methyl 2-[3-(ethylamino)phenyl]acetate

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: To the solution of methyl 2-(3-aminophenyl)acetate (150 mg, 0.83 mmol) and acetaldehyde (80.5 mg, 1.83 mmol) in methanol (6 mL) was added NaBH3CN (130.3 mg, 2.08 mmol) and AcOH (1 drop, cat.). The mixture was stirred at room temperature for 12 h. Then, the reaction was quenched with aqueous ammonium chloride and extracted with DCM. The organic layer was with brine, dried over sodium sulfate and evaporated under reduced pressure. The residue was purified by a standard method to get methyl 2-(3-(diethylamino)phenyl)acetate and methyl 2-(3-(ethylamino)phenyl)acetate. Then, the reaction was quenched with aqueous ammonium chloride extracted with DCM dried over sodium sulfate evaporated under reduced pressure The residue was purified by a standard method

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: To the solution of methyl 2-(3-aminophenyl)acetate (150 mg, 0.83 mmol) and acetaldehyde (80.5 mg, 1.83 mmol) in methanol (6 mL) was added NaBH3CN (130.3 mg, 2.08 mmol) and AcOH (1 drop, cat.). The mixture was stirred at room temperature for 12 h. Then, the reaction was quenched with aqueous ammonium chloride and extracted with DCM. The organic layer was with brine, dried over sodium sulfate and evaporated under reduced pressure. The residue was purified by a standard method to get methyl 2-(3-(diethylamino)phenyl)acetate and methyl 2-(3-(ethylamino)phenyl)acetate. Then, the reaction was quenched with aqueous ammonium chloride extracted with DCM dried over sodium sulfate evaporated under reduced pressure The residue was purified by a standard method