3-(2,6-dichlorophenoxy)propan-1-amine

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Intermediate 12 (55 mg, 0.250 mmol, 88% yield) was prepared as a white powder following the procedure described for Intermediate 9 using 2,3-dichlorophenol and 2,6-dichlorophenol as starting materials. LC-MS (ESI) 221 (M+H), RT=1.48 min (Method B).

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Intermediate 11 (150 mg, 0.808 mmol, 85% yield) was prepared as a white powder following the procedure described for Intermediate 9 replacing 2,6-dichlorophenol with 4-chlorophenol as starting material. LC-MS (ESI) 186 (M+H), RT=1.41 min (Method B).

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Intermediate 10 (50 mg, 0.228 mmol, 80% yield) was prepared as a white powder following the procedure described for Intermediate 9 using 2-trifluoromethylphenol and 2.6-dichlorophenol as starting materials. LC-MS (ESI) 220 (M+H), RT=1.36 min (Method B).