ethyl 3-(2-chloroanilino)-2-methyl-3-oxopropanoate

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: The acid was prepared according to Procedure B using ethyl 3-(2-chlorophenylamino)-2-methyl-3-oxopropanoate (1.8 g, 7.04 mmol) in THF (7.0 mL) to give 3-(2-chlorophenylamino)-2-methyl-3-oxopropanoic acid. Mass Spectrum (ESI) m/e=228.1 (M+1). The acid was prepared

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: The ester was prepared according to Procedure A using diethyl 2-methylmalonate (6.1 mL, 35.3 mmol), pyridine (3.80 mL, 47.0 mmol) and 2-chloroaniline (3.00 g, 23.52 mmol). The reaction mixture was heated for 6 days. The residue was purified by column chromatography on silica gel (0-30% EtOAc/hexanes) to give ethyl 3-(2-chlorophenylamino)-2-methyl-3-oxopropanoate. Mass Spectrum (ESI) m/e=256.1 (M+1). The ester was prepared The reaction mixture was heated for 6 days The residue was purified by column chromatography on silica gel (0-30% EtOAc/hexanes)