 1.71 mL, 27.3 mmol) at r. t. under a nitrogen atmosphere. The reaction mixture was stirred at RT for 48 h and the obtained suspension was filtered, washed with diethyl ether and dried in vacuo to give the product as light yellow solid (2.3 g, 6.11 mmol, 67.2%). MS: M=249.1 (M+H)+ the obtained suspension was filtered washed with diethyl ether dried in vacuo

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A suspension of 3-(1,3-dioxoisoindolin-2-yl)-propionitrile (2 g, 9.99 mmol) and dithiophosphoric acid O,O′-diethyl ester (2.05 g, 1.74 mL, 11.0 mmol) in water (4 mL) was irradiated at 80° C. for 10 min. The obtained suspension was diluted with water (5 mL), filtered, washed with water and dried in vacuo to give the product as light yellow solid (2.13 g, 9.09 mmol, 91.0%) which was used without further purification for the next step. MS: M=235.1 (M+H)+ was irradiated at 80° C. for 10 min filtered washed with water dried in vacuo

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 2-Bromo-1-indanone, 3-phthalimidopropanethioamide