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C1CCC(CC1)C2=CC=CC=C2Br製品情報
1-bromo-2-cyclohexylbenzene (CAS 59734-92-8) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
想定用途
専門的研究・工業用途限定
データベース ID 10944502
安全上の注意
For professional research and industrial use only. Review the supplier safety data sheet before handling.
合成データ
12 反応 · 12 文献
反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-c530e504b3c54f479ebcb42cb39f9992反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-7bc719537e044d72b510a29e12c9354a反応条件: temp:80.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: To a solution of 1-bromo-2-cyclohexyl-benzene (5 mmol) in dioxane (20 mL) was added solid Pd(OAc)2 (0.1 g) and solid CsCO3 (10 mmol). tert-Butyl carbamate (7 mmol) was added to the reaction mixture, and the contents were heated at 80° C. for 2 h. The reaction mixture was cooled to room temperature and filtered through Celite. The solvent was removed in vacuo and the residue obtained was purified by flash column chromatography using DCM as eluant to yield (2-cyclohexylphenyl)-carbamic acid tert-butyl ester. The reaction mixture was cooled to room temperature filtered through Celite The solvent was removed in vacuo the residue obtained was purified by flash column chromatography
ソース ID: ord-5c9aa02c09ef4d0abbfa50e646441744反応条件: temp:80.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: To a solution of 1-bromo-2-cyclohexyl-benzene (5 mmol) in dioxane (20 mL) was added solid Pd(OAc)2 (0.1 g) and solid CsCO3 (10 mmol). tert-Butyl carbamate (7 mmol) was added to the reaction mixture, and the contents were heated at 80° C. for 2 h. The reaction mixture was cooled to room temperature and filtered through Celite. The solvent was removed in vacuo and the residue obtained was purified by flash column chromatography using DCM as eluant to yield (2-cyclohexylphenyl)-carbamic acid tert-butyl ester. The reaction mixture was cooled to room temperature filtered through Celite The solvent was removed in vacuo the residue obtained was purified by flash column chromatography
ソース ID: ord-5c9aa02c09ef4d0abbfa50e646441744反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-c530e504b3c54f479ebcb42cb39f9992反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-7bc719537e044d72b510a29e12c9354a反応条件: temp:130.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: A Schlenk tube was charged with CuI (9.6 mg, 0.050 mmol, 5.0 mol %), NaI (300 mg, 2.00 mmol), evacuated and backfilled with argon. Racemic trans-N,N′-dimethyl-1,2-cyclohexanediamine (16 μL, 0.10 mmol, 10 mol %), l-bromo-2-cyclohexylbenzene (97% pure; Lancaster; 186 μL, 1.00 mmol), n-pentanol (1 mL) were added under argon. The Schlenk tube was sealed with a Teflon valve and the reaction mixture was stirred at 130° C. for 40 h. The resulting suspension was allowed to reach room temperature and filtered through silica gel (1×0.5 cm) eluting with hexane (50 mL). The filtrate was concentrated, and the residue was purified by flash chromatography on silica gel (hexane) to provide the known 1-iodo-2-cyclohexylbenzene (283 mg, 99% yield; ca. 97% pure) as a colorless liquid. See McGuine, T. H.; Dull, M. F. J. Am. Chem. Soc. 1947, 69, 1469. 1H NMR (400 MHz, CDCl3): δ 7.85 (dd, J=7.5, 1.2 Hz, 1H), 7.32 (td, J=7.5, 1.2 Hz, 1H), 7.23 (dd, J=7.5, 1.7 Hz, 1H), 6.90 (td, J=7.5, 1.7Hz, 1H), 2.81 (tt, J=11.7, 3.0Hz, 1H), 1.97-1.74 (m, 5H), 1.55-1.23 (m, 5H). 13C NMR (100 MHz, CDCl3): δ 149.3, 139.5, 128.4, 127.6, 126.6, 101.5, 48.5, 33.4, 26.8, 26.1. evacuated The Schlenk tube was sealed with a Teflon valve to reach room temperature filtered through silica gel (1×0.5 cm) eluting with hexane (50 mL) The filtrate was concentrated the residue was purified by flash chromatography on silica gel (hexane)
ソース ID: ord-0f075345864647c1a4f07abc094e3228反応条件: temp:130.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: A Schlenk tube was charged with CuI (9.6 mg, 0.050 mmol, 5.0 mol %), NaI (300 mg, 2.00 mmol), evacuated and backfilled with argon. Racemic trans-N,N′-dimethyl-1,2-cyclohexanediamine (16 μL, 0.10 mmol, 10 mol %), l-bromo-2-cyclohexylbenzene (97% pure; Lancaster; 186 μL, 1.00 mmol), n-pentanol (1 mL) were added under argon. The Schlenk tube was sealed with a Teflon valve and the reaction mixture was stirred at 130° C. for 40 h. The resulting suspension was allowed to reach room temperature and filtered through silica gel (1×0.5 cm) eluting with hexane (50 mL). The filtrate was concentrated, and the residue was purified by flash chromatography on silica gel (hexane) to provide the known 1-iodo-2-cyclohexylbenzene (283 mg, 99% yield; ca. 97% pure) as a colorless liquid. See McGuine, T. H.; Dull, M. F. J. Am. Chem. Soc. 1947, 69, 1469. 1H NMR (400 MHz, CDCl3): δ 7.85 (dd, J=7.5, 1.2 Hz, 1H), 7.32 (td, J=7.5, 1.2 Hz, 1H), 7.23 (dd, J=7.5, 1.7 Hz, 1H), 6.90 (td, J=7.5, 1.7Hz, 1H), 2.81 (tt, J=11.7, 3.0Hz, 1H), 1.97-1.74 (m, 5H), 1.55-1.23 (m, 5H). 13C NMR (100 MHz, CDCl3): δ 149.3, 139.5, 128.4, 127.6, 126.6, 101.5, 48.5, 33.4, 26.8, 26.1. evacuated The Schlenk tube was sealed with a Teflon valve to reach room temperature filtered through silica gel (1×0.5 cm) eluting with hexane (50 mL) The filtrate was concentrated the residue was purified by flash chromatography on silica gel (hexane)
ソース ID: ord-0f075345864647c1a4f07abc094e3228反応条件: temp:130.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: A Schlenk tube was charged with CuI (9.6 mg, 0.050 mmol, 5.0 mol %), NaI (300 mg, 2.00 mmol), evacuated and backfilled with argon. Racemic trans-N,N′-dimethyl-1,2-cyclohexanediamine (16 μL, 0.10 mmol, 10 mol %), 1-bromo-2-cyclohexylbenzene (97% pure; Lancaster; 186 μL, 1.00 mmol), n-pentanol (1 mL) were added under argon. The Schlenk tube was sealed with a Teflon valve and the reaction mixture was stirred at 130° C. for 40 h. The resulting suspension was allowed to reach room temperature and filtered through silica gel (1×0.5 cm) eluting with hexane (50 mL). The filtrate was concentrated, and the residue was purified by flash chromatography on silica gel (hexane) to provide the known 1-iodo-2-cyclohexylbenzene (283 mg, 99% yield; ca. 97% pure) as a colorless liquid. See McGuine, T. H.; Dull, M. F. J. Am. Chem. Soc. 1947, 69, 1469. 1H NMR (400 MHz, CDCl3): δ 7.85 (dd, J=7.5, 1.2 Hz, 1H), 7.32 (td, J=7.5, 1.2 Hz, 1H), 7.23 (dd, J=7.5, 1.7 Hz, 1H), 6.90 (td, J=7.5, 1.7 Hz, 1H), 2.81 (tt, J=11.7, 3.0 Hz, 1H), 1.97-1.74 (m, 5H), 1.55-1.23 (m, 5H). 13C NMR (100 MHz, CDCl3): δ 149.3, 139.5, 128.4, 127.6, 126.6, 101.5, 48.5, 33.4, 26.8, 26.1. evacuated The Schlenk tube was sealed with a Teflon valve to reach room temperature filtered through silica gel (1×0.5 cm) eluting with hexane (50 mL) The filtrate was concentrated the residue was purified by flash chromatography on silica gel (hexane)
ソース ID: ord-faa76bcfd4d44463ac98f807d34f7eee反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: The title compound was prepared in a manner similar to Preparation 1A except that piperazine was coupled to 1-bromo-2-cyclohexyl-benzene.
ソース ID: ord-3cdb742e61c4487c9b869839e9f4a628反応条件: temp:80.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: To a solution of 1-bromo-2-cyclohexyl-benzene (5 mmol) in dioxane (20 mL) was added solid Pd(OAc)2 (0.1 g) and solid CsCO3 (10 mmol). tert-Butyl carbamate (7 mmol) was added to the reaction mixture, and the contents were heated at 80° C. for 2 h. The reaction mixture was cooled to room temperature and filtered through Celite. The solvent was removed in vacuo and the residue obtained was purified by flash column chromatography using DCM as eluant to yield (2-cyclohexylphenyl)-carbamic acid tert-butyl ester. The reaction mixture was cooled to room temperature filtered through Celite The solvent was removed in vacuo the residue obtained was purified by flash column chromatography
ソース ID: ord-c95baa0a6cfb442ba34211686bcffc02反応条件: temp:80.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: To a solution of 1-bromo-2-cyclohexyl-benzene (5 mmol) in dioxane (20 mL) was added solid Pd(OAc)2 (0.1 g) and solid CsCO3 (10 mmol). tert-Butyl carbamate (7 mmol) was added to the reaction mixture, and the contents were heated at 80° C. for 2 h. The reaction mixture was cooled to room temperature and filtered through Celite. The solvent was removed in vacuo and the residue obtained was purified by flash column chromatography using DCM as eluant to yield (2-cyclohexylphenyl)-carbamic acid tert-butyl ester. The reaction mixture was cooled to room temperature filtered through Celite The solvent was removed in vacuo the residue obtained was purified by flash column chromatography
ソース ID: ord-5c9aa02c09ef4d0abbfa50e646441744PubChem References
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