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COC(=O)CCCCCCCN製品情報
methyl 8-aminooctanoate (CAS 59080-49-8) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
想定用途
専門的研究・工業用途限定
データベース ID 12878163
安全上の注意
For professional research and industrial use only. Review the supplier safety data sheet before handling.
合成データ
10 反応 · 10 文献
反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-31af3eafe3ae42c8a069ab6eafb698c0反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-c4f95a058be44baabaa707ad929cd434反応条件: temp:-5.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: To 15 ml methanol under nitrogen, stirred, at −5° C. was added thionyl chloride (0.80 ml) dropwise. After 5 minutes, 8-aminooctanoic acid (1.592 g, 10 mmol) was added. The reaction was stirred at −5° C. for 1 h, room temperature for 45 minutes, and 40° C. for 2.25 h. After heating, the reaction mixture was concentrated. The residue was taken up in chloroform/water (40 ml/25 ml) and basified to pH 9-10 using 1N NaOH. Layers were shaken, separated and the aqueous layer washed with water (2×30 ml). The combined organics were dried over Na2SO4 and filtered. The filtrate was concentrated in vac and dried to give the product as an oily solid (1.568 g, 90%); 1H NMR (400 MHz, DMSO-d6) δ1.17-1.33 (m, 8H), 1.43-1.52 (m, 2H), 2.26 (t, J=7.5Hz, 2H), 2.44-2.49 (m, 2H), 3.55 (s, 3H); IR (film) 3475, 2930, 2850, 1730 cm−1; mass spectrum [EI], m/z 173 M+. 40° C. for 2.25 h After heating the reaction mixture was concentrated Layers were shaken separated the aqueous layer washed with water (2×30 ml) The combined organics were dried over Na2SO4 filtered The filtrate was concentrated in vac dried
ソース ID: ord-eeb85ccec7c0406db7e3b835050ebb0a反応条件: temp:-5.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: To 15 ml methanol under nitrogen, stirred, at −5° C. was added thionyl chloride (0.80 ml) dropwise. After 5 minutes, 8-aminooctanoic acid (1.592 g, 10 mmol) was added. The reaction was stirred at −5° C. for 1 h, room temperature for 45 minutes, and 40° C. for 2.25 h. After heating, the reaction mixture was concentrated. The residue was taken up in chloroform/water (40 ml/25 ml) and basified to pH 9-10 using 1N NaOH. Layers were shaken, separated and the aqueous layer washed with water (2×30 ml). The combined organics were dried over Na2SO4 and filtered. The filtrate was concentrated in vac and dried to give the product as an oily solid (1.568 g, 90%); 1H NMR (400 MHz, DMSO-d6) δ1.17-1.33 (m, 8H), 1.43-1.52 (m, 2H), 2.26 (t, J=7.5Hz, 2H), 2.44-2.49 (m, 2H), 3.55 (s, 3H); IR (film) 3475, 2930, 2850, 1730 cm−1; mass spectrum [EI], m/z 173 M+. 40° C. for 2.25 h After heating the reaction mixture was concentrated Layers were shaken separated the aqueous layer washed with water (2×30 ml) The combined organics were dried over Na2SO4 filtered The filtrate was concentrated in vac dried
ソース ID: ord-eeb85ccec7c0406db7e3b835050ebb0a反応条件: temp:-5.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: To 15 ml methanol under nitrogen, stirred, at −5° C. was added thionyl chloride (0.80 ml) dropwise. After 5 minutes, 8-aminooctanoic acid (1.592 g, 10 mmol) was added. The reaction was stirred at −5° C. for 1 h, room temperature for 45 minutes, and 40° C. for 2.25 h. After heating, the reaction mixture was concentrated. The residue was taken up in chloroform/water (40 ml/25 ml) and basified to pH 9-10 using 1N NaOH. Layers were shaken, separated and the aqueous layer washed with water (2×30 ml). The combined organics were dried over Na2SO4 and filtered. The filtrate was concentrated in vac and dried to give the product as an oily solid (1.568 g, 90%); 1H NMR (400 MHz, DMSO-d6) δ1.17-1.33 (m, 8H), 1.43-1.52 (m, 2H), 2.26 (t, J=7.5Hz, 2H), 2.44-2.49 (m, 2H), 3.55 (s, 3H); IR (film) 3475, 2930, 2850, 1730 cm−1; mass spectrum [EI], m/z 173 M+. 40° C. for 2.25 h After heating the reaction mixture was concentrated Layers were shaken separated the aqueous layer washed with water (2×30 ml) The combined organics were dried over Na2SO4 filtered The filtrate was concentrated in vac dried
ソース ID: ord-eeb85ccec7c0406db7e3b835050ebb0a反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-c4f95a058be44baabaa707ad929cd434反応条件: temp:-5.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: To 15 ml methanol under nitrogen, stirred, at −5° C. was added thionyl chloride (0.80 ml) dropwise. After 5 minutes, 8-aminooctanoic acid (1.592 g, 10 mmol) was added. The reaction was stirred at −5° C. for 1 h, room temperature for 45 minutes, and 40° C. for 2.25 h. After heating, the reaction mixture was concentrated. The residue was taken up in chloroform/water (40 ml/25 ml) and basified to pH 9-10 using 1N NaOH. Layers were shaken, separated and the aqueous layer washed with water (2×30 ml). The combined organics were dried over Na2SO4 and filtered. The filtrate was concentrated in vac and dried to give the product as an oily solid (1.568 g, 90%); 1H NMR (400 MHz, DMSO-d6) δ 1.17-1.33 (m, 8H), 1.43-1.52 (m, 2H), 2.26 (t, J=7.5 Hz, 2H), 2.44-2.49 (m, 2H), 3.55 (s, 3H); IR (film) 3475, 2930, 2850, 1730 cm−1; mass spectrum [EI], m/z 173 M+. 40° C. for 2.25 h After heating the reaction mixture was concentrated Layers were shaken separated the aqueous layer washed with water (2×30 ml) The combined organics were dried over Na2SO4 filtered The filtrate was concentrated in vac dried
ソース ID: ord-394a231ac3f94237b4fbf978bc96f6e5反応条件: temp:-5.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: To 15 ml methanol under nitrogen, stirred, at −5° C. was added thionyl chloride (0.80 ml) dropwise. After 5 minutes, 8-aminooctanoic acid (1.592 g, 10 mmol) was added. The reaction was stirred at −5° C. for 1 h, room temperature for 45 minutes, and 40° C. for 2.25 h. After heating, the reaction mixture was concentrated. The residue was taken up in chloroform/water (40 ml/25 ml) and basified to pH 9–10 using 1N NaOH. Layers were shaken, separated and the aqueous layer washed with water (2×30 ml). The combined organics were dried over Na2SO4 and filtered. The filtrate was concentrated in vac and dried to give the product as an oily solid (1.568 g, 90%); 1H NMR (400 MHz, DMSO-d6) δ 1.17–1.33 (m, 8H), 1.43–1.52 (m, 2H), 2.26 (t, J=7.5 Hz, 2H), 2.44–2.49 (m, 2H), 3.55 (s, 3H); IR (film) 3475, 2930, 2850, 1730 cm−1; mass spectrum [EI], m/z 173 M+. 40° C. for 2.25 h After heating the reaction mixture was concentrated Layers were shaken separated the aqueous layer washed with water (2×30 ml) The combined organics were dried over Na2SO4 filtered The filtrate was concentrated in vac dried
ソース ID: ord-a25b7382382245d08082cff67293cf54反応条件: temp:-5.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: To 15 ml methanol under nitrogen, stirred, at −5° C. was added thionyl chloride (0.80 ml) dropwise. After 5 minutes, 8-aminooctanoic acid (1.592 g, 10 mmol) was added. The reaction was stirred at −5° C. for 1 h, room temperature for 45 minutes, and 40° C. for 2.25 h. After heating, the reaction mixture was concentrated. The residue was taken up in chloroform/water (40 ml/25 ml) and basified to pH 9-10 using 1N NaOH. Layers were shaken, separated and the aqueous layer washed with water (2×30 ml). The combined organics were dried over Na2SO4 and filtered. The filtrate was concentrated in vac and dried to give the product as an oily solid (1.568 g, 90%); 1H NMR (400 MHz, DMSO-d6) δ 1.17-1.33 (m, 8H), 1.43-1.52 (m, 2H), 2.26 (t, J=7.5 Hz, 2H), 2.44-2.49 (m, 2H), 3.55 (s, 3H); IR (film) 3475, 2930, 2850, 1730 cm−1; mass spectrum [EI], m/z 173 M+. 40° C. for 2.25 h After heating the reaction mixture was concentrated Layers were shaken separated the aqueous layer washed with water (2×30 ml) The combined organics were dried over Na2SO4 filtered The filtrate was concentrated in vac dried
ソース ID: ord-dd88776abe0a4692a74fac8985c54c2a反応条件: temp:-5.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: To 15 ml methanol under nitrogen, stirred, at −5° C. was added thionyl chloride (0.80 ml) dropwise. After 5 minutes, 8-aminooctanoic acid (1.592 g, 10 mmol) was added. The reaction was stirred at −5° C. for 1 h, room temperature for 45 minutes, and 40° C. for 2.25 h. After heating, the reaction mixture was concentrated. The residue was taken up in chloroform/water (40 ml/25 ml) and basified to pH 9-10 using 1N NaOH. Layers were shaken, separated and the aqueous layer washed with water (2×30 ml). The combined organics were dried over Na2SO4 and filtered. The filtrate was concentrated in vac and dried to give the product as an oily solid (1.568 g, 90%); 1H NMR (400 MHz, DMSO-d6) δ1.17-1.33 (m, 8H), 1.43-1.52 (m, 2H), 2.26 (t, J=7.5Hz, 2H), 2.44-2.49 (m, 2H), 3.55 (s, 3H); IR (film) 3475, 2930, 2850, 1730 cm−1; mass spectrum [EI], m/z 173 M+. 40° C. for 2.25 h After heating the reaction mixture was concentrated Layers were shaken separated the aqueous layer washed with water (2×30 ml) The combined organics were dried over Na2SO4 filtered The filtrate was concentrated in vac dried
ソース ID: ord-eeb85ccec7c0406db7e3b835050ebb0aPubChem References
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