2-(2,4-dichlorophenoxy)propanoyl chloride

反応条件: temp:0.00; pressure:0.00; stir:

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A mixture of 25 g of 2-(2',4'-dichloro-phenoxy)-propionyl chloride and 30 ml of ether is added dropwise to a 35% etheral solution of magnesium-diethyl malonate prepared from 17.6 g of diethyl malonate. When the addition of the acid chloride is completed the reaction mixture is heated to boiling for an hour and worked up as described in Example 1. Thus 29 g of the desired compound are obtained in the form of a yellow oil, yield 76%, nD25 =1,355. is heated to boiling for an hour

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A mixture of 25 g of 2-(2',4'-dichloro-phenoxy)-propionyl chloride and 30 ml of ether is added dropwise to a 35% etheral solution of magnesium-diethyl malonate prepared from 17.6 g of diethyl malonate. When the addition of the acid chloride is completed the reaction mixture is heated to boiling for an hour and worked up as described in Example 1. Thus 29 g of the desired compound are obtained in the form of a yellow oil, yield 76%, nD25 =1,355. is heated to boiling for an hour

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: In an analogous manner, from 2(RS)-(2,4-dichlorophenoxy)propionyl chloride (prepared from the acid) and 5'-amino-2',5'-dideoxy-3'-O-ethyl-5-ethyluridine, there was obtained 5'-[2(RS)-(2,4-dichlorophenoxy)propionamido]-2',5'-dideoxy-3'-O-ethyl-5-ethyluridine of melting point 121°-124° C.

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: In an analogous manner, from 2(RS)-(2,4-dichlorophenoxy)propionyl chloride (prepared from the acid) and 5'-amino-2',5'-dideoxy-3'-O-ethyl-5-ethyluridine, there was obtained 5'-[2(RS)-(2,4 -dichlorophenoxy)propionamido]-2',5'-dideoxy-3'O-ethyl-5-ethyluridine of melting point 121°-124° C.

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: In an analogous manner, from 2(RS)-(2,4-dichlorophenoxy)propionyl chloride (prepared from the acid) and 5'-amino-2',5'-dideoxy-3'-O-ethyl-5-ethyluridine, there was obtained 5'-[2(RS)-(2,4 -dichlorophenoxy)propionamido]-2',5'-dideoxy-3'O-ethyl-5-ethyluridine of melting point 121°-124° C.

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A mixture of 25 g of 2-(2',4'-dichloro-phenoxy)-propionyl chloride and 30 ml of ether is added dropwise to a 35% etheral solution of magnesium-diethyl malonate prepared from 17.6 g of diethyl malonate. When the addition of the acid chloride is completed the reaction mixture is heated to boiling for an hour and worked up as described in Example 1. Thus 29 g of the desired compound are obtained in the form of a yellow oil, yield 76%, nD25 =1,355. is heated to boiling for an hour

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: In an analogous manner, from 2(RS)-(2,4-dichlorophenoxy)propionyl chloride (prepared from the acid) and 5'-amino-2',5'-dideoxy-3'-O-ethyl-5-ethyluridine, there was obtained 5'-[2(RS)-(2,4-dichlorophenoxy)propionamido]-2',5'-dideoxy-3'-O-ethyl-5-ethyluridine of melting point 121°-124° C.

反応条件: temp:0.00; pressure:0.00; stir:

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: In an analogous manner, from 2(RS)-(2,4-dichlorophenoxy)propionyl chloride (prepared from the acid) and 5'-amino-2',5'-dideoxy-3'-O-ethyl-5-ethyluridine, there was obtained 5'-[2(RS)-(2,4 -dichlorophenoxy)propionamido]-2',5'-dideoxy-3'O-ethyl-5-ethyluridine of melting point 121°-124° C.

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A mixture of 25 g of 2-(2',4'-dichloro-phenoxy)-propionyl chloride and 30 ml of ether is added dropwise to a 35% etheral solution of magnesium-diethyl malonate prepared from 17.6 g of diethyl malonate. When the addition of the acid chloride is completed the reaction mixture is heated to boiling for an hour and worked up as described in Example 1. Thus 29 g of the desired compound are obtained in the form of a yellow oil, yield 76%, nD25 =1,355. is heated to boiling for an hour

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: In an analogous manner, from 2(RS)-(2,4-dichlorophenoxy)propionyl chloride (prepared from the acid) and 5'-amino-2',5'-dideoxy-3'-O-ethyl-5-ethyluridine, there was obtained 5'-[2(RS)-(2,4-dichlorophenoxy)propionamido]-2',5'-dideoxy-3'-O-ethyl-5-ethyluridine of melting point 121°-124° C.